2.5.1.106: tryprostatin B synthase
This is an abbreviated version!
For detailed information about tryprostatin B synthase, go to the full flat file.
Word Map on EC 2.5.1.106
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2.5.1.106
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prenylation
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aspergillus
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fumigatus
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dipeptides
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tryptophan-containing
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dimethylallyltryptophan
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cyclo-l-trp-l-pro
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tryprostatins
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regiospecific
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dmapp
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regioselectivity
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fumitremorgins
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7-dmats
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chemoenzymatic
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anapt
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diketopiperazine
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cdpnpt
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barrel
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actinomycetes
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isoprenoid
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coelicolor
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l-tryptophan
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fischeri
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neosartorya
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ergot
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fgapt2
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l-trp
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medicine
- 2.5.1.106
-
prenylation
- aspergillus
- fumigatus
- dipeptides
-
tryptophan-containing
- dimethylallyltryptophan
- cyclo-l-trp-l-pro
-
tryprostatins
-
regiospecific
-
dmapp
-
regioselectivity
-
fumitremorgins
- 7-dmats
-
chemoenzymatic
- anapt
-
diketopiperazine
- cdpnpt
-
barrel
- actinomycetes
-
isoprenoid
- coelicolor
- l-tryptophan
- fischeri
-
neosartorya
-
ergot
- fgapt2
- l-trp
- medicine
Reaction
Synonyms
brevianamide F prenyltransferase, cyclic dipeptide C2-prenyltransferase FtmPT1, FtmPT1, indole prenyltransferase, tryprostatin B synthase
ECTree
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Engineering
Engineering on EC 2.5.1.106 - tryprostatin B synthase
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E102Q
mutation reduces the production of tryprostatin B to undetectable amounts
G115A
G115A/Y205C
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
G115L
formation of tryprostatin B is abolished, formation of a new product occurs
G115T
Y205C
Y205D
mutant produces 55.8% C3-regularly prenylated product and 3.6% C3-reversely prenylated product
Y205E
mutant produces 57.6% C3-regularly prenylated product and 3% C3-reversely prenylated product
Y205F
Y205G
mutant produces 92% C3-regularly prenylated product and 12.2% C3-reversely prenylated product
Y205I
Y205K
mutant produces 110% C3-regularly prenylated product and 1.6% C3-reversely prenylated product
Y205L
Y205M
Y205N
mutant produces 70% C3-regularly prenylated product and 2.8% C3-reversely prenylated product
Y205R
mutant produces 77% C3-regularly prenylated product and 13.2% C3-reversely prenylated product
Y205S
E102Q
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mutation reduces the production of tryprostatin B to undetectable amounts
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G115L
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formation of tryprostatin B is abolished, formation of a new product occurs
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G115T
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0.4% of wild-type activity in formation of trytrostatin B. Mutant catalyzes the formation of a different product that carries a reverse prenyl moiety at the C-3 of the indole nucleus
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G115A
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
0.4% of wild-type activity in formation of trytrostatin B. Mutant catalyzes the formation of a different product that carries a reverse prenyl moiety at the C-3 of the indole nucleus
G115T
the mutant produces a five-membered ring compound as the major product with tryprostatin B as the minor product
Y205C
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
Y205F
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
Y205I
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
Y205L
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
Y205M
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme
mutant produces 50.4% C3-regularly prenylated product and 1.8% C3-reversely prenylated product
Y205S
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significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme