2.5.1.2: thiamine pyridinylase

This is an abbreviated version!
For detailed information about thiamine pyridinylase, go to the full flat file.

Word Map on EC 2.5.1.2

2.5.1.2

thiaminolyticus

medicine

thiazole

aniline

pseudoharengus

viscera

bivalve

alosa

analysis

nutrition

Reaction

1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium

Synonyms

pyrimidine transferase, thiamin hydrolase, thiamin pyridinolase, thiamin pyridinylase, thiaminase, thiaminase I, thiamine pyridinolase, thiamine pyridinylase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.2 thiamine pyridinylase

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Results	in table
50	Activating Compound
111	AA Sequence
13	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
21	General Information
62	Inhibitors
8	kcat/KM [mM/s]
2	Ki Value [mM]
62	KM Value [mM]
12	Localization
2	Metals/Ions
9	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
121	Organism
1	Oxidation Stability
2	Pathway
24	PDB ID
19	pH Optimum
5	pH Range
9	pH Stability
1	pI Value
7	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
117	Reference
130	Source Tissue
4	Specific Activity [micromol/min/mg]
105	Substrates and Products (Substrate)
3	Subunits
28	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
17	Temperature Range [°C]
10	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.5.1.2 - thiamine pyridinylase

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2-mercaptoethanol

3 entries

4,5-dimethylthiazole

Paenibacillus thiaminolyticus

reactivation at 10 mM

636849

5-(2-chloroethyl)-4-methylthiazole

Paenibacillus thiaminolyticus

reactivation at 10 mM

636849

5-(2-hydroxyethyl)-4-methylthiazole

Paenibacillus thiaminolyticus

reactivation at 10 mM

aniline

aromatic amines

cysteine

complete reactivation at 3.3 mM but inhibition at 33 mM

636851

dithiothreitol

2 entries

heterocyclic amines

10 entries

Pyridine

Paenibacillus thiaminolyticus

at 25 mM restores activity inhibited by heteropyrimidine at 0.006 mM

636849

sulfhydryl compounds

3 entries

Thioglycollate

Marsilea drummondii

greater reactivation at 33 mM than at 3.3 mM

636851

thiosulphate

Marsilea drummondii

greater reactivation at 33 mM than at 3.3 mM

636851

additional information

8 entries