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2.5.1.29: geranylgeranyl diphosphate synthase

This is an abbreviated version!
For detailed information about geranylgeranyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.29

Reaction

(2E,6E)-farnesyl diphosphate
+
isopentenyl diphosphate
=
diphosphate
 +
geranylgeranyl diphosphate

Synonyms

At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, BTS1, CcGGDPS1, CcGGDPS2, CotB1, CrtE, DR1395, EgcrtE, EuFPS1, EuFPS2, farnesyl diphosphate/geranylgeranyl diphosphate synthase, farnesyl-diphosphate/geranylgeranyldiphosphate, farnesyltransferase, FPPS/GGPPS, geranylgeranyl diphosphate synthase, geranylgeranyl diphosphate synthase 1, geranylgeranyl diphosphate synthase 11, geranylgeranyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase GACE1337, geranylgeranyl pyrophosphate synthase GGPPS1-1, geranylgeranyl pyrophosphate synthase GGPPS1-2, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, geranylgeranyl-pyrophosphate synthase, GGDP synthase, GGDPS, GGPP synthase, GGPP-S, GGPPase, GGPPS, GGPPS 1, GGPPS 191, GGPPS 2, GGPPS 3, GGPPS 595, GGPPS 727, GGPPS1, GGPPS11, GGPS, Ggps1, GGs1, GgsA, GgsB, GGSP1, gps, HpGGPPS, HsGGPPS, IbGGPS, IdsA, isoprenyl diphosphate synthase, leaf-specific geranylgeranyl pyrophosphate synthase, More, PaxG, PfFPPS, PfGGPPS, Saci_0092, short-chain type-III GGPP, synthetase, geranylgeranyl pyrophosphate, TgFPPS, Tk-IdsA, trans-prenyl diphosphate synthase, type II geranylgeranyl diphosphate synthase, type-III geranylgeranyl pyrophosphate synthase, type-III GGPPS

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.29 geranylgeranyl diphosphate synthase

