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0.0011 - 0.0015
(2E,6E)-8-(N-methyl-2-aminobenzoyloxy)-3,7-dimethyl-2,6-octandien-1-diphosphate
-
pH 7.5, 25°C
0.00011 - 18
(2E,6E)-farnesyl diphosphate
0.0088 - 0.064
(2E,6E,10E)-geranylgeranyl diphosphate
0.0043 - 18.1
(2Z,6E,10E)-geranylgeranyl diphosphate
0.0588
(2Z,6E,10E,14E)-farnesylgeranyl diphosphate
-
pH 8.5, 37°C
0.0526
(2Z,6Z,10E,14E)-farnesylgeranyl diphosphate
-
pH 8.5, 37°C
0.00017
(E,E)-(2-Diazo-3-trifluoropropionyloxy)geranyl diphosphate
-
pH 7.5, 35°C
0.00013 - 0.103
(E,E)-farnesyl diphosphate
0.008 - 0.037
(E,E,E)-geranylgeranyl diphosphate
0.0189 - 0.305
(Z,E)-farnesyl diphosphate
0.0023 - 0.134
(Z,E,E)-Geranylgeranyl diphosphate
0.0588
(Z,E,E,E)-farnesylgeranyl diphosphate
-
pH 8.5, 37°C
0.0526
(Z,Z,E,E)-farnesylgeranyl diphosphate
-
pH 8.5, 37°C
0.00069
7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate
-
alternative substrate, pH 7.5, 25°C
0.00011 - 0.155
farnesyl diphosphate
0.0032 - 0.036
geranyl diphosphate
0.0003 - 0.0075
geranylgeranyl diphosphate
0.00041 - 252.5
isopentenyl diphosphate
0.0267 - 0.032
neryl diphosphate
additional information
additional information
-
0.00011
(2E,6E)-farnesyl diphosphate
wild-type
0.00011
(2E,6E)-farnesyl diphosphate
wild type, pH 7.5, temperature not specified in the publication
0.00013
(2E,6E)-farnesyl diphosphate
pH 7.5, 35°C
0.00015
(2E,6E)-farnesyl diphosphate
mutant C234A
0.00015
(2E,6E)-farnesyl diphosphate
mutant C234A, pH 7.5, temperature not specified in the publication
0.00017
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, S83(Ala)5 mutant
0.00028
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, H199A mutant
0.00037
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 1 mM MgCl2
0.0004
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C
0.0004
(2E,6E)-farnesyl diphosphate
-
wild-type enzyme, pH 7.5, 25°C
0.0004
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, wild type
0.0004
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type
0.0004
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W91F, pH 7.5, 25°C, wild-type enzyme, pH 7.5, 25°C
0.0004
(2E,6E)-farnesyl diphosphate
-
mutant enzymes E73A, D150A and D218A, pH 7.5, 25°C; wild-type enzyme, pH 7.5, 25°C
0.0004
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, E73A mutant
0.0004
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, E81A mutant
0.0004
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, N74A mutant
0.0004
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, S83(Ala)1 mutant
0.0004
(2E,6E)-farnesyl diphosphate
-
wild type, 25°C, pH 7.5
0.00044
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 3 mM MgCl2
0.00046
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, D26K mutant with 0.5 mM MgCl2
0.0005
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W221F, pH 7.5, 25°C
0.0005
(2E,6E)-farnesyl diphosphate
-
mutant enzyme D26A, pH 7.5, 25°C
0.0005
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, D26A mutant
0.0005
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, DELTAS72 mutant
0.00055
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, D26R mutant with 0.5 mM MgCl2
0.00066
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, H199A/E213A mutant
