2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase

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For detailed information about 2-(3-amino-3-carboxypropyl)histidine synthase, go to the full flat file.

Reaction

Synonyms

diphthamide biosynthesis protein 2, diphthine synthase, Dph1-Dph2, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.108 2-(3-amino-3-carboxypropyl)histidine synthase

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Results	in table
9173	AA Sequence
9	Cloned(Commentary)
7	Cofactor
4	Crystallization (Commentary)
8	General Information
1	Localization
4	Metals/Ions
3	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
85	Organism
2	Pathway
8	PDB ID
1	pH Optimum
12	Protein Variants
6	Purification (Commentary)
3	Reaction
16	Reference
1	Source Tissue
23	Substrates and Products (Substrate)
14	Subunits
21	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.5.1.108 - 2-(3-amino-3-carboxypropyl)histidine synthase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:L-histidine-[translation elongation factor 2] 2-[(3S)-3-amino-3-carboxypropyl]transferase

A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.