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2.5.1.126: norspermine synthase

This is an abbreviated version!
For detailed information about norspermine synthase, go to the full flat file.

Reaction

S-adenosyl 3-(methylsulfanyl)propylamine
+
norspermidine
=
S-methyl-5'-thioadenosine
 +
norspermine

Synonyms

long-chain polyamine synthase, PaSpeE

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.126 norspermine synthase

Natural Substrates Products

Natural Substrates Products on EC 2.5.1.126 - norspermine synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldoheptamine
show the reaction diagram
S-adenosyl 3-(methylthio)propylamine + caldopentamine
S-methyl-5'-thioadenosine + caldohexamine
show the reaction diagram
S-adenosyl 3-(methylthio)propylamine + norspermidine
S-methyl-5'-thioadenosine + norspermine
show the reaction diagram
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + norspermine
S-methyl-5'-thioadenosine + caldopentamine
show the reaction diagram
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine
S-methyl-5'-thioadenosine + norspermidine
show the reaction diagram
the long-chain polyamines stabilize double-stranded DNA at high temperatures
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + thermospermine + H+
show the reaction diagram
spermidine is not the most preferred substrate for any enzyme. Nevertheless, in vivo the enzyme can be responsible for the synthesis of thermospermine, if spermidine is present in a high concentration in competition to other accepted polyamines
-
-
?