0.00067
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, D26E mutant with 0.5 mM MgCl2
0.0007
(2E,6E)-farnesyl diphosphate
-
mutant enzyme E213A, pH 7.5, 25°C
0.0007
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W149F, pH 7.5, 25°C
0.0007
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, E213A mutant
0.001
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, DELTAS83 mutant
0.001
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, S71A mutant
0.0015
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 0.05 mM MgCl2
0.0015
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C, W210A mutant
0.00157
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, wild type with 50 mM MgCl2
0.0016
(2E,6E)-farnesyl diphosphate
-
L85A mutant, 25°C, pH 7.5
0.0016
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, R77A mutant
0.0018
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W75F, pH 7.5, 25°C
0.0018
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, DELTAV82S83 mutant
0.002
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W31F, pH 7.5, 25°C
0.0021
(2E,6E)-farnesyl diphosphate
-
L88A mutant, 25°C, pH 7.5
0.0023
(2E,6E)-farnesyl diphosphate
E76Q mutant, pH 7.5, 37°C
0.0026
(2E,6E)-farnesyl diphosphate
-
F89A mutant, 25°C, pH 7.5
0.0028
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C, Y148F mutant
0.003
(2E,6E)-farnesyl diphosphate
-
pH 7.5, 25°C, H43A mutant
0.0032
(2E,6E)-farnesyl diphosphate
pH 7.5, 25°C, W75A mutant
0.0033
(2E,6E)-farnesyl diphosphate
G32R mutant, pH 7.5, 37°C
0.0034
(2E,6E)-farnesyl diphosphate
-
mutant enzyme W207F, pH 7.5, 25°C
0.0036
(2E,6E)-farnesyl diphosphate
wild-type, pH 7.5, 37°C
0.0049
(2E,6E)-farnesyl diphosphate
R42G mutant, pH 7.5, 37°C
0.005
(2E,6E)-farnesyl diphosphate
G32R/R42G mutant, pH 7.5, 37°C
0.0077
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C, Y71S mutant
0.0083
(2E,6E)-farnesyl diphosphate
wild-type, pH 7.5, 37°C
0.0083
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C, wild type
0.0091
(2E,6E)-farnesyl diphosphate
-
pH 8.5, 37°C
0.0092
(2E,6E)-farnesyl diphosphate
wild type, pH 7.5, temperature not specified in the publication
0.0096
(2E,6E)-farnesyl diphosphate
mutant C234A, pH 7.5, temperature not specified in the publication
0.0104
(2E,6E)-farnesyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.0114
(2E,6E)-farnesyl diphosphate
E84Q mutant, pH 7.5, 37°C
0.01213
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C, W224A mutant
0.0139
(2E,6E)-farnesyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.0147
(2E,6E)-farnesyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.0222
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C, F207S mutant
0.0231
(2E,6E)-farnesyl diphosphate
R80A mutant, pH 7.5, 37°C
0.0332
(2E,6E)-farnesyl diphosphate
D29A mutant, pH 7.5, 37°C
0.0495
(2E,6E)-farnesyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.1207
(2E,6E)-farnesyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
0.144
(2E,6E)-farnesyl diphosphate
R33A mutant, pH 7.5, 37°C
0.155
(2E,6E)-farnesyl diphosphate
mutant enzyme N78D, pH 7.5, 37°C
3.5
(2E,6E)-farnesyl diphosphate
D221A mutant, pH 7.3, 37°C
5.4
(2E,6E)-farnesyl diphosphate
E216Q mutant, pH 7.3, 37°C
6.6
(2E,6E)-farnesyl diphosphate
