2.5.1.39: 4-hydroxybenzoate polyprenyltransferase
This is an abbreviated version!
For detailed information about 4-hydroxybenzoate polyprenyltransferase, go to the full flat file.
Word Map on EC 2.5.1.39
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2.5.1.39
-
prenylation
-
chorismate
-
pyruvate-lyase
-
geranylated
-
ubica
-
medicine
- 2.5.1.39
-
prenylation
- chorismate
-
pyruvate-lyase
-
geranylated
-
ubica
- medicine
Reaction
Synonyms
4-hydroxybenzoate octaprenyl transferase, 4-hydroxybenzoate octaprenyltransferase, 4-hydroxybenzoate polyprenyl diphosphate transferase, 4-hydroxybenzoate transferase, 4-hydroxybenzoate:polyprenyl transferase, 4-hydroxybenzoic acid oligoprenyltransferase, 4-para-hydroxybenzoate:polyprenyl transferase, 4-parahydroxybenzoate: polyprenyl transferase, 4HPT, COQ2, Coq2p, dimethylallyltransferase, p-hydroxybenzoate poly-, nonaprenyl-4-hydroxybenzoate transferase, NPHB transferase, OH-benzoate polyprenyltransferase, ORF3, OsPPT1a, p-hydroxybenzoate dimethylallyltransferase, p-hydroxybenzoate polyprenyltransferase, p-hydroxybenzoate:octaprenyltransferase, p-hydroxybenzoate:polyprenyl transferase, p-hydroxybenzoate:polyprenyltransferase, p-hydroxybenzoic acid-polyprenyl transferase, p-hydroxybenzoic-polyprenyl transferase, para-hydroxybenzoate-polyprenyl transferase, PHB-polyprenyltransferase, polyprenyl 4-hydroxybenzoate transferase, PPT, SmPPT, ubiA
ECTree
2.5.1.39 4-hydroxybenzoate polyprenyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.5.1.39 - 4-hydroxybenzoate polyprenyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxybenzoate + solanesyl-diphosphate
4-hydroxy-3-nonaprenylbenzoate + diphosphate
i.e.all-trans nonaprenyl diphosphate
-
-
?
a polyprenyl diphosphate + 4-hydroxybenzoate
diphosphate + a 4-hydroxy-3-polyprenylbenzoate
farnesyl diphosphate + 4-hydroxybenzoate
3-farnesyl-4-hydroxybenzoate + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 4-hydroxybenzoate
3-geranylgeranyl-4-hydroxybenzoate + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 4-hydroxybenzoate
geranylgeranyl-4-hydroxybenzoate + diphosphate
hexaprenyl diphosphate + 4-hydroxybenzoate
hexaprenyl-4-hydroxybenzoate + diphosphate
-
at 68% of the activity with nonaprenyl diphosphate
-
-
?
octaprenyl diphosphate + 4-hydroxybenzoate
4-hydroxy-3-octaprenylbenzoate + diphosphate
-
-
-
-
?
pentaprenyl diphosphate + 4-hydroxybenzoate
pentaprenyl-4-hydroxybenzoate + diphosphate
-
86% of the activity with nonaprenyl diphosphate
-
-
?
phytyl diphosphate + 4-hydroxybenzoate
phytyl-4-hydroxybenzoate + diphosphate
-
at 1% of the activity with nonaprenyl diphosphate
-
-
?
tetraprenyl diphosphate + 4-hydroxybenzoate
tetraprenyl-4-hydroxybenzoate + diphosphate
-
6% of the activity with nonaprenyl diphosphate
-
-
?
a polyprenyl diphosphate + 4-hydroxybenzoate
diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
-
-
-
?
a polyprenyl diphosphate + 4-hydroxybenzoate
diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
Coq2 is quite unspecific with regard to its substrates
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
diphosphate + decaprenyl-4-hydroxybenzoate
preferred substrate
-
-
?
decaprenyl diphosphate + 4-hydroxybenzoate
diphosphate + decaprenyl-4-hydroxybenzoate
-
-
-
-
?
farnesyl diphosphate + 4-hydroxybenzoate
farnesyl-4-hydroxybenzoate + diphosphate
-
-
-
?
