2.5.1.22: spermine synthase
This is an abbreviated version!
For detailed information about spermine synthase, go to the full flat file.
Word Map on EC 2.5.1.22
-
2.5.1.22
-
polyamine
-
putrescine
-
s-adenosylmethionine
-
ornithine
-
aminopropyltransferases
-
snyder-robinson
-
alpha-difluoromethylornithine
-
acaulis5
-
thermospermine
-
trans-4-methylcyclohexylamine
-
gyro
-
kyphoscoliosis
-
agriculture
-
adometdc
-
2.5.1.16
-
medicine
- 2.5.1.22
- polyamine
- putrescine
- s-adenosylmethionine
- ornithine
- aminopropyltransferases
-
snyder-robinson
- alpha-difluoromethylornithine
- acaulis5
- thermospermine
- trans-4-methylcyclohexylamine
-
gyro
-
kyphoscoliosis
- agriculture
- adometdc
-
2.5.1.16
- medicine
Reaction
Synonyms
ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 2.5.1.22 - spermine synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
1-aminooxy-3-N-[3-aminopropyl]-aminopropane
-
aminooxy analogue of spermidine, kinetics
5-[5'-deoxy-5'-(C)-4',5'-didehydroadenosyl]-L-ornithine
-
i.e. compound A9154C, prostate
5'-methylthioadenosine
SpmSyn is strongly inhibited by 5'-methylthioadenosine. This inhibition does not have great importance in limiting spermine synthesis in vivo because 5'-methylthioadenosine is normally rapidly degraded by 5'-methylthioadenosine phosphorylase. Inhibition of this enzyme allows 5'-methylthioadenosine to accumulate with deleterious effects on polyamine content.
-
no inhibition by erythro-9-(2-hydroxy-3-nonyl)adenine, methylglyoxal-bis-(guanylhydrazone), aminoguanidine, guanethidine, L-canaline, MgCl2, KCl, diamines, polyamines, polyamine derivatives
-
additional information
the spermine synthase-5'-methylthioadenosine structure provides a plausible explanation for the potent inhibition of the reaction by this product and the stronger inhibition of spermine synthase compared with spermidine synthase.
-
additional information
-
not inhibitory: cyclohexylamine or dicyclohexylamine; overview on inhibitors
-