2.5.1.125: 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase

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For detailed information about 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase, go to the full flat file.

Reaction

Synonyms

Fur7

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.125 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
4	General Information
4	kcat/KM [mM/s]
8	KM Value [mM]
2	Metals/Ions
1	Natural Substrates/ Products (Substrates)
3	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reference
6	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.5.1.125 - 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

dimethylallyl diphosphate + flaviolin

?

Streptomyces sp.

-

-

725410

-

-

?

geranyl diphosphate + 1,3-dihydroxynaphthalene

?

Streptomyces sp.

-

-

725410

-

-

?

geranyl diphosphate + 2-O-methyl-3-methylflaviolin

diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione

2 entries

geranyl diphosphate + flaviolin

diphosphate + 3-(3,7-dimethylocta-1,6-dien-3-yl)-2,5,7-trihydroxynaphthalene-1,4-dione

Streptomyces sp.

-

-

725410

-

-

?

geranyl diphosphate + flaviolin

diphosphate + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,5,7-trihydroxynaphthalene-1,4-dione

Streptomyces sp.

-

i.e. 2,5,7-trihydroxynaphthalene-1,4-dione. The kcat/Km of the prenylation of flaviolin is significantly higher than that of the prenylation of the natural substrate 2-O-methyl-3-methylflaviolin

725410

-

-

?

geranyl diphosphate + 2-O-methyl-3-methylflaviolin

diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione

Streptomyces sp.

-

the enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin. It catalyses the transfer of a geranyl group to 2-O-methyl-3-methyl-flaviolin to yield 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione and 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione in a 1:10 ratio

725410

-

-

?

geranyl diphosphate + 2-O-methyl-3-methylflaviolin

diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione

Streptomyces sp.

-

the enzyme catalyses the transfer of a geranyl group to 2-O-methyl-3-methyl-flaviolin to yield 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione and 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione in a 1:10 ratio

725410

-

-

?