2.5.1.34: 4-dimethylallyltryptophan synthase

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For detailed information about 4-dimethylallyltryptophan synthase, go to the full flat file.

Reaction

Synonyms

4-(gamma,gamma-dimethylallyl)tryptophan synthase, 4-dimethylallyltryptophan synthase, 4-DMATS, 7-dimethylallyltryptophan synthase, 7-DMATS, C4-prenyltransferase, dimethylallyl-tryptophan synthase, dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase, dimethylallylpyrophosphate:tryptophan dimethylallyl transferase, dimethylallylpyrophosphate:tryptophan dimethylallyltransferase, dimethylallyltransferase, tryptophan, dimethylallyltryptophan synthase, dimethylallyltryptophan synthetase, DMAT synthase, DMAT synthetase, DMATS, DmaW, DmaW2, FgaPT2, IfgA, MaPT, Proq05g069320, tryptophan C4-prenyltransferase, tryptophan C4-prenyltransferase FgaPT2, tryptophan C4-PT

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.34 4-dimethylallyltryptophan synthase

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Results	in table
79	AA Sequence
6	Application
1	CAS Registry Number
17	Cloned(Commentary)
5	Crystallization (Commentary)
27	General Information
1	General Stability
37	Inhibitors
14	kcat/KM [mM/s]
1	Ki Value [mM]
64	KM Value [mM]
1	Localization
28	Metals/Ions
17	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
56	Organism
3	Pathway
20	PDB ID
14	pH Optimum
37	Protein Variants
14	Purification (Commentary)
14	Reaction
3	Reaction Type
37	Reference
5	Source Tissue
4	Specific Activity [micromol/min/mg]
3	Storage Stability
214	Substrates and Products (Substrate)
9	Subunits
58	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
53	Turnover Number [1/s]

Application

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Application on EC 2.5.1.34 - 4-dimethylallyltryptophan synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

Aspergillus fumigatus

-

the combination of the two dimethylallyltryptophan synthases FgaPT2 and 7-DMATS (EC 2.5.1.34 and EC 2.5.1.80) can be successfully used for chemoenzymatic synthesis of the diprenylated derivatives. The potential of recombinant enzymes from secondary metabolite biosynthesis as promising tools for the production of designed compounds is demonstrated

701952

synthesis

4 entries

additional information

Aspergillus fumigatus

-

prenyltransferases of the dimethylallyl-tryptophan synthase superfamily catalyze Friedel-Crafts alkylation with high flexibility for aromatic substrates, but the high specificity for dimethylallyl diphosphate prohibits their application as biocatalysts

723326

synthesis

Claviceps purpurea

-

prenyltransferases of the DMATS superfamily are successfully used for production of prenylated compounds including analogues of their natural substrates such as simple indoles, tryptophan-containing cyclic dipeptides, and tyrosine derivatives, overview

723104

synthesis

Aspergillus fumigatus

-

prenyltransferases of the DMATS superfamily are successfully used for production of prenylated compounds including analogues of their natural substrates such as simple indoles, tryptophan-containing cyclic dipeptides, and tyrosine derivatives, overview

723104

synthesis

Malbranchea aurantiaca

-

prenyltransferases of the DMATS superfamily are successfully used for production of prenylated compounds including analogues of their natural substrates such as simple indoles, tryptophan-containing cyclic dipeptides, and tyrosine derivatives, overview

723104

synthesis

Aspergillus fumigatus

Q50EL0

possibility of producing prenylated analogues of ardeemin fumiquinazoline, a precursor of the multidrug resistance (MDR) export pump inhibitor ardeemin, by using dimethylallydiphosphate transferase enzymes, e.g. 4-DMATS, overview

737407