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2.5.1.47: cysteine synthase

This is an abbreviated version!
For detailed information about cysteine synthase, go to the full flat file.

Word Map on EC 2.5.1.47

Reaction

O-acetyl-L-serine
+
hydrogen sulfide
=
L-cysteine
 +
acetate

Synonyms

(OAS-TL)-like protein, acetylserine sulfhydrylase, At-OASS, ATCC 23270 protein, BAbS19_I09950, beta-cyano-alanine synthase, beta-cyano-L-alanine synthase, CS-A, CS-B, CS1, CS26, CS3, CSase, CSase A, CSase B, CSaseLP, CSC, Cys synthase complex, cysK, CysK1, CysK2, CYSL, CysL-1, cysl-2, CysM, Cysteine synthase, cysteine synthase 1, cysteine synthase A, cysteine synthase B, cysteine synthase, chloroplastic/chromoplastic, cysteine synthase, mitochondrial, cysteine synthetase, DcsD, EC 4.2.99.8, EhCS, EhCS1, EhCS3, EhOASS, Fn1220, GmOAS-TL1, GmOAS-TL2, GmOAS-TL3, GmOAS-TL4, GmOAS-TL6, GmOAS-TL7, GmOASTL4, GsOAS-TL1, GYY4137, HiOASS, HiOASS-A, lanthionine synthase, LbrCS, MCSA1, Nt-OAS-TL, O -acetylserine (thiol)-lyase, O-acetyl-L-serine (thiol) lyase, O-acetyl-L-serine acetate-lyase (adding hydrogen sulfide), O-acetyl-L-serine sulfhydrylase, O-acetyl-L-serine sulfhydrylase B, O-acetyl-L-serine sulfohydrolase, O-acetyl-L-serine(thiol)lyase, O-acetyl-serine (thiol) lyase, O-acetylserine (thiol) lyase, O-acetylserine (Thiol)-lyase, O-acetylserine (thiol)-lyase A, O-acetylserine (thiol)-lyase B, O-acetylserine (thiol)lyase, O-acetylserine sulfhydrylase, O-acetylserine sulfhydrylase A, O-acetylserine sulfhydrylase B, O-acetylserine sulfhydrylase isoenzyme B, O-acetylserine sulfhydrylase-A, O-acetylserine sulfhydrylase-B, O-acetylserine thiol lyase, O-acetylserine(thiol)lyase, O-acetylserine-(thiol)lyase, O-acetylserine-O-acetylhomoserine sulfhydro-lyase, O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase, OAS Shase, OAS thiol-lyases, OAS-TL, OAS-TL A, OAS-TL B, OAS-TL C, OASA1, OASB, OASS, OASS-A, OASS-B, OASTL, OASTL-A, OASTL-A1, old3-1, OPSS, Os01g0290600, Os03g53650, protein ONSET OF LEAF DEATH 3, RCS3, S-sulfocysteine synthase, SSC synthase, StOASTL A, StOASTL B, sulfhydrylase/cysteine synthase, synthase, cysteine, TvCS1

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.47 cysteine synthase

KI Value

KI Value on EC 2.5.1.47 - cysteine synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.63
5,5'-dithiobis(2-nitrobenzoic) acid
-
pH 6.8, 37 C
160 - 340
acetate
0.8 - 70.92
chloroalanine
2.113 - 48
cysteine
0.004
DYVI
-
pH 7.8, 22°C
2.074 - 2.27
L-cysteine
1.32
L-homoserine
-
pH 6.8, 37 C
6.5
L-methionine
-
pH 7.5, 50 C
1.75
methionine
-
pH 6.8, 37 C
1.03
MNDGI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
2.27
MNEGI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.0387
MNENI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
3.42
MNETI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
15.2
MNKGI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
13.3
MNKVI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.57
MNLGI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.044
MNLNI
wild type serine acetyltransferase motif, 100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
7.1
MNPHI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
3.33
MNVPI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.0249
MNWNI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.0258
MNYDI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.191
MNYFI
100 mM HEPES, pH 8.0, 1 microM enzyme, 20°C, steady state fluorescence titration
0.0608
MNYSI
100 mM HEPES, pH 7.0, 1 microM enzyme, 20°C, steady state fluorescence titration
1.43
N-ethylmaleimide
-
pH 6.8, 37 C
2.3
NaN3
-
pH 7.4, 25 C
7.1 - 18
O-acetyl-L-Ser
19.56 - 32.25
O-acetylserine
2.86
p-chloromercuribenzoate
-
pH 6.8, 37 C
0.011 - 0.11
S2-
additional information
additional information
-
-
-