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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
dimethylallyl diphosphate + L-tryptophan
diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
additional information
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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r
dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
first key step in ergot alkaloid biosynthesis providing the pharmaceutically relevant compounds lysergic acid, ergotamine, fumigaclavine A-C, festuclavine, and elymoclavine
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
C-4 prenylation
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
the enzyme is involved in the biosynthesis of the ergot alkaloids fumigaclavines
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
the enzyme is involved in the biosynthesis of the ergot alkaloids fumigaclavines
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
dimethylallyltryptophan synthase catalyzes both normal and reverse prenylation at C3 of the indole ring and normal prenylation of N1
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
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dimethylallyl diphosphate + L-tryptophan
diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
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first pathway-specific enzyme of ergot alkaloid biosynthesis
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dimethylallyl diphosphate + L-tryptophan
diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
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first pathway-specific enzyme of ergot alkaloid biosynthesis
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FgaPT2 catalyzes prenylation of L-tryptophan at C-4 of the indole ring and function as 4-DMATS
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DmaW catalyzes prenylation of L-tryptophan at C-4 of the indole ring and function as 4-DMATS
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4-DMATS catalyzes normal prenylation at C4 of L-tryptophan. When C4 is blocked, 4-DMATS catalyzes alkylation at all of the activated positions, except weakly activated C6, depending on the electron-donating properties of the blocking substituent. In addition, both normal and reverse prenylation is seen at C3 for 4-methyltryptophan. The high regioselectivity for C4 alkylation with the normal substrates suggests that binding and catalysis of a single conformation has been optimized for synthesis of 4-dimethylallyltryptophan, but when alkylation at C4 is blocked, alkylation from other conformations becomes competitive
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4-DMATS catalyzes normal prenylation at C4 of L-tryptophan. When C4 is blocked, 4-DMATS catalyzes alkylation at all of the activated positions, except weakly activated C6, depending on the electron-donating properties of the blocking substituent. In addition, both normal and reverse prenylation is seen at C3 for 4-methyltryptophan. The high regioselectivity for C4 alkylation with the normal substrates suggests that binding and catalysis of a single conformation has been optimized for synthesis of 4-dimethylallyltryptophan, but when alkylation at C4 is blocked, alkylation from other conformations becomes competitive
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MaPT catalyzes prenylation of L-tryptophan at C-4 of the indole ring and function as 4-DMATS
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