E193Q mutant, pH 7.3, 37°C
8.3
(2E,6E)-farnesyl diphosphate
wild type, pH 7.3, 37°C
9.2
(2E,6E)-farnesyl diphosphate
F73A mutant, pH 7.3, 37°C
9.6
(2E,6E)-farnesyl diphosphate
S74A mutant, pH 7.3, 37°C
11.2
(2E,6E)-farnesyl diphosphate
D226A mutant, pH 7.3, 37°C
11.6
(2E,6E)-farnesyl diphosphate
E201Q mutant, pH 7.3, 37°C
13.6
(2E,6E)-farnesyl diphosphate
R203S mutant, pH 7.3, 37°C
18
(2E,6E)-farnesyl diphosphate
R197S mutant, pH 7.3, 37°C
0.0088
(2E,6E,10E)-geranylgeranyl diphosphate
wild-type, pH 7.5, 37°C
0.0093
(2E,6E,10E)-geranylgeranyl diphosphate
-
pH 8.5, 37°C
0.064
(2E,6E,10E)-geranylgeranyl diphosphate
R33A mutant, pH 7.5, 37°C
0.0043
(2Z,6E,10E)-geranylgeranyl diphosphate
G32R mutant, pH 7.5, 37°C
0.0045
(2Z,6E,10E)-geranylgeranyl diphosphate
R42G mutant, pH 7.5, 37°C
0.005
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.005
(2Z,6E,10E)-geranylgeranyl diphosphate
D29A mutant, pH 7.5, 37°C
0.0059
(2Z,6E,10E)-geranylgeranyl diphosphate
G32R-R42G mutant, pH 7.5, 37°C
0.006
(2Z,6E,10E)-geranylgeranyl diphosphate
E84Q mutant, pH 7.5, 37°C
0.0061
(2Z,6E,10E)-geranylgeranyl diphosphate
R80A mutant, pH 7.5, 37°C
0.008
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C; mutant enzyme W78D, pH 7.5, 37°C
0.0082
(2Z,6E,10E)-geranylgeranyl diphosphate
wild-type enzyme, pH 7.5, 37°C
0.0082
(2Z,6E,10E)-geranylgeranyl diphosphate
wild-type, pH 7.5, 37°C
0.0089
(2Z,6E,10E)-geranylgeranyl diphosphate
-
37°C, pH 37°C
0.0095
(2Z,6E,10E)-geranylgeranyl diphosphate
R33A mutant, pH 7.5, 37°C
0.0102
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.015
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
0.0154
(2Z,6E,10E)-geranylgeranyl diphosphate
-
pH 8.5, 37°C
0.019
(2Z,6E,10E)-geranylgeranyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.023
(2Z,6E,10E)-geranylgeranyl diphosphate
E76Q mutant, pH 7.5, 37°C
5.3
(2Z,6E,10E)-geranylgeranyl diphosphate
S74A mutant, pH 7.3, 37°C
5.8
(2Z,6E,10E)-geranylgeranyl diphosphate
E216Q mutant, pH 7.3, 37°C
6
(2Z,6E,10E)-geranylgeranyl diphosphate
R197S mutant, pH 7.3, 37°C
7.5
(2Z,6E,10E)-geranylgeranyl diphosphate
D226A mutant, pH 7.3, 37°C
8.1
(2Z,6E,10E)-geranylgeranyl diphosphate
E193Q mutant, pH 7.3, 37°C
8.1
(2Z,6E,10E)-geranylgeranyl diphosphate
R203S mutant, pH 7.3, 37°C
8.2
(2Z,6E,10E)-geranylgeranyl diphosphate
wild type, pH 7.3, 37°C
9.4
(2Z,6E,10E)-geranylgeranyl diphosphate
F73A mutant, pH 7.3, 37°C
17.7
(2Z,6E,10E)-geranylgeranyl diphosphate
E201Q mutant, pH 7.3, 37°C
18.1
(2Z,6E,10E)-geranylgeranyl diphosphate
D221A mutant, pH 7.3, 37°C
0.00013
(E,E)-farnesyl diphosphate
pH 7.5, 35°C
0.00013
(E,E)-farnesyl diphosphate
-
pH 7.5, 35°C
0.007
(E,E)-farnesyl diphosphate
-
pH 7.4, 35°C
0.008
(E,E)-farnesyl diphosphate
-
-
0.0091
(E,E)-farnesyl diphosphate
-
-
0.0091
(E,E)-farnesyl diphosphate
-
pH 8.5, 37°C
0.103
(E,E)-farnesyl diphosphate
-
pH 7.5, 35°C
0.008
(E,E,E)-geranylgeranyl diphosphate
-
pH 7.5, 35°C
0.0093
(E,E,E)-geranylgeranyl diphosphate
-
pH 8.5, 37°C
0.037
(E,E,E)-geranylgeranyl diphosphate
-
pH 7.5, 35°C
0.0189
(Z,E)-farnesyl diphosphate
-
pH 8.5, 37°C
0.305
(Z,E)-farnesyl diphosphate
-
pH 7.5, 35°C
0.0023
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme E76Q, pH 7.5, 37°C
0.0043
