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2.5.1.39: 4-hydroxybenzoate polyprenyltransferase

This is an abbreviated version!
For detailed information about 4-hydroxybenzoate polyprenyltransferase, go to the full flat file.

Word Map on EC 2.5.1.39

Reaction

a polyprenyl diphosphate
+
4-hydroxybenzoate
=
diphosphate
 +
a 4-hydroxy-3-polyprenylbenzoate

Synonyms

4-hydroxybenzoate octaprenyl transferase, 4-hydroxybenzoate octaprenyltransferase, 4-hydroxybenzoate polyprenyl diphosphate transferase, 4-hydroxybenzoate transferase, 4-hydroxybenzoate:polyprenyl transferase, 4-hydroxybenzoic acid oligoprenyltransferase, 4-para-hydroxybenzoate:polyprenyl transferase, 4-parahydroxybenzoate: polyprenyl transferase, 4HPT, COQ2, Coq2p, dimethylallyltransferase, p-hydroxybenzoate poly-, nonaprenyl-4-hydroxybenzoate transferase, NPHB transferase, OH-benzoate polyprenyltransferase, ORF3, OsPPT1a, p-hydroxybenzoate dimethylallyltransferase, p-hydroxybenzoate polyprenyltransferase, p-hydroxybenzoate:octaprenyltransferase, p-hydroxybenzoate:polyprenyl transferase, p-hydroxybenzoate:polyprenyltransferase, p-hydroxybenzoic acid-polyprenyl transferase, p-hydroxybenzoic-polyprenyl transferase, para-hydroxybenzoate-polyprenyl transferase, PHB-polyprenyltransferase, polyprenyl 4-hydroxybenzoate transferase, PPT, SmPPT, ubiA

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.39 4-hydroxybenzoate polyprenyltransferase

Cloned

Cloned on EC 2.5.1.39 - 4-hydroxybenzoate polyprenyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloned under control of different promoters, expressed in Nicotiana tabacum
-
expressed in Escherichia coli
-
expressed in Saccharomyces cerevisiae
-
gene cluster consisting of ubiC gene and a portion of ubiA is cloned and expressed in Escherichia coli
-
gene COQ2, complementation of yeast Coq2 null mutant cells
-
gene COQ2, DNA and amino acid sequence determination and analysis, functional expression in and complementation of yeast Coq2 null mutant cells, CoQ biosynthesis rate is lower in the yeast cells when rescued with the human enzyme compared to cells rescued with the yeast enzyme
gene COQ2, DNA and amino acid sequence determination and analysis, genotyping
gene PPT1, DNA and amino acid sequence determination and analysis, functional expression in and complementation of Saccharomyces cerevisiae and Schizosaccharomyces pombe enzyme null mutant cells, expression as GFP-fusion protein in Arabidopsis plants
overexpressed in Escherichia coli
-
the function of SmPPT was analyzed by a yeast complementation system using the yeast coq2 mutant (YNR041C). pYES2-SmPPT was constructed by sub-cloning of the SmPPT open-reading frame (ORF) into the empty D-galactose-inducible expression vector pYES2-CT. pYES2-CT and pYES2-SmPPT are introduced into YNR041C