2.5.1.31: ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
This is an abbreviated version!
For detailed information about ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific], go to the full flat file.
Word Map on EC 2.5.1.31
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2.5.1.31
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isoprenoids
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cis-prenyltransferase
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prenyltransferases
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dolichols
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luteus
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dhdds
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trans-prenyltransferases
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pharmacology
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octaprenyl
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drug development
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medicine
- 2.5.1.31
-
isoprenoids
- cis-prenyltransferase
- prenyltransferases
- dolichols
- luteus
- dhdds
- trans-prenyltransferases
- pharmacology
-
octaprenyl
- drug development
- medicine
Reaction
Synonyms
bactoprenyl-diphosphate synthase, C55-OO synthetase, C55PP synthetase, cis,polyprenyl diphosphate synthase, cis-prenyl chain elongating enzyme, cis-type undecaprenyl pyrophosphate synthase, CPDS, DDPPs, dehydrodolichyl diphosphate synthase, di-trans,poly-cis-decaprenylcistransferase, di-trans,poly-cis-undecaprenyl-diphosphate synthase, di-trans-poly-cis-decaprenyl cistransferase, isosesquilavandulyl diphosphate synthase, Mcl22, More, synthetase, undecaprenyl pyrophosphate, undecaprenyl diphosphate phosphatase, undecaprenyl diphosphate synthase, undecaprenyl diphosphate synthetase, undecaprenyl pyrophosphate synthase, undecaprenyl pyrophosphate synthetase, undecaprenyl-diphosphate synthase, undecaprenyl-pyrophosphate synthase, UPP synthase, UPP synthetase, UPP, C55 synthase, UPPs, UPS, Z-prenyl diphosphate synthase
ECTree
2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]Advanced search results
results (
results (Activating Compound
Activating Compound on EC 2.5.1.31 - ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
capric acid
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enhancement factor: 0.04 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100
dipalmitoylphosphatidic acid
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enhancement factor: 0.2 in absence of Triton X-100, 1.2 in presence of 0.1% Triton X-100
lauric acid
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enhancement factor: 0.1 in absence of Triton X-100, 2.3 in presence of 0.1% Triton X-100
lysophosphatidylglycerol
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weak effect in activating lipid-depleted enzyme
palmitic acid
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enhancement factor: 0.8 in absence of Triton X-100, 1.4 in presence of 0.1% Triton X-100
phosphatidylserine
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enhancement factor: 0.05 in absence of Triton X-100, 0.4 in presence of 0.1% Triton X-100
stearic acid
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enhancement factor: 0.07 in absence of Triton X-100, 0.8 in presence of 0.1% Triton X-100
trans,trans,trans-geranylgeranyl diphosphate
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stimulates activity with farnesyl diphosphate as substrate
trans,trans-farnesyl diphosphate
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stimulates activity with farnesyl diphosphate as substrate
additional information
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enzyme is inactive in absence of added effectors
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cardiolipin
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Lactobacillus plantarum, Escherichia coli, and bovine cardiolipin. Good activator in absence of detergent
cardiolipin
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from bovine, enhancement factor: 0.8 in absence of Triton X-100, 0.1 in presence of 0.1% Triton X-100
myristic acid
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enhancement factor: 0.2 in absence of Triton X-100, 2.1 in presence of 0.1% Triton X-100
oleic acid
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enhancement factor: 0.9 in absence of Triton X-100, 1.3 in presence of 0.1% Triton X-100
phosphatidic acid
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from egg, good activator in absence of detergent
phosphatidic acid
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enhancement factor: 0.8 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100
Triton
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0.01 microM of UPPs with 5 microM of (2E,6E)-farnesyl diphosphate and 50 microM of isopentenyl diphosphate, 0.5 mM MgCl2, and 50 mM KCl in Hepes buffer (pH 7.5) is 190fold less active (0.013 s-1) for the IPP consumption in the absence of Triton
Triton
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the UPPs steady-state kcat value in the presence of 0.1% Triton is 190fold larger than in the absence of Triton
Triton X-100
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1.5% v/v, 2 molecules are bound in the active site tunnel of the beta-subunit, binding structure
Triton X-100
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no activity in the activation by Triton X-100 is almost saturated at a concentration of 0.02%
Triton X-100
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marked decrease of activity when a small amount of detergent is added, activity gradually increases as further detergent is added, being fully restored when the concentration reaches 2%