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme G32R, pH 7.5, 37°C
0.0045
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme R42G, pH 7.5, 37°C
0.005
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.005
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme D29A, pH 7.5, 37°C
0.0053
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme S74A, pH 7.3, 37°C
0.0058
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme R216Q, pH 7.3, 37°C
0.0059
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme G32R/R42G, pH 7.5, 37°C
0.006
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme R197S, pH 7.3, 37°C
0.006
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme E84Q, pH 7.5, 37°C
0.0061
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme R80A, pH 7.5, 37°C
0.008
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.008
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.0081
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme E193Q, pH 7.3, 37°C
0.0081
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme R203S, pH 7.3, 37°C
0.0082
(Z,E,E)-Geranylgeranyl diphosphate
wild-type enzyme, pH 7.5, 37°C
0.0082
(Z,E,E)-Geranylgeranyl diphosphate
wild-type enzyme, pH 7.3, 37°C
0.0094
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme F73A, pH 7.3, 37°C
0.0095
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme R33A, pH 7.5, 37°C
0.0102
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.015
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
0.0154
(Z,E,E)-Geranylgeranyl diphosphate
-
pH 8.5, 37°C
0.0177
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme E201Q, pH 7.3, 37°C
0.0181
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme D221A, pH 7.3, 37°C
0.019
(Z,E,E)-Geranylgeranyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.134
(Z,E,E)-Geranylgeranyl diphosphate
-
pH 7.5, 35°C
0.00011
farnesyl diphosphate
wild-type, pH 7.5
0.00015
farnesyl diphosphate
mutant C234A, pH 7.5
0.0003
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A
0.0004
farnesyl diphosphate
-
wild-type enzyme, pH 7.5, 25°C
0.0004
farnesyl diphosphate
wild-type enzyme, pH 7.5, 25°C
0.0004
farnesyl diphosphate
-
wild-type enzyme, pH 7.5, 25°C
0.0004
farnesyl diphosphate
-
mutant enzymes E73A, D150A and D218A, pH 7.5, 25°C
0.0004
farnesyl diphosphate
mutant enzyme E73A, N74A and E81A, pH 7.5, 25°C
0.0004
farnesyl diphosphate
-
mutant enzyme W91F, pH 7.5, 25°C
0.0004
farnesyl diphosphate
-
pH 7.5, 25°C, wild-type enzyme
0.0004
farnesyl diphosphate
pH 7.5, 25°C, wild-type enzyme
0.0004
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant wild-type enzyme
0.00046
farnesyl diphosphate
pH 7.5, 25°C, mutant D26K
0.0005
farnesyl diphosphate
-
mutant enzyme W221F, pH 7.5, 25°C
0.0005
farnesyl diphosphate
-
mutant enzyme D26A, pH 7.5, 25°C
0.0005
farnesyl diphosphate
pH 7.5, 25°C, mutant D26A
0.0005
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant D26A
0.00055
farnesyl diphosphate
pH 7.5, 25°C, mutant D26R
0.00066
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A/E213A
0.00067
farnesyl diphosphate
pH 7.5, 25°C, mutant D26E
0.0007
farnesyl diphosphate
-
pH 7.5, 30°C
0.0007
farnesyl diphosphate
-
mutant enzyme E213A, pH 7.5, 25°C
0.0007
farnesyl diphosphate
-
mutant enzyme W149F, pH 7.5, 25°C
