2.5.1.21: squalene synthase
This is an abbreviated version!
For detailed information about squalene synthase, go to the full flat file.
Word Map on EC 2.5.1.21
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2.5.1.21
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farnesylation
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cholesterol
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prenylation
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sterol
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ftase
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mevalonate
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geranylgeranylation
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isoprenoids
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leukemia
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geranylgeranyltransferase
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pyrophosphate
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tipifarnib
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hmg-coa
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statin
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h-ras
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peptidomimetic
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epoxidase
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prenyltransferase
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dolichols
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rhob
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isoprenylation
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triterpene
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farnesol
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3-hydroxy-3-methylglutaryl
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lamins
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ergosterol
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cholesterol-lowering
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hmgcr
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prelamin
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p21ras
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lovastatin
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hutchinson-gilford
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lanosterol
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manumycin
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triterpenoids
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synthesis
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progerin
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farnesylpyrophosphate
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cis-prenyltransferase
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drug development
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oxidosqualene
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ras-transformed
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medicine
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ras-dependent
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nonsterols
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ras-mediated
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withanolides
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srebp-2
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ganoderic
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agriculture
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geranylgeraniol
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industry
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cycloartenol
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non-thiol
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2,3-oxidosqualene
- 2.5.1.21
-
farnesylation
- cholesterol
-
prenylation
- sterol
- ftase
- mevalonate
-
geranylgeranylation
-
isoprenoids
- leukemia
-
geranylgeranyltransferase
- pyrophosphate
- tipifarnib
- hmg-coa
- statin
- h-ras
-
peptidomimetic
-
epoxidase
- prenyltransferase
- dolichols
- rhob
-
isoprenylation
-
triterpene
- farnesol
-
3-hydroxy-3-methylglutaryl
- lamins
- ergosterol
-
cholesterol-lowering
- hmgcr
-
prelamin
-
p21ras
- lovastatin
-
hutchinson-gilford
- lanosterol
- manumycin
-
triterpenoids
- synthesis
-
progerin
-
farnesylpyrophosphate
- cis-prenyltransferase
- drug development
- oxidosqualene
-
ras-transformed
- medicine
-
ras-dependent
-
nonsterols
-
ras-mediated
-
withanolides
- srebp-2
-
ganoderic
- agriculture
- geranylgeraniol
- industry
- cycloartenol
-
non-thiol
- 2,3-oxidosqualene
Reaction
2 (2E,6E)-farnesyl diphosphate + + = + 2 diphosphate +
Synonyms
BbSS, BSS, CrSQS, dt-ySQase, Erg9, EtSS, farnesyl-diphosphate farnesyltransferase, farnesyl-diphosphate:farnesyldiphosphate farnesyltransferase, farnesyldiphosphate farnesyltransferase 1, farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, farnesyltransferase, FDFT1, hSQS, presqualene synthase, presqualene-diphosphate synthase, SgSQS, SQase, SQS, SQS1, SQS2, squalene synthase, squalene synthase 1, squalene synthase 2, squalene synthetase, SS1, SSase, SSN, synthase, squalene, TkSQS1, TkSQS2
ECTree
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Organism
Organism on EC 2.5.1.21 - squalene synthase
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collected in autumn 2014, from Qianshan County in Anhui Province, China, gene MoSQS
UniProt
Thermosynechococcus vestitus
isoform Sqs1. Sqs1 is the only functional squalene synthase in Arabidopsis thaliana. Isoform Sqs2 has no squalene synthase activity
UniProt
isoform Sqs2, lacking enzymatic activity due to the presence of an unusual Ser replacing the highly conserved Phe at position 287
O23118
UniProt
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overexpression in Eleutherococcus senticosus, results in enzyme activity up to 3fold higher than wild-type and increase in phytosterols beta-sitosterol and stigmasterol as well as in triterpene saponin levels
Uniprot
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