IC50 Value

IC50 Value on EC 2.5.1.29 - geranylgeranyl diphosphate synthase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.086
(((2-(3-((3-fluoro-4-methoxyphenyl)carbamoyl)phenyl)-thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis-(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication, wild-type enzyme
75
(((2-(3-((4-methoxyphenyl)carbamoyl)phenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
0.042
(((2-(3-(4-fluorobenzamido)phenyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication, wild-type enzyme
-
0.085
(((2-(3-(4-methoxybenzamido)phenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
0.1
(((2-(3-(4-methylbenzamido)phenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
0.049
(((2-(3-(phenylcarbamoyl)phenyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
0.064
(((2-(3-benzamidophenyl)thieno[2,3-d]pyrimidin-4-yl)-amino)methylene)bis(phosphonic acid)
0.0022
(2-[1-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-1,2,3-triazol-4-yl]ethane-1,1-diyl)bis(phosphonic acid)
Homo sapiens
-
pH 7.7, 22°C
0.000045
(2-[1-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-1H-1,2,3-triazol-4-yl]ethane-1,1-diyl)bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication
0.0001
(2E,6E)-farnesyl-bis(phosphonic acid)
Homo sapiens
-
pH 7.5, 37°C
0.0003
(2E,6E)-farnesyl-geranyl-bis(phosphonic acid)
Homo sapiens
-
pH 7.5, 37°C
0.0006
(2E,6Z)-farnesyl-bis(phosphonic acid)
Homo sapiens
-
pH 7.5, 37°C
0.0006
(3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
Homo sapiens
-
-
0.04
(3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
Homo sapiens
-
-
0.07
(3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate
Homo sapiens
-
-
0.04
(4aR,10aS)-4a-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one
Homo sapiens
pH 7.5, 23°C
0.0494
(4aR,10aS)-4a-[5-[(1R)-1-aminoethyl]-1,3,4-oxadiazol-2-yl]-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one
Homo sapiens
pH 7.5, 23°C
0.0123
(4bR,8aS)-4b-(5-acetyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
Homo sapiens
pH 7.5, 23°C
0.0109
(4bR,8aS)-4b-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-5,6,7,8,8a,9-hexahydrophenanthrene-3,4,10(4bH)-trione
Homo sapiens
pH 7.5, 23°C
0.0432
(4bR,8aS)-4b-(5-[(1S)-1-[(hydroxymethyl)amino]ethyl]-1,3,4-oxadiazol-2-yl)-8,8-dimethyl-2-(propan-2-yl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-3,4-diol
Homo sapiens
pH 7.5, 23°C
0.006
(6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
Homo sapiens
-
-
0.003
(6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate
Homo sapiens
-
-
0.023
(E)-(2-(1-((3-methyl-3-(4-methylpent-3-en-1-yl)oxiran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)
Homo sapiens
-
pH 7.7, 22°C
0.017
(E)-(2-(1-(3,7-dimethylocta-2,6-dien-1-yl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)
Homo sapiens
-
pH 7.7, 22°C
0.017
(Z)-(2-(1-((3-methyl-3-(4-methylpent-3-en-1-yl)oxiran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)digeranyl bisphosphonate
Homo sapiens
-
pH 7.7, 22°C
0.00038
(Z)-(2-(1-(3,7-dimethylocta-2,6-dien-1-yl)-1H-1,2,3-triazol-4-yl)ethane-1,1-diyl)bis(phosphonate)
Homo sapiens
-
pH 7.7, 22°C
0.007
(Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate
Homo sapiens
-
-
0.00072
1-hydroxydecane-1,1-bisphosphonate
Homo sapiens
-
IC50: 720 nM
0.0147
12-hydroxy-11,20-epoxyabieta-8(14),9(11),12-trien-20-one
Homo sapiens
pH 7.5, 23°C
0.0379
2-[11,12-dihydroxy-20-oxoabieta-8(14),9(11),12-trien-20-yl]hydrazine-1-carboxamide
Homo sapiens
pH 7.5, 23°C
0.0232
6,20-epoxyabieta-8,13-diene-7,11,12,20-tetrone
Homo sapiens
pH 7.5, 23°C
0.0169
7,20-epoxyabieta-8,13-diene-11,12-dione
Homo sapiens
pH 7.5, 23°C
0.0002
bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid)
Homo sapiens
-
pH 7.5, 37°C
0.0002
digeranyl bisphosphonate
0.0144
disodium (1-[bis(sodiooxy)phosphoryl]-3-(5-methylhex-4-enamido)propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0047
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(2E)-3,7-dimethylocta-2,6-dienamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0377
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(2Z)-3,7-dimethylocta-2,6-dienamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0034
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(3R)-3,7-dimethyloct-6-enamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0054
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(3S)-3,7-dimethyloct-6-enamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0037
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(3Z)-4,8-dimethylnona-3,7-dienamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0008
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(4E)-5,9-dimethyldeca-4,8-dienamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0011
disodium (1-[bis(sodiooxy)phosphoryl]-3-[(4Z)-5,9-dimethyldeca-4,8-dienamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0024
disodium (1-[bis(sodiooxy)phosphoryl]-3-[3,7-dimethylocta-2,6-dienamido]propyl)phosphonate
Homo sapiens
pH and temperature not specified in the publication
0.0000619
ibandronate
Plasmodium vivax
-
pH 7.7, 37°C, recombinant PvGGPPS
0.0055
methyl 11,12-dihydroxy-7-(phenylsulfanyl)abieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0354
methyl 11,12-dihydroxy-7-methoxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0436
methyl 11,12-dihydroxy-7-oxoabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0152
methyl 11,12-dihydroxyabieta-8(14),9(11),12-trien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0459
methyl 7-[(2-hydroxyethyl)sulfanyl]-11,12-dioxoabieta-8,13-dien-20-oate
Homo sapiens
pH 7.5, 23°C
0.0154
N-acetyl-S-((4aR,10aS)-5,6-dihydroxy-7-isopropyl-4a-(methoxycarbonyl)-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-9-yl)-L-cysteine
Homo sapiens
pH 7.5, 23°C
0.0378
N-benzyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.0347
N-cycloheptyl-11,12-dihydroxyabieta-8(14),9(11),12-trien-20-amide
Homo sapiens
pH 7.5, 23°C
0.000074 - 0.01
risedronate
0.0375
tert-butyl [(1S)-1-[5-[(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthren-4a(2H)-yl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
Homo sapiens
pH 7.5, 23°C
0.0000433 - 0.1
zoledronate
0.00038
[(6E)-2,6-dimethyl-10-[1-(4-methylpent-3-en-1-yl)-1H-1,2,3-triazol-4-yl]deca-2,6-diene-9,9-diyl]bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication
0.43
[(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid)
1.5
[([6-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidin-4-yl]amino)methylene]bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication, wild-type enzyme
0.0000475
[1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid
Plasmodium vivax
-
pH 7.7, 37°C, recombinant PvGGPPS
0.00043
[2-[1-(4-methylpent-3-en-1-yl)-1H-1,2,3-triazol-4-yl]ethane-1,1-diyl]bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication
0.082
[[(2-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methylene]bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication, wild-type enzyme
0.094
[[(6-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methylene]bis(phosphonic acid)
Homo sapiens
pH and temperature not specified in the publication, wild-type enzyme