0.0007
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant E213A
0.001
farnesyl diphosphate
mutant enzyme S71A, pH 7.5, 25°C
0.0015
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant W210A
0.0016
farnesyl diphosphate
mutant enzyme R77A, pH 7.5, 25°C
0.0016
farnesyl diphosphate
-
pH 7.5, 25°C, mutant L85A
0.0018
farnesyl diphosphate
-
mutant enzyme W75F, pH 7.5, 25°C
0.002
farnesyl diphosphate
-
mutant enzyme W31F, pH 7.5, 25°C
0.0021
farnesyl diphosphate
-
pH 7.5, 25°C, mutant L88A
0.0023
farnesyl diphosphate
mutant enzyme E76Q, pH 7.5, 37°C
0.0026
farnesyl diphosphate
-
pH 7.5, 25°C, mutant F89A
0.0028
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.003
farnesyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H43A
0.0032
farnesyl diphosphate
mutant enzyme W75A, pH 7.5, 25°C
0.0033
farnesyl diphosphate
mutant enzyme G32R, pH 7.5, 37°C
0.0034
farnesyl diphosphate
-
mutant enzyme W207F, pH 7.5, 25°C
0.0035
farnesyl diphosphate
mutant enzyme D221A, pH 7.3, 37°C
0.0036
farnesyl diphosphate
wild-type enzyme, pH 7.5, 37°C
0.0049
farnesyl diphosphate
mutant enzyme R42G, pH 7.5, 37°C
0.005
farnesyl diphosphate
mutant enzyme G32R/R42G, pH 7.5, 37°C
0.0054
farnesyl diphosphate
mutant enzyme R216Q, pH 7.3, 37°C
0.0066
farnesyl diphosphate
mutant enzyme E193Q, pH 7.3, 37°C
0.0077
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant Y71S
0.0083
farnesyl diphosphate
wild type enzyme
0.0083
farnesyl diphosphate
wild-type enzyme, pH 7.3, 37°C
0.0083
farnesyl diphosphate
wild-type, pH 7.5, 37°C
0.0083
farnesyl diphosphate
pH 7.5, 30°C, recombinant wild-type enzyme
0.0092
farnesyl diphosphate
mutant enzyme F73A, pH 7.3, 37°C
0.0093
farnesyl diphosphate
mutant enzyme F73A
0.0096
farnesyl diphosphate
mutant enzyme S74A, pH 7.3, 37°C
0.0104
farnesyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.0112
farnesyl diphosphate
mutant enzyme D226A, pH 7.3, 37°C
0.0114
farnesyl diphosphate
mutant enzyme E84Q, pH 7.5, 37°C
0.0116
farnesyl diphosphate
mutant enzyme E201Q, pH 7.3, 37°C
0.0136
farnesyl diphosphate
mutant enzyme R203S, pH 7.3, 37°C
0.0139
farnesyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.014
farnesyl diphosphate
mutant enzyme A72L/F73L/W78L
0.0147
farnesyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.018
farnesyl diphosphate
mutant enzyme R197S, pH 7.3, 37°C
0.022
farnesyl diphosphate
pH 7.5, 30°C, recombinant mutant F207S
0.0231
farnesyl diphosphate
mutant enzyme R80A, pH 7.5, 37°C
0.026
farnesyl diphosphate
mutant enzyme A72L/F73L
0.0332
farnesyl diphosphate
mutant enzyme D29A, pH 7.5, 37°C
0.0495
farnesyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.1207
farnesyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
0.144
farnesyl diphosphate
mutant enzyme R33A, pH 7.5, 37°C
0.155
farnesyl diphosphate
mutant enzyme N78D, pH 7.5, 37°C
0.0032
geranyl diphosphate
-
pH 7.5, 35°C
0.036
geranyl diphosphate
-
25°C, pH 7.5
0.0003
geranylgeranyl diphosphate
-
pH 7.5, 25°C, wild-type enzyme
0.0003
geranylgeranyl diphosphate
-
wild type, 25°C, pH 7.5
0.0007
geranylgeranyl diphosphate
-
pH 7.5, 25°C, mutant L88A
0.0007
geranylgeranyl diphosphate
-
L88A mutant, 25°C, pH 7.5
0.001
geranylgeranyl diphosphate
-
pH 7.5, 25°C, mutant F89A
0.001
geranylgeranyl diphosphate
-
