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2.5.1.29: geranylgeranyl diphosphate synthase

This is an abbreviated version!
For detailed information about geranylgeranyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.29

Reaction

(2E,6E)-farnesyl diphosphate
+
isopentenyl diphosphate
=
diphosphate
+
geranylgeranyl diphosphate

Synonyms

At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, BTS1, CcGGDPS1, CcGGDPS2, CotB1, CrtE, DR1395, EgcrtE, EuFPS1, EuFPS2, farnesyl diphosphate/geranylgeranyl diphosphate synthase, farnesyl-diphosphate/geranylgeranyldiphosphate, farnesyltransferase, FPPS/GGPPS, geranylgeranyl diphosphate synthase, geranylgeranyl diphosphate synthase 1, geranylgeranyl diphosphate synthase 11, geranylgeranyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase GACE1337, geranylgeranyl pyrophosphate synthase GGPPS1-1, geranylgeranyl pyrophosphate synthase GGPPS1-2, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, geranylgeranyl-pyrophosphate synthase, GGDP synthase, GGDPS, GGPP synthase, GGPP-S, GGPPase, GGPPS, GGPPS 1, GGPPS 191, GGPPS 2, GGPPS 3, GGPPS 595, GGPPS 727, GGPPS1, GGPPS11, GGPS, Ggps1, GGs1, GgsA, GgsB, GGSP1, gps, HpGGPPS, HsGGPPS, IbGGPS, IdsA, isoprenyl diphosphate synthase, leaf-specific geranylgeranyl pyrophosphate synthase, More, PaxG, PfFPPS, PfGGPPS, Saci_0092, short-chain type-III GGPP, synthetase, geranylgeranyl pyrophosphate, TgFPPS, Tk-IdsA, trans-prenyl diphosphate synthase, type II geranylgeranyl diphosphate synthase, type-III geranylgeranyl pyrophosphate synthase, type-III GGPPS

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.29 geranylgeranyl diphosphate synthase

Expression

Expression on EC 2.5.1.29 - geranylgeranyl diphosphate synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
decreasing transcript levels in leafs fully expanded, low expression level in nonphotosynthetic tissues like root
-
enzyme expression is significantly increased in lung adenocarcinoma tissues compared to that in adjacent normal tissues
expression is induced by exogenous methyl jasmonate
expression of geranylgeranyl pyrophosphate synthase, which mediates protein geranylgeranylation, increases in the mouse heart after the onset of placental function
expression of SmGGPPS is inhibited by methyl jasmonate
expression of SmGGPPS is up-regulated by salicylic acid in leaves
high transcript levels in the shoot, increasing transcript levels during leaf development, highest expression in young leaves prior to full
-
overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma
the enzyme is down-regulated in SPCA-1, PC9 and A549 cells using siRNA
the enzyme is up-regulated in A549 cells using an adenoviral vector
the expression of crtE mRNA is not significantly affected by the various light intensities examined when cells are cultured at 25°C under continuous illumination
there might be an association with higher expression of geranylgeranyl diphosphate synthase in the green morph and a relatively higher carotenoid content
-
treatment with methyl jasmonate dramatically increases expression level in sapling
treatment with methyl jasmonate increases expression rate