2.5.1.116: homogentisate geranylgeranyltransferase
This is an abbreviated version!
For detailed information about homogentisate geranylgeranyltransferase, go to the full flat file.
Reaction
Synonyms
HGGT, homogentisic acid geranylgeranyl transferase, Hppt, slr1736
ECTree
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General Information
General Information on EC 2.5.1.116 - homogentisate geranylgeranyltransferase
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physiological function
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the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols
physiological function
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combined expression of hydroxyphenylpyruvate dioxygenase/bi-functional chorismate mutase/prephenate dehydrogenase and homogentisate geranylgeranyl transferase in Arabidopsis leaves and seeds results in large additive increases in vitamin E production, indicating that homogentisate concentrations limit homogentisate geranylgeranyl transferase-catalyzed tocotrienol synthesis
physiological function
SLR1736 gene disruption does not lead to significant differences in cellular plastoquinone, phylloquinone, and chlorophyll levels, but causes absence of tocopherols without affecting plastoquinone-9 levels
physiological function
transgenic expression of the barley homogentisic acid geranylgeranyl transferase in Arabidopsis thaliana leaves results in accumulation of tocotrienols, which are absent from leaves of nontransformed plants, and a 10- to 15fold increase in total tocotrienols plus tocopherols. Overexpression of the barley enzyme in corn seeds results in an increase in tocotrienol and tocopherol content of as much as 6fold
physiological function
tocotrienol precursors such as homogentisate and geranylgeranyl diphosphate decrease during maturation of the grain. HGGT is an essential, but not limiting factor for tocotrienol biosynthesis, and tocotrienol precursors can regulate the tocotrienol level in grain
physiological function
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the enzyme is involved in the biosynthesis of the vitamin E, tocotrienols
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