F89A mutant, 25°C, pH 7.5
0.0012
geranylgeranyl diphosphate
-
pH 7.5, 25°C, mutant L85A
0.0012
geranylgeranyl diphosphate
-
L85A mutant, 25°C, pH 7.5
0.0075
geranylgeranyl diphosphate
mutant enzyme D226A, pH 7.3, 37°C
0.00041
isopentenyl diphosphate
pH 7.5, 25°C, wild-type enzyme
0.0009
isopentenyl diphosphate
pH 7.5, 25°C, mutant D26K
0.0014
isopentenyl diphosphate
pH 7.5, 25°C, mutant D26A
0.00192
isopentenyl diphosphate
pH 7.5, 35°C
0.00192
isopentenyl diphosphate
-
pH 7.5, 35°C
0.0021
isopentenyl diphosphate
pH 7.5, 25°C, mutant D26E
0.0022
isopentenyl diphosphate
pH 7.5, 25°C, mutant D26R
0.004
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant wild-type enzyme
0.0041
isopentenyl diphosphate
-
pH 7.5, 25°C
0.0041
isopentenyl diphosphate
pH 7.5, 25°C
0.0041
isopentenyl diphosphate
-
pH 7.5, 25°C
0.0041
isopentenyl diphosphate
-
wild-type enzyme, pH 7.5, 25°C
0.0041
isopentenyl diphosphate
-
pH 7.5, 25°C, wild type
0.0041
isopentenyl diphosphate
pH 7.5, 25°C, wild type
0.0041
isopentenyl diphosphate
-
pH 7.5, 25°C, wild-type enzyme, with farnesyl diphosphate
0.0041
isopentenyl diphosphate
-
wild type, with (2E,6E)-farnesyl diphosphate, 25°C, pH 7.5
0.0044
isopentenyl diphosphate
-
mutant enzyme D218A, pH 7.5, 25°C
0.0059
isopentenyl diphosphate
-
mutant enzyme W31F, pH 7.5, 25°C
0.0059
isopentenyl diphosphate
mutant enzyme G32R/R42G, pH 7.5, 37°C
0.0059
isopentenyl diphosphate
G32R/R42G mutant, pH 7.5, 37°C
0.006
isopentenyl diphosphate
mutant enzyme G32R, pH 7.5, 37°C
0.006
isopentenyl diphosphate
G32R mutant, pH 7.5, 37°C
0.0072
isopentenyl diphosphate
-
mutant enzyme W91F, pH 7.5, 25°C
0.0078
isopentenyl diphosphate
wild-type enzyme, pH 7.5, 37°C
0.0078
isopentenyl diphosphate
wild-type enzyme, pH 7.3, 37°C
0.0078
isopentenyl diphosphate
wild-type, pH 7.5, 37°C
0.0078
isopentenyl diphosphate
pH 7.5, 30°C, recombinant wild-type enzyme
0.0078
isopentenyl diphosphate
-
pH 7.5, 25°C, S83(Ala)5 mutant
0.0078
isopentenyl diphosphate
pH 7.5, 30°C, wild type
0.008
isopentenyl diphosphate
mutant enzyme N74A, pH 7.5, 25°C
0.008
isopentenyl diphosphate
pH 7.5, 25°C, N74A mutant
0.0085
isopentenyl diphosphate
-
37°C, pH 37°C
0.009
isopentenyl diphosphate
mutant enzyme N77Q, pH 7.5, 37°C
0.0092
isopentenyl diphosphate
wild-type
0.0092
isopentenyl diphosphate
wild-type, pH 7.5
0.0092
isopentenyl diphosphate
pH 7.5, 25°C, D26K mutant with 0.5 mM MgCl2
0.0096
isopentenyl diphosphate
mutant C234A, pH 7.5
0.0096
isopentenyl diphosphate
mutant C234A
0.0097
isopentenyl diphosphate
pH 7.5, 25°C, wild type with 1 mM MgCl2
0.0114
isopentenyl diphosphate
mutant enzyme E76Q, pH 7.5, 37°C
0.0114
isopentenyl diphosphate
E76Q mutant, pH 7.5, 37°C
0.0115
isopentenyl diphosphate
pH 7.5, 25°C, wild type with 0.05 mM MgCl2
0.0117
isopentenyl diphosphate
-
pH 7.5, 25°C, DELTAS72 mutant
0.012
isopentenyl diphosphate
mutant enzyme N77A, pH 7.5, 37°C
0.013
isopentenyl diphosphate
-
pH 7.5, 25°C, wild-type enzyme, with geranylgeranyl diphosphate
0.013
isopentenyl diphosphate
-
wild type, with geranylgeranyl diphosphate, 25°C, pH 7.5
0.0131
isopentenyl diphosphate
mutant enzyme W78D, pH 7.5, 37°C
0.014
isopentenyl diphosphate
-
pH 7.5, 35°C
0.014
isopentenyl diphosphate
-
mutant enzyme W221F, pH 7.5, 25°C
0.014
