2.5.1.46: deoxyhypusine synthase

This is an abbreviated version!
For detailed information about deoxyhypusine synthase, go to the full flat file.

Word Map on EC 2.5.1.46

2.5.1.46

polyamine

gc7

homospermidine

pyrrolizidine

n1-guanyl-1,7-diaminoheptane

nepsilon-4-amino-2-hydroxybutyllysine

aminobutylation

hypusine-containing

1,7-diaminoheptane

deoxyhypusine-containing

butylamine

polyamine-derived

eif-4d

medicine

1,3-diaminopropane

triamine

wolff

drug development

analysis

Reaction

Synonyms

CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.46 deoxyhypusine synthase

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Results	in table
3209	AA Sequence
7	Application
6	CAS Registry Number
35	Cloned(Commentary)
42	Cofactor
5	Crystallization (Commentary)
80	Disease/ Diagnostics
71	General Information
1	General Stability
2	IC50 Value
108	Inhibitors
22	Ki Value [mM]
40	KM Value [mM]
11	Localization
37	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
231	Organism
45	PDB ID
15	pH Optimum
3	pH Range
1	pI Value
3	Posttranslational Modification
57	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
108	Reference
71	Source Tissue
14	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
34	Subunits
84	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

Purification

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Purification on EC 2.5.1.46 - deoxyhypusine synthase

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4 entries

recombinant enzyme

2 entries

recombinant His-tagged DHSL20 and DHS34 from Escherichia coli by metal affinity chromatography

Leishmania donovani

B5APK2

704694

recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and desalting gel filtration

Trichomonas vaginalis

F1AQF9

737787

recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) to homogeneity by nickel affinity chromatography

Cryptosporidium parvum

A3FQA5

739026

recombinant His-tagged enzyme from Escherichia coli strain BL21-CodonPlus (DE3) by nickel affinity chromatography and ultrafiltration, followed by cleavage of the His-tag through protease 3C and elimination via affinity chromatography

Arabidopsis thaliana

Q9FI94

738298

recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and gel filtration

Trypanosoma brucei brucei

Q38BX0, Q4GZD1

738579

recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity cromatography and gel filtration

Trypanosoma brucei brucei

Q38BX0, Q4GZD1

738579

recombinant soluble His-tagged enzyme from Escherichia coli strain Rosetta (DE3)

Theileria parva

Q4UDC3

737840

using Ni-NTA chromatography

3 entries