2.5.1.21: squalene synthase

This is an abbreviated version!
For detailed information about squalene synthase, go to the full flat file.

Word Map on EC 2.5.1.21

2.5.1.21

farnesylation

cholesterol

prenylation

sterol

ftase

mevalonate

geranylgeranylation

isoprenoids

leukemia

geranylgeranyltransferase

pyrophosphate

tipifarnib

hmg-coa

statin

h-ras

peptidomimetic

epoxidase

prenyltransferase

dolichols

rhob

isoprenylation

triterpene

farnesol

3-hydroxy-3-methylglutaryl

lamins

ergosterol

cholesterol-lowering

hmgcr

prelamin

p21ras

lovastatin

hutchinson-gilford

lanosterol

manumycin

triterpenoids

synthesis

progerin

farnesylpyrophosphate

cis-prenyltransferase

drug development

oxidosqualene

ras-transformed

medicine

ras-dependent

nonsterols

ras-mediated

withanolides

srebp-2

ganoderic

agriculture

geranylgeraniol

industry

cycloartenol

non-thiol

2,3-oxidosqualene

Reaction

2 (2E,6E)-farnesyl diphosphate +

+ 2 diphosphate +

Synonyms

BbSS, BSS, CrSQS, dt-ySQase, Erg9, EtSS, farnesyl-diphosphate farnesyltransferase, farnesyl-diphosphate:farnesyldiphosphate farnesyltransferase, farnesyldiphosphate farnesyltransferase 1, farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, farnesyltransferase, FDFT1, hSQS, presqualene synthase, presqualene-diphosphate synthase, SgSQS, SQase, SQS, SQS1, SQS2, squalene synthase, squalene synthase 1, squalene synthase 2, squalene synthetase, SS1, SSase, SSN, synthase, squalene, TkSQS1, TkSQS2

Results	in table
14	Activating Compound
5668	AA Sequence
19	Application
1	CAS Registry Number
61	Cloned(Commentary)
63	Cofactor
4	Crystallization (Commentary)
2119	Disease/ Diagnostics
6	Expression
85	General Information
12	General Stability
108	IC50 Value
227	Inhibitors
4	kcat/KM [mM/s]
2	Ki Value [mM]
29	KM Value [mM]
66	Localization
50	Metals/Ions
33	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
128	Organism
6	Pathway
136	PDB ID
14	pH Optimum
4	pH Range
1	pH Stability
9	pI Value
66	Protein Variants
28	Purification (Commentary)
14	Reaction
11	Reaction Type
127	Reference
84	Source Tissue
13	Specific Activity [micromol/min/mg]
3	Storage Stability
155	Substrates and Products (Substrate)
35	Subunits
98	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
3	Temperature Stability [°C]
8	Turnover Number [1/s]

2.5.1.21: squalene synthase

Reaction

Synonyms

ECTree

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Molecular Weight

Molecular Weight on EC 2.5.1.21 - squalene synthase