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant D26A
0.0141
isopentenyl diphosphate
-
mutant enzyme D26A, pH 7.5, 25°C
0.0141
isopentenyl diphosphate
mutant enzyme W78I, pH 7.5, 37°C
0.0141
isopentenyl diphosphate
-
pH 7.5, 25°C, D26A mutant
0.015
isopentenyl diphosphate
mutant enzyme N77D, pH 7.5, 37°C
0.0157
isopentenyl diphosphate
mutant enzyme R77A, pH 7.5, 25°C
0.0157
isopentenyl diphosphate
-
mutant enzyme R77A, pH 7.5, 25°C
0.0157
isopentenyl diphosphate
pH 7.5, 25°C, R77A mutant
0.016
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A
0.016
isopentenyl diphosphate
-
pH 7.5, 25°C, H199A mutant
0.0162
isopentenyl diphosphate
-
-
0.0162
isopentenyl diphosphate
mutant enzyme E73A, pH 7.5, 25°C
0.0162
isopentenyl diphosphate
-
pH 7.5, 25°C, wild type
0.0162
isopentenyl diphosphate
pH 7.5, 25°C, E73A mutant
0.0165
isopentenyl diphosphate
mutant enzyme W78R, pH 7.5, 37°C
0.017
isopentenyl diphosphate
mutant enzyme D4226A, pH 7.3, 37°C
0.0175
isopentenyl diphosphate
pH 7.5, 25°C, wild type with 3 mM MgCl2
0.0175
isopentenyl diphosphate
pH 7.5, 30°C, W210A mutant
0.0177
isopentenyl diphosphate
mutant enzyme D221A, pH 7.3, 37°C
0.018
isopentenyl diphosphate
-
pH 7.5, 25°C, mutant F89A, with geranylgeranyl diphosphate
0.018
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant W210A
0.018
isopentenyl diphosphate
-
F89A mutant, with geranylgeranyl diphosphate, 25°C, pH 7.5
0.0183
isopentenyl diphosphate
mutant enzyme E201Q, pH 7.3, 37°C
0.02
isopentenyl diphosphate
-
mutant enzyme W149F, pH 7.5, 25°C
0.0204
isopentenyl diphosphate
mutant enzyme E193Q, pH 7.3, 37°C
0.0208
isopentenyl diphosphate
pH 7.5, 25°C, D26E mutant with 0.5 mM MgCl2
0.0223
isopentenyl diphosphate
pH 7.5, 25°C, D26R mutant with 0.5 mM MgCl2
0.0229
isopentenyl diphosphate
pH 7.5, 30°C, Y148F mutant
0.023
isopentenyl diphosphate
-
mutant enzyme W207F, pH 7.5, 25°C
0.023
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.0242
isopentenyl diphosphate
mutant enzyme R42G, pH 7.5, 37°C
0.0242
isopentenyl diphosphate
R42G mutant, pH 7.5, 37°C
0.0254
isopentenyl diphosphate
pH 7.5, 30°C, Y71S mutant
0.026
isopentenyl diphosphate
-
mutant enzyme W75F, pH 7.5, 25°C
0.026
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant Y71S
0.027
isopentenyl diphosphate
-
-
0.029
isopentenyl diphosphate
-
pH 7.5, 30°C
0.0307
isopentenyl diphosphate
mutant enzyme E84Q, pH 7.5, 37°C
0.0307
isopentenyl diphosphate
E84Q mutant, pH 7.5, 37°C
0.034
isopentenyl diphosphate
-
pH 7.5, 25°C, S83(Ala)1 mutant
0.0356
isopentenyl diphosphate
pH 7.5, 30°C, W224A mutant
0.036
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant Y148F
0.042
isopentenyl diphosphate
-
pH 7.5, 25°C, mutant L88A, with geranylgeranyl diphosphate
0.042
isopentenyl diphosphate
-
L88A mutant, with geranylgeranyl diphosphate, 25°C, pH 7.5
0.0452
isopentenyl diphosphate
mutant enzyme D29A, pH 7.5, 37°C
0.0452
isopentenyl diphosphate
D29A mutant, pH 7.5, 37°C
0.046
isopentenyl diphosphate
mutant enzyme W75A, pH 7.5, 25°C
0.046
isopentenyl diphosphate
pH 7.5, 25°C, W75A mutant
0.0491
isopentenyl diphosphate
mutant enzyme R80A, pH 7.5, 37°C
0.0491
isopentenyl diphosphate
R80A mutant, pH 7.5, 37°C
0.0561
isopentenyl diphosphate
mutant enzyme R197S, pH 7.3, 37°C
0.06
isopentenyl diphosphate
