2.5.1.42: geranylgeranylglycerol-phosphate geranylgeranyltransferase

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For detailed information about geranylgeranylglycerol-phosphate geranylgeranyltransferase, go to the full flat file.

Reaction

Synonyms

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, geranylgeranyltransferase II, geranylgeranyltransferase, geranylgeranyloxyglycerol phosphate, UbiA-2 protein

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.42 geranylgeranylglycerol-phosphate geranylgeranyltransferase

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Results	in table
1065	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
3	General Information
3	Localization
4	Metals/Ions
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
32	Organism
5	Pathway
10	PDB ID
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
2	Source Tissue
7	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.5.1.42 - geranylgeranylglycerol-phosphate geranylgeranyltransferase

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SYSTEMATIC NAME

IUBMB Comments

geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase

This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [2]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 [CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase] to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [2].