2.5.1.2: thiamine pyridinylase

This is an abbreviated version!
For detailed information about thiamine pyridinylase, go to the full flat file.

Reaction

Synonyms

pyrimidine transferase, thiamin hydrolase, thiamin pyridinolase, thiamin pyridinylase, thiaminase, thiaminase I, thiamine pyridinolase, thiamine pyridinylase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.2 thiamine pyridinylase

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Results	in table
50	Activating Compound
111	AA Sequence
13	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
21	General Information
62	Inhibitors
8	kcat/KM [mM/s]
2	Ki Value [mM]
62	KM Value [mM]
12	Localization
2	Metals/Ions
9	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
121	Organism
1	Oxidation Stability
2	Pathway
24	PDB ID
19	pH Optimum
5	pH Range
9	pH Stability
1	pI Value
7	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
117	Reference
130	Source Tissue
4	Specific Activity [micromol/min/mg]
105	Substrates and Products (Substrate)
3	Subunits
28	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
17	Temperature Range [°C]
10	Turnover Number [1/s]

pI Value

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pI Value on EC 2.5.1.2 - thiamine pyridinylase

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pI VALUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.7

Fistularia petimba

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the liver of Fisturalia petimba contains thiaminase I of at least three different pIs and the major fraction exhibits pI 5.7. The most evident difference among pI isozymes is the size of the active subfragments into which they are dissociated. pI 5.7 enzyme dissociates into subfragments of 25 kDa, while pI 7-9 enzymes dissociates into approximately 22000 Da. The reaction rate measured by pyridine as the second substrate is three times higher in pI 7-9 enzymes compared with pI 5.7 enzyme. The degree of cadmium inhibition, when aniline is the cosubstrate, shows obvious differences between pI isozymes

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