2.5.1.22: spermine synthase
This is an abbreviated version!
For detailed information about spermine synthase, go to the full flat file.
Word Map on EC 2.5.1.22
-
2.5.1.22
-
polyamine
-
putrescine
-
s-adenosylmethionine
-
ornithine
-
aminopropyltransferases
-
snyder-robinson
-
alpha-difluoromethylornithine
-
acaulis5
-
thermospermine
-
trans-4-methylcyclohexylamine
-
gyro
-
kyphoscoliosis
-
agriculture
-
adometdc
-
2.5.1.16
-
medicine
- 2.5.1.22
- polyamine
- putrescine
- s-adenosylmethionine
- ornithine
- aminopropyltransferases
-
snyder-robinson
- alpha-difluoromethylornithine
- acaulis5
- thermospermine
- trans-4-methylcyclohexylamine
-
gyro
-
kyphoscoliosis
- agriculture
- adometdc
-
2.5.1.16
- medicine
Reaction
Synonyms
ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 2.5.1.22 - spermine synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
S-adenosylmethioninamine + spermidine
5'-methylthioadenosine + spermine + H+
Polyamine sythesis, addition of a second aminopropyl group to the N-10 position of spermidine. The active site with a bound spermidine molecule contains an Asp276 residue, which is in an ideal position to facilitate the deprotonation of the N-10 amino group of spermidine that attacks the C-atom of the aminopropyl group of decarboxylated S-adenosylmethionine
-
-
?
S-methyl-5'-thioadenosine + spermine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + spermine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + spermine
-
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + spermine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + spermine
-
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + spermidine
S-methyl-5'-thioadenosine + spermine
-
-
-
-
?
5'-methylthioadenosine + spermine
-
the enzyme, which is involved in the polyamine biosynthetic pathway in producing the final product spermine, is not essential for plant survival under normal growth conditions
-
-
?
S-adenosylmethioninamine + spermidine
5'-methylthioadenosine + spermine
-
involved in polyamine biosynthetic pathway
-
-
?
S-methyl-5'-thioadenosine + spermine
-
decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines
-
-
?
S-adenosylmethioninamine + spermidine
S-methyl-5'-thioadenosine + spermine
-
decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines
-
-
?
?
-
-
levels of spermidine and spermine are not only regulated by activity of spermidine synthase and spermine synthase, but also by other factors, e.g. the level of aminopropyl donor substrate, overview
-
-
?
additional information
?
-
The predominant polyamines in mammalian cells are spermidine and spermine, these polyamines are made by the sequential addition of aminopropyl groups from decarboxylated S-adenosylmethionine.
-
-
?
additional information
?
-
-
spermine synthase is clearly essential for normal development in humans
-
-
?
additional information
?
-
-
spermine synthase is clearly essential for mammalia
-
-
?