2.5.1.128: N4-bis(aminopropyl)spermidine synthase

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For detailed information about N4-bis(aminopropyl)spermidine synthase, go to the full flat file.

Reaction

2 S-adenosyl 3-(methylsulfanyl)propylamine +

Synonyms

BpsA, TK1691

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.128 N4-bis(aminopropyl)spermidine synthase

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Results	in table
420	AA Sequence
1	Cloned(Commentary)
2	General Information
1	Natural Substrates/ Products (Substrates)
1	Organism
2	Pathway
21	PDB ID
1	pH Optimum
1	Purification (Commentary)
6	Reaction
1	Reference
2	Specific Activity [micromol/min/mg]
5	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.5.1.128 - N4-bis(aminopropyl)spermidine synthase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase (N4-bis(aminopropyl)spermidine synthesizing)

The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N4-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N4-aminopropylspermine.