2.5.1.16: spermidine synthase

This is an abbreviated version!
For detailed information about spermidine synthase, go to the full flat file.

Reaction

Synonyms

aminopropyltransferase, aminopropyltransferase spermidine synthase, AtSPDS1, AtSPDS2, MdSPDS1, PAPT, PgSPD, putrescine aminopropyltransferase, Spd synthase, SPDS, SPDS2, SPDSYN, spe-sdh, spe3, SpeE, spermidine synthase, spermidine synthase 1, spermidine synthetase, Spm synthase, SpSyn, Synpcc7942_0628, synthase, spermidine

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.16 spermidine synthase

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Results	in table
2	Activating Compound
21026	AA Sequence
5	Application
1	CAS Registry Number
40	Cloned(Commentary)
4	Cofactor
14	Crystallization (Commentary)
93	Disease/ Diagnostics
2	Expression
30	General Information
14	General Stability
10	IC50 Value
198	Inhibitors
6	kcat/KM [mM/s]
10	Ki Value [mM]
51	KM Value [mM]
6	Localization
13	Metals/Ions
53	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
650	Organism
7	Pathway
196	PDB ID
27	pH Optimum
5	pH Range
4	pH Stability
2	pI Value
24	Protein Variants
42	Purification (Commentary)
15	Reaction
1	Reaction Type
125	Reference
118	Source Tissue
18	Specific Activity [micromol/min/mg]
18	Storage Stability
206	Substrates and Products (Substrate)
41	Subunits
80	Synonyms
1	Systematic Name
37	Temperature Optimum [°C]
4	Temperature Range [°C]
8	Temperature Stability [°C]
22	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.5.1.16 - spermidine synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000051

2-phenyl-1,2-thiazol-3(2H)-one

Trypanosoma cruzi

Q4DA73

pH and temperature not specified in the publication

737352

0.18

2H-1,4-benzothiazin-3-amine

Trypanosoma cruzi

Q4DA73

pH and temperature not specified in the publication

737352

0.0091

5-[(4-methylbenzyl)oxy]quinazolin-2-amine

Trypanosoma cruzi

Q4DA73

pH and temperature not specified in the publication

737352

0.0024

Cyclohexylamine

Caenorhabditis elegans

-

IC50 2.4 +/- 0.7 microM

661768

0.46

isoquinolin-1-amine

Trypanosoma cruzi

Q4DA73

pH and temperature not specified in the publication

737352

0.53

N-methyl-N-phenyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide

Trypanosoma cruzi

Q4DA73

pH and temperature not specified in the publication

737352

0.83

quinolin-8-yl piperidine-1-carboxylate

Trypanosoma cruzi

Q4DA73

pH and temperature not specified in the publication

737352

0.0002

S-Adenosyl-1,8-diamino-3-thiooctane

Thermotoga maritima

-

IC50 of 0.0002 mM

639718

0.0014 - 0.0072

trans-4-Methylcyclohexylamine

2 entries

0.0014

trans-4-Methylcyclohexylamine

Plasmodium falciparum

Q9NFS5

IC50 1.4 microM

662805

0.0072

trans-4-Methylcyclohexylamine

Caenorhabditis elegans

-

IC50 7.2 microM

661768