2.5.1.15: dihydropteroate synthase

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For detailed information about dihydropteroate synthase, go to the full flat file.

Reaction

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.15 dihydropteroate synthase

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Results	in table
4	Activating Compound
36488	AA Sequence
12	Application
1	CAS Registry Number
32	Cloned(Commentary)
2	Cofactor
18	Crystallization (Commentary)
25	General Information
18	IC50 Value
282	Inhibitors
16	kcat/KM [mM/s]
138	Ki Value [mM]
65	KM Value [mM]
5	Localization
11	Metals/Ions
24	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
114	Organism
6	Pathway
162	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
93	Protein Variants
30	Purification (Commentary)
4	Reaction
7	Reaction Type
99	Reference
11	Source Tissue
25	Specific Activity [micromol/min/mg]
8	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
144	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
35	Turnover Number [1/s]

pH Range

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pH Range on EC 2.5.1.15 - dihydropteroate synthase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

7 - 10.5

Escherichia coli

-

70% of maximal activity at pH 7.0 and 10.5

639666

7 - 9.3

Saccharomyces cerevisiae

P53848

pH 7.0: about 50% of maximal activity, pH 9.3: about 60% of maximal activity, dihydropteroate synthase activity of the recombinant bifunctional fusion protein encoding dihydropterin pyrophosphokinase and dihyropteroate synthase domains of the trifunctional enzyme dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase

663313

8.5 - 10.5

Plasmodium falciparum

-

pH 8.5: about 40% of maximal activity, pH 10.5: about 85% of maximal activity

662800