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2.5.1.3: thiamine phosphate synthase

This is an abbreviated version!
For detailed information about thiamine phosphate synthase, go to the full flat file.

Reaction

4-amino-2-methyl-5-(diphosphomethyl)pyrimidine
+
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
=
diphosphate
+
thiamine phosphate
+
CO2

Synonyms

2-methyl-4-amino-5-hydroxymethylpyrimidinepyrophosphate:4-methyl-5-(2'-phosphoethyl)-thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase, hydroxyethylthiazole kinase/thiamine-phosphate pyrophosphorylase, PF0544, pyrophosphorylase, thiamin phosphate, SSO2532, TH16, THI6, thiamin monophosphate pyrophosphorylase, thiamin phosphate diphosphorylase, thiamin phosphate pyrophosphorylase, thiamin phosphate synthase, thiamin-phosphate pyrophosphorylase, thiamine monophosphate pyrophosphorylase, thiamine phosphate pyrophosphorylase, thiamine phosphate synthase, thiamine-phosphate diphosphorylase, thiamine-phosphate pyrophosphorylase, thiamine-phosphate synthase, thiaminephosphate pyrophosphorylase, ThiE, ThiL, ThiN protein, TM0723, TM1872, TMP pyrophosphorylase, TMP-PPase, TMPPase, TMPS, TPS, YjbQ

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.3 thiamine phosphate synthase

Inhibitors

Inhibitors on EC 2.5.1.3 - thiamine phosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-methyl-4-amino-5-hydroxymethylpyrimidine
0.1 mM, 6.3% inhibition
2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate
0.1 mM, 18.2% inhibition
3-benzylsulfanyl-phenanthro[9,10-e][1,2,4]triazine
-
IC50 of 0.1 mg/ml
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
uncompetitive
4-[[(2-hydroxy-5-nitrophenyl)methylidene]amino]-5-methyl-2-(propan-2-yl)phenol
-
IC50 of 0.034 mg/ml
5-(2-hydroxyethyl)-4-methylthiazole
0.1 mM, 12.3% inhibition
7-[[4-chloro-6-(diethylamino)-s-triazin-2-yl]amino]-3-phenyl-coumarin
-
IC50 of more than 0.1 mg/ml
acetyl phosphate
diphosphate
PCMB
-
0.01 mM, 98.5% inhibition, inhibition prevented by addition of 2-mercaptoethanol in 10fold molar excess
phosphocreatine
phosphoenolpyruvate
thiamin
0.1 mM, 17.3% inhibition
thiamin phosphate
0.1 mM, 59% inhibition