2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase
This is an abbreviated version!
For detailed information about 2-(3-amino-3-carboxypropyl)histidine synthase, go to the full flat file.
Word Map on EC 2.5.1.108
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2.5.1.108
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diphtheria
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toxin
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horikoshii
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pyrococcus
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s-adenosylmethionine
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cluster-containing
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fe-s
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heterodimer
- 2.5.1.108
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diphtheria
- toxin
- horikoshii
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pyrococcus
- s-adenosylmethionine
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cluster-containing
- fe-s
- heterodimer
Reaction
Synonyms
diphthamide biosynthesis protein 2, diphthine synthase, Dph1-Dph2, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase
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Reaction
Reaction on EC 2.5.1.108 - 2-(3-amino-3-carboxypropyl)histidine synthase
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S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
The relevant histidine of translation elongation factor 2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
unlike the enzymes in the radical S-adenosyl-L-methionine superfamily, Dph2 does not form the canonical 5'-deoxyadenosyl radical. Instead, it breaks the Cgamma,Met-S bond of S-adenosyl-L-methionine and generates a 3-amino-3-carboxylpropyl radical