-
pH 7.5, 25°C, mutant L85A, with geranylgeranyl diphosphate
0.06
isopentenyl diphosphate
-
L85A mutant, with geranylgeranyl diphosphate, 25°C, pH 7.5
0.0621
isopentenyl diphosphate
mutant enzyme R203S, pH 7.3, 37°C
0.063
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H43A
0.063
isopentenyl diphosphate
-
pH 7.5, 25°C, H43A mutant
0.084
isopentenyl diphosphate
-
pH 7.5, 25°C, mutant F89A, with farnesyl diphosphate
0.084
isopentenyl diphosphate
-
F89A mutant, with (2E,6E)-farnesyl diphosphate, 25°C, pH 7.5
0.088
isopentenyl diphosphate
mutant enzyme E81A, pH 7.5, 25°C
0.088
isopentenyl diphosphate
pH 7.5, 25°C, E81A mutant
0.0909
isopentenyl diphosphate
mutant enzyme E216Q, pH 7.3, 37°C
0.103
isopentenyl diphosphate
pH 7.5, 30°C, recombinant mutant F207S
0.1031
isopentenyl diphosphate
pH 7.5, 30°C, F207S mutant
0.1268
isopentenyl diphosphate
mutant enzyme S74A, pH 7.3, 37°C
0.133
isopentenyl diphosphate
mutant enzyme S71A, pH 7.5, 25°C
0.133
isopentenyl diphosphate
pH 7.5, 25°C, S71A mutant
0.173
isopentenyl diphosphate
-
pH 7.5, 25°C, mutant L88A, with farnesyl diphosphate
0.173
isopentenyl diphosphate
-
L88A mutant, with (2E,6E)-farnesyl diphosphate, 25°C, pH 7.5
0.2525
isopentenyl diphosphate
mutant enzyme F73A, pH 7.3, 37°C
0.27
isopentenyl diphosphate
-
mutant enzyme D150A, pH 7.5, 25°C
0.279
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant H199A/E213A
0.279
isopentenyl diphosphate
-
pH 7.5, 25°C, H199A/E213A mutant
0.28
isopentenyl diphosphate
-
mutant enzyme D213A, pH 7.5, 25°C
0.28
isopentenyl diphosphate
-
pH 7.5, 25°C, recombinant mutant E213A
0.28
isopentenyl diphosphate
-
pH 7.5, 25°C, E213A mutant
0.291
isopentenyl diphosphate
pH 7.5, 25°C, wild type with 50 mM MgCl2
0.617
isopentenyl diphosphate
-
pH 7.5, 25°C, mutant L85A, with farnesyl diphosphate
0.617
isopentenyl diphosphate
-
L85A mutant, with (2E,6E)-farnesyl diphosphate, 25°C, pH 7.5
7.8
isopentenyl diphosphate
wild type, pH 7.3, 37°C
17
isopentenyl diphosphate
D226A mutant, pH 7.3, 37°C
17.7
isopentenyl diphosphate
D221A mutant, pH 7.3, 37°C
18.3
isopentenyl diphosphate
E201Q mutant, pH 7.3, 37°C
20.4
isopentenyl diphosphate
E193Q mutant, pH 7.3, 37°C
56.1
isopentenyl diphosphate
R197S mutant, pH 7.3, 37°C
62.1
isopentenyl diphosphate
R203S mutant, pH 7.3, 37°C
90.9
isopentenyl diphosphate
E216Q mutant, pH 7.3, 37°C
126.8
isopentenyl diphosphate
S74A mutant, pH 7.3, 37°C
252.5
isopentenyl diphosphate
F73A mutant, pH 7.3, 37°C
0.0267
neryl diphosphate
-
pH 8.5, 37°C
0.032
neryl diphosphate
-
pH 7.5, 35°C
additional information
additional information
-
steady-state kinetics
-
additional information
additional information
-
steady-state kinetics, single turnover measurements with substrate geranylgeranyl diphosphate
-
additional information
additional information
-
fluorescence-based UPPS kinetic measurements, kinetics of the single-turnover reaction of (2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate chain elongation catalyzed by UPPS, overview
-
additional information
additional information
-
pre-steady-state UPPS kinetics, single-turnover, kinetic analysis, overview
-
2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
results (
results (
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