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2.5.1.47: cysteine synthase

This is an abbreviated version!
For detailed information about cysteine synthase, go to the full flat file.

Word Map on EC 2.5.1.47

Reaction

O-acetyl-L-serine
+
hydrogen sulfide
=
L-cysteine
 +
acetate

Synonyms

(OAS-TL)-like protein, acetylserine sulfhydrylase, At-OASS, ATCC 23270 protein, BAbS19_I09950, beta-cyano-alanine synthase, beta-cyano-L-alanine synthase, CS-A, CS-B, CS1, CS26, CS3, CSase, CSase A, CSase B, CSaseLP, CSC, Cys synthase complex, cysK, CysK1, CysK2, CYSL, CysL-1, cysl-2, CysM, Cysteine synthase, cysteine synthase 1, cysteine synthase A, cysteine synthase B, cysteine synthase, chloroplastic/chromoplastic, cysteine synthase, mitochondrial, cysteine synthetase, DcsD, EC 4.2.99.8, EhCS, EhCS1, EhCS3, EhOASS, Fn1220, GmOAS-TL1, GmOAS-TL2, GmOAS-TL3, GmOAS-TL4, GmOAS-TL6, GmOAS-TL7, GmOASTL4, GsOAS-TL1, GYY4137, HiOASS, HiOASS-A, lanthionine synthase, LbrCS, MCSA1, Nt-OAS-TL, O -acetylserine (thiol)-lyase, O-acetyl-L-serine (thiol) lyase, O-acetyl-L-serine acetate-lyase (adding hydrogen sulfide), O-acetyl-L-serine sulfhydrylase, O-acetyl-L-serine sulfhydrylase B, O-acetyl-L-serine sulfohydrolase, O-acetyl-L-serine(thiol)lyase, O-acetyl-serine (thiol) lyase, O-acetylserine (thiol) lyase, O-acetylserine (Thiol)-lyase, O-acetylserine (thiol)-lyase A, O-acetylserine (thiol)-lyase B, O-acetylserine (thiol)lyase, O-acetylserine sulfhydrylase, O-acetylserine sulfhydrylase A, O-acetylserine sulfhydrylase B, O-acetylserine sulfhydrylase isoenzyme B, O-acetylserine sulfhydrylase-A, O-acetylserine sulfhydrylase-B, O-acetylserine thiol lyase, O-acetylserine(thiol)lyase, O-acetylserine-(thiol)lyase, O-acetylserine-O-acetylhomoserine sulfhydro-lyase, O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase, OAS Shase, OAS thiol-lyases, OAS-TL, OAS-TL A, OAS-TL B, OAS-TL C, OASA1, OASB, OASS, OASS-A, OASS-B, OASTL, OASTL-A, OASTL-A1, old3-1, OPSS, Os01g0290600, Os03g53650, protein ONSET OF LEAF DEATH 3, RCS3, S-sulfocysteine synthase, SSC synthase, StOASTL A, StOASTL B, sulfhydrylase/cysteine synthase, synthase, cysteine, TvCS1

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.47 cysteine synthase

Application

Application on EC 2.5.1.47 - cysteine synthase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
-
dehydration stress enhances the activity of enzyme OASTL, as well as Cys content by 20.0% and 25.6%, respectively. The treatment of NaHS plus dehydration stress enhances OASTL activity and Cys content by 20.7% and 22.9%, respectively, compared with the stressed plants. The inclusion of H2S scavenger hypotaurine slows down the activity of OASTL by 27.9. A similar inhibitory effect of hypotaurine is also noticed on Cys content, which exhibits a 31.9% lower value than the stressed seedlings
analysis
development of a primary cell-based phenotypic screening in both the presence and absence of L-cysteine and selection hits that show differential amebicidal effects between the two conditions
biotechnology
-
transgenic plants expressing serine acetyltransferase and cysteine synthase can mitigate detrimental effects of cadmium toxicity, perhaps by efficiently producing and accumulating sulfuric compounds
drug development
environmental protection
H2S is a major environmental pollutant, highly toxic to living organisms at high concentrations. Even at low concentrations, it causes an unpleasant odor from wetlands, especially from wastewater. Plants can utilize hydrogen sulfide as a sulfur source to synthesize cysteine. It is thus feasible to use aquatic plants, which possess high potential for sulfur assimilation, to remove hydrogen sulfide from the wetland. Transgenic rice plants over-expressing cysteine synthase exhibit 3fold elevated cysteine synthase activity, and incorporate more H2S into cysteine and glutathione than their wild type counterparts upon exposure to a high level of H2S. Overexpression of cysteine synthase in aquatic plants is a viable approach to remove H2S from polluted environments
medicine
pharmacology
-
involved in beta-lactam synthesis
synthesis