farnesyl diphosphate + 4-hydroxybenzoate
farnesyl-4-hydroxybenzoate + diphosphate
-
at 1% of the activity with nonaprenyl diphosphate
-
-
?
geranyl diphosphate + 4-hydroxybenzoate
3-geranyl-4-hydroxybenzoate + diphosphate
-
-
-
-
?
geranyl diphosphate + 4-hydroxybenzoate
3-geranyl-4-hydroxybenzoate + diphosphate
-
-
-
?
geranyl diphosphate + 4-hydroxybenzoate
3-geranyl-4-hydroxybenzoate + diphosphate
-
-
-
-
?
geranyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-geranyl-4-hydroxybenzoate
-
-
-
?
geranyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-geranyl-4-hydroxybenzoate
-
-
-
-
?
geranyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-geranyl-4-hydroxybenzoate
-
-
-
-
?
geranylgeranyl diphosphate + 4-hydroxybenzoate
geranylgeranyl-4-hydroxybenzoate + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 4-hydroxybenzoate
geranylgeranyl-4-hydroxybenzoate + diphosphate
-
various derivatives of 4-hydroxybenzoate can be used as substrate
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
3-nonaprenyl-4-hydroxybenzoate
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
involved in the biosynthesis of ubiquinone
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
involved in biosynthesis of ubiquinone and vitamin E
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
-
-
-
ir
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
3-nonaprenyl-4-hydroxybenzoate
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
i.e. nonaprenyl diphosphate
small amounts of decaprenyl-4-hydroxybenzoate and octaprenylhydroxybenzoate can be found, depending on source of enzyme and substrate used to provide polyprenyl side chains
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
key enzyme in ubiquinone synthesis, it catalyzes the step which brings together the precursor of the benzoquinone ring and the polyisoprenoid side chain, in rat liver the major product is 3-nonaprenyl-4-hydroxybenzoate, in human and guinea pig it is 3-decaprenyl-4-hydroxybenzoate
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
involved in the biosynthesis of ubiquinone
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
-
-
-
ir
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
involved in the biosynthesis of ubiquinone
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 3-solanesyl-4-hydroxybenzoate
-
-
-
-
ir
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 4-hydroxy-3-nonaprenylbenzoate
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + 4-hydroxy-3-nonaprenylbenzoate
-
i.e. all-trans nonaprenyl diphosphate
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
?
solanesyl diphosphate + 4-hydroxybenzoate
diphosphate + nonaprenyl-4-hydroxybenzoate
-
-
-
-
?
additional information
?
-
key enzyme in biosynthesis of ubiquinone, the enzyme is required for embryo development
-
-
?
additional information
?
-
-
key enzyme in biosynthesis of ubiquinone, the enzyme is required for embryo development
-
-
?
additional information
?
-
enzyme shows broad substrate specificity in terms of prenyl substrates
-
-
?
additional information
?
-
-
enzyme shows broad substrate specificity in terms of prenyl substrates
-
-
?
additional information
?
-
-
detergents can affect the specificity of the mitochondrial system synthesizing polyprenyl diphosphates
-
-
?
additional information
?
-
-
in the presence of Mg2+ the enzyme is also able to hydrolyze geranyl diphosphate without forming geranylgeranyl-4-hydroxybenzoate
-
-
?
additional information
?
-
-
one active site selected to be the most likely one for the docking of oligoprenyl diphosphate and 4-hydroxybenzoic acid is located near the N-terminus of the enzyme. An additional highly conserved region in the amino acid sequence of the ubiA enzyme is detected, which can be considered a putative active site
-
-
?
additional information
?
-
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
-
-
?
additional information
?
-
the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group
-
-
?
additional information
?
-
-
decaprenyl diphosphate and 4-hydroxybenzoate are condensed in a reaction catalyzed by 4-hydroxybenzoate:polyprenyl transferase, i.e. COQ2
-
-
?
additional information
?
-
-
detergents can affect the specificity of the mitochondrial system synthesizing polyprenyl diphosphates
-
-
?
additional information
?
-
-
the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone
-
-
?
additional information
?
-
-
the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group
-
-
?
