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2.5.1.2: thiamine pyridinylase

This is an abbreviated version!
For detailed information about thiamine pyridinylase, go to the full flat file.

Word Map on EC 2.5.1.2

Reaction

thiamine
+
Pyridine
=
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium
 +
4-methyl-5-(2-hydroxyethyl)thiazole

Synonyms

pyrimidine transferase, thiamin hydrolase, thiamin pyridinolase, thiamin pyridinylase, thiaminase, thiaminase I, thiamine pyridinolase, thiamine pyridinylase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.2 thiamine pyridinylase

Substrates Products

Substrates Products on EC 2.5.1.2 - thiamine pyridinylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1'-methylthiamine + aniline
4-methyl-5-(2-hydroxyethyl)-thiazole + 4-amino-5-(anilinomethyl)-1,2-dimethylpyrimidin-1-ium
show the reaction diagram
-
22% of activity with thiamine
-
-
?
2'-ethylthiamine + aniline
4-methyl-5-(2-hydroxyethyl)-thiazole + 5-(anilinomethyl)-2-ethylpyrimidin-4-amine
show the reaction diagram
-
63% of activity with thiamine
-
-
?
2-(1-hydroxyethyl)thiamine + aniline
4-methyl-2-(1-hydroxyethyl)-5-(2-hydroxyethyl)-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
92% of activity with thiamine
-
-
?
5-chloroethylthiamine + aniline
4-methyl-5-chloroethyl-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
67% of activity with thiamine
-
-
?
5-nor-thiamine + aniline
4-methyl-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
88% of activity with thiamine
-
-
?
O-(beta-D-galactosyl)thiamine + aniline
4-methyl-5-(2-hydroxyethyl-O-beta-D-galactosyl)-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
63% of activity with thiamine
-
-
?
O-benzoylthiamine + aniline
2-(4-methyl-1,3-thiazol-5-yl)ethyl benzoate + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
91% of activity with thiamine
-
-
?
O-S-diacetylthiamine + aniline
1-acetyl-4-methyl-5-(2-hydroxyethyl-O-acetyl)-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
50% of activity with thiamine
-
-
?
O-succinylthiamine + aniline
4-methyl-5-(2-hydroxyethyl-O-succinyl)-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
83% of activity with thiamine
-
-
?
pyrithiamine + aniline
2-(2-methylpyridin-3-yl)ethanol + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
72% of activity with thiamine
-
-
?
tetrahydrothiamine + aniline
?
show the reaction diagram
-
84% of activity with thiamine
-
-
?
thiamine
?
show the reaction diagram
thiamine + 2-aminopyridine
?
show the reaction diagram
-
-
-
-
?
thiamine + 2-hydroxyaniline
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(2-hydroxyphenyl)amine
show the reaction diagram
-
-
-
-
?
thiamine + 2-mercaptobenzoic acid
?
show the reaction diagram
-
-
-
-
?
thiamine + 2-mercaptoethanol
?
show the reaction diagram
thiamine + 2-methylbenzeneamine
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(2-methylphenyl)amine
show the reaction diagram
-
i.e. o-toluidine
-
-
?
thiamine + 2-pyridinecarboxylic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxypyridinium
show the reaction diagram
-
i.e. alpha-picolinic acid
-
-
?
thiamine + 3-aminopyridine
?
show the reaction diagram
thiamine + 3-hydroxyaniline
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(3-hydroxyphenyl)amine
show the reaction diagram
-
-
-
-
?
thiamine + 3-methylbenzeneamine
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(3-methylphenyl)amine
show the reaction diagram
-
i.e. m-toluidine
-
-
?
thiamine + 3-nitroaniline
?
show the reaction diagram
-
-
-
-
?
thiamine + 3-pyridinecarboxylic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-carboxypyridinium
show the reaction diagram
-
i.e. beta-picolinic acid
-
-
?
thiamine + 4-aminopyridine
?
show the reaction diagram
thiamine + 4-hydroxyaniline
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(4-hydroxyphenyl)amine
show the reaction diagram
-
-
-
-
?
thiamine + 4-methylbenzeneamine
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(4-methylphenyl)amine
show the reaction diagram
-
i.e. p-toluidine
-
-
?
thiamine + 4-nitrothiophenolate
