2.5.1.3: thiamine phosphate synthase
This is an abbreviated version!
For detailed information about thiamine phosphate synthase, go to the full flat file.
Reaction
+
=
+
+
Synonyms
2-methyl-4-amino-5-hydroxymethylpyrimidinepyrophosphate:4-methyl-5-(2'-phosphoethyl)-thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase, hydroxyethylthiazole kinase/thiamine-phosphate pyrophosphorylase, PF0544, pyrophosphorylase, thiamin phosphate, SSO2532, TH16, THI6, thiamin monophosphate pyrophosphorylase, thiamin phosphate diphosphorylase, thiamin phosphate pyrophosphorylase, thiamin phosphate synthase, thiamin-phosphate pyrophosphorylase, thiamine monophosphate pyrophosphorylase, thiamine phosphate pyrophosphorylase, thiamine phosphate synthase, thiamine-phosphate diphosphorylase, thiamine-phosphate pyrophosphorylase, thiamine-phosphate synthase, thiaminephosphate pyrophosphorylase, ThiE, ThiL, ThiN protein, TM0723, TM1872, TMP pyrophosphorylase, TMP-PPase, TMPPase, TMPS, TPS, YjbQ
ECTree
Inhibitors
Inhibitors on EC 2.5.1.3 - thiamine phosphate synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-methyl-4-amino-5-hydroxymethylpyrimidine
0.1 mM, 6.3% inhibition
2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate
0.1 mM, 18.2% inhibition
3-benzylsulfanyl-phenanthro[9,10-e][1,2,4]triazine
-
IC50 of 0.1 mg/ml
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
uncompetitive
4-[[(2-hydroxy-5-nitrophenyl)methylidene]amino]-5-methyl-2-(propan-2-yl)phenol
-
IC50 of 0.034 mg/ml
5-(2-hydroxyethyl)-4-methylthiazole
0.1 mM, 12.3% inhibition
7-[[4-chloro-6-(diethylamino)-s-triazin-2-yl]amino]-3-phenyl-coumarin
-
IC50 of more than 0.1 mg/ml
PCMB
-
0.01 mM, 98.5% inhibition, inhibition prevented by addition of 2-mercaptoethanol in 10fold molar excess
thiamin
0.1 mM, 17.3% inhibition
thiamin phosphate
0.1 mM, 59% inhibition
acetyl phosphate
-
0.5 mM, 50% inhibition, uncompetitive with respect to both substrates
acetyl phosphate
-
4 mM, 82.8% inhibition
ADP
-
-
ADP
-
4 mM, 42.4% inhibition
ATP
-
uncompetitive with respect to both substrates
ATP
-
4 mM, 64.7% inhibition
ATP
0.1 mM, 12.8% inhibition
CTP
-
-
CTP
-
4 mM, 58.7% inhibition
diphosphate
-
-
diphosphate
-
0.05 mM, 50% inhibition
diphosphate
0.1 mM, 66% inhibition
GTP
-
-
GTP
-
4 mM, 76.7% inhibition
phosphocreatine
-
-
phosphocreatine
-
4 mM, 63.8% inhibition
phosphoenolpyruvate
-
-
phosphoenolpyruvate
-
4 mM, 31.1% inhibition
UTP
-
-
UTP
-
4 mM, 71.6% inhibition