2.5.1.47: cysteine synthase
This is an abbreviated version!
For detailed information about cysteine synthase, go to the full flat file.
Word Map on EC 2.5.1.47
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2.5.1.47
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h2s
-
sulfur
-
l-cysteine
-
gsh
-
gamma-glutamyl
-
acetyltransferase
-
pyridoxal
-
slow-releasing
-
typhimurium
-
5'-phosphate
-
gasotransmitter
-
o-acetylserinethiollyase
-
nahs
-
sulfite
-
gaseous
-
schiff
-
buthionine
-
sulfoximine
-
phytochelatins
-
assimilatory
-
plp-dependent
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desulfhydrase
-
h2s-releasing
-
alpha-aminoacrylate
-
thiosulfate
-
oxygenase-1
-
gamma-gcs
-
sulphide
-
dl-propargylglycine
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transsulfuration
-
bienzyme
-
3-mercaptopyruvate
-
5'-phosphate-dependent
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beta-synthase
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h2s-producing
-
sulfurylase
-
aldimine
-
beta-replacement
-
gamma-lyase
-
sulfurtransferase
-
cysb
-
hydrosulfide
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biotechnology
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agriculture
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synthesis
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pharmacology
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medicine
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environmental protection
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drug development
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analysis
- 2.5.1.47
- h2s
- sulfur
- l-cysteine
- gsh
-
gamma-glutamyl
- acetyltransferase
- pyridoxal
-
slow-releasing
- typhimurium
- 5'-phosphate
-
gasotransmitter
-
o-acetylserinethiollyase
- nahs
- sulfite
-
gaseous
-
schiff
-
buthionine
- sulfoximine
- phytochelatins
-
assimilatory
-
plp-dependent
- desulfhydrase
-
h2s-releasing
- alpha-aminoacrylate
- thiosulfate
- oxygenase-1
- gamma-gcs
- sulphide
- dl-propargylglycine
-
transsulfuration
-
bienzyme
- 3-mercaptopyruvate
-
5'-phosphate-dependent
- beta-synthase
-
h2s-producing
-
sulfurylase
-
aldimine
-
beta-replacement
-
gamma-lyase
- sulfurtransferase
- cysb
- hydrosulfide
- biotechnology
- agriculture
- synthesis
- pharmacology
- medicine
- environmental protection
- drug development
- analysis
Reaction
Synonyms
(OAS-TL)-like protein, acetylserine sulfhydrylase, At-OASS, ATCC 23270 protein, BAbS19_I09950, beta-cyano-alanine synthase, beta-cyano-L-alanine synthase, CS-A, CS-B, CS1, CS26, CS3, CSase, CSase A, CSase B, CSaseLP, CSC, Cys synthase complex, cysK, CysK1, CysK2, CYSL, CysL-1, cysl-2, CysM, Cysteine synthase, cysteine synthase 1, cysteine synthase A, cysteine synthase B, cysteine synthase, chloroplastic/chromoplastic, cysteine synthase, mitochondrial, cysteine synthetase, DcsD, EC 4.2.99.8, EhCS, EhCS1, EhCS3, EhOASS, Fn1220, GmOAS-TL1, GmOAS-TL2, GmOAS-TL3, GmOAS-TL4, GmOAS-TL6, GmOAS-TL7, GmOASTL4, GsOAS-TL1, GYY4137, HiOASS, HiOASS-A, lanthionine synthase, LbrCS, MCSA1, Nt-OAS-TL, O -acetylserine (thiol)-lyase, O-acetyl-L-serine (thiol) lyase, O-acetyl-L-serine acetate-lyase (adding hydrogen sulfide), O-acetyl-L-serine sulfhydrylase, O-acetyl-L-serine sulfhydrylase B, O-acetyl-L-serine sulfohydrolase, O-acetyl-L-serine(thiol)lyase, O-acetyl-serine (thiol) lyase, O-acetylserine (thiol) lyase, O-acetylserine (Thiol)-lyase, O-acetylserine (thiol)-lyase A, O-acetylserine (thiol)-lyase B, O-acetylserine (thiol)lyase, O-acetylserine sulfhydrylase, O-acetylserine sulfhydrylase A, O-acetylserine sulfhydrylase B, O-acetylserine sulfhydrylase isoenzyme B, O-acetylserine sulfhydrylase-A, O-acetylserine sulfhydrylase-B, O-acetylserine thiol lyase, O-acetylserine(thiol)lyase, O-acetylserine-(thiol)lyase, O-acetylserine-O-acetylhomoserine sulfhydro-lyase, O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase, OAS Shase, OAS thiol-lyases, OAS-TL, OAS-TL A, OAS-TL B, OAS-TL C, OASA1, OASB, OASS, OASS-A, OASS-B, OASTL, OASTL-A, OASTL-A1, old3-1, OPSS, Os01g0290600, Os03g53650, protein ONSET OF LEAF DEATH 3, RCS3, S-sulfocysteine synthase, SSC synthase, StOASTL A, StOASTL B, sulfhydrylase/cysteine synthase, synthase, cysteine, TvCS1
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2.5.1.47 cysteine synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.5.1.47 - cysteine synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cysteine + CN-
cyanoalanine + H2S
Xanthium pennsylvanicum
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involved in cyanide metabolism during seed germination
-
-
?
L-Cys + acetate
?
-
involved in mobilization of sulfide from cysteine for Fe-S cluster formation, significance in vivo unclear
-
-
?
L-cysteine + dithiothreitol
S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S
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the side reaction of the enzyme seems to contribute massively to the total H2S release of higher plants at least at higher pH values
-
-
?
O-acetyl-L-Ser + H2S
L-Cys + acetate
-
enzyme that catalyzes the final step in cysteine biosynthesis. Cysteine synthetase is a global regulator of the expression of genes involved in sulfur assimilation
-
-
?
O-acetyl-L-Ser + H2S
L-Cys + acetate
-
Entamoeba histolytica, the causative agent of human amoebiasis, is essentially anaerobic, requiring a small amount of oxygen for growth. It cannot tolerate the higher concentration of oxygen present in human tissues or blood. However, during tissue invasion it is exposed to a higher level of oxygen, leading to oxygen stress. Cysteine, which is a vital thiol in Entamoeba histolytica, plays an essential role in its oxygen-defence mechanisms. The major route of cysteine biosynthesis in this parasite is the condensation of O-acetylserine with sulfide by the de novo cysteine-biosynthetic pathway, which involves cysteine synthase (EhCS) as a key enzyme
-
-
?
O-acetyl-L-Ser + H2S
L-Cys + acetate
OASTL activity regulates not only Cys de novo synthesis but also its homeostasis
-
-
?
O-acetyl-L-Ser + isoxazolin-5-one
?
-
synthesis of precursor of neurotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid
-
-
?
O-acetyl-L-Ser + isoxazolin-5-one
?
-
synthesis of precursor of neurotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
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the cysteine synthase complex functions as a molecular sensor system that monitors the sulfur status of the cell and controls sulfate assimilation and cysteine synthesis according to the availability of sulfate
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
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last step of assimilatory sulfate reduction
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
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involved in synthesis of antioxidants such as glutathione during fruit development
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
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involved in glutathione formation
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
final step in Cys synthesis
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
final step in Cys synthesis
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
controlled by feedback inhibition, adaptively significant as