4-methyl-5-(2-hydroxyethyl)thiazole + 2-methyl-5[[(4-nitrophenyl)sulfanyl]methyl]pyrimidin-4-amine
show the reaction diagram
no activity with thiaminase II
-
-
?
thiamine + 4-nitrothiophenolate
?
show the reaction diagram
-
-
-
?
thiamine + 4-pyridinecarboxylic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-carboxypyridinium
show the reaction diagram
-
i.e. gamma-picolinic acid
-
-
?
thiamine + 6-aminohexanoic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 6-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]hexanoic acid
show the reaction diagram
-
-
-
-
?
thiamine + adenine
?
show the reaction diagram
-
-
-
-
?
thiamine + alpha-picoline
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]alpha-picolinium
show the reaction diagram
-
-
-
-
?
thiamine + aniline
5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
show the reaction diagram
thiamine + beta-picoline
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]beta-picolinium
show the reaction diagram
-
-
-
-
?
thiamine + cysteine
?
show the reaction diagram
-
-
-
-
?
thiamine + gamma-picoline
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]gamma-picolinium
show the reaction diagram
-
-
-
-
?
thiamine + hydroxyproline
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]4-hydroxypyrrolidine-2-carboxylic acid
show the reaction diagram
thiamine + imidazole
4-methyl-5-(2-hydroxyethyl)-thiazole + 5-(1H-imidazol-1-yl-methyl)-2-methylpyrimidin-4-amine
show the reaction diagram
thiamine + L-cysteine
4-methyl-5-(2-hydroxyethyl)-thiazole + 2-[[(4-amino-2-ethylpyrimidin-5-yl)methyl]amino]-3-mercaptopropanoic acid
show the reaction diagram
thiamine + L-lysine
?
show the reaction diagram
-
-
-
-
?
thiamine + m-aminobenzoic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 3-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
show the reaction diagram
-
-
-
-
?
thiamine + m-phenylene diamine
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(3-aminophenyl)amine
show the reaction diagram
-
-
-
-
?
thiamine + methylamine
?
show the reaction diagram
-
-
-
-
?
thiamine + nicotinic acid
?
show the reaction diagram
thiamine + o-aminobenzoic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 2-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
show the reaction diagram
-
-
-
-
?
thiamine + o-phenylene diamine
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(2-aminophenyl)amine
show the reaction diagram
-
-
-
-
?
thiamine + p-aminobenzoic acid
4-methyl-5-(2-hydroxyethyl)-thiazole + 4-[[(4-amino-2-methylpyrimidin-5-yl)methyl]amino]benzoic acid
show the reaction diagram
-
-
-
-
?
thiamine + p-phenylene diamine
4-methyl-5-(2-hydroxyethyl)-thiazole + [(4-amino-2-methylpyrimidin-5-yl)methyl]-N-(4-aminophenyl)amine
show the reaction diagram
-
-
-
-
?
thiamine + proline
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyrrolidine-2-carboxylic acid
show the reaction diagram
thiamine + pyridine
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole
show the reaction diagram
thiamine + pyridine
heteropyrithiamine + 4-methyl-5-(2-hydroxyethyl)-thiazole
show the reaction diagram
thiamine + pyridoxine
?
show the reaction diagram
-
-
-
-
?
thiamine + quinoline
4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]quinolinium
show the reaction diagram
thiamine + sulfanilamide
?
show the reaction diagram
-
-
-
-
?
thiamine + sulfanilic acid
?
show the reaction diagram
-
-
-
-
?
thiamine + Tris
?
show the reaction diagram
-
-
-
-
?
thiamine + veratrylamine
bis-(4-amino-2-methyl)pyrimidinyl-3,4-dimethoxybenzylamine + 4-methyl-5-(2-hydroxyethyl)-thiazole
show the reaction diagram
the reaction can occur without base substrate
-
?
thiamine disulfide + aniline
?
show the reaction diagram
-
26% of activity with thiamine
-
-
?
thiamine phosphate + aniline
2-(4-methyl-1,3-thiazol-5-yl)ethyl dihydrogenphosphate + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
64% of activity with thiamine
-
-
?
thiothiamine + aniline
4-methyl-5-(2-hydroxyethyl)-2-thio-thiazole + 5-(anilinomethyl)-2-methylpyrimidin-4-amine
show the reaction diagram
-
12% of activity with thiamine
-
-
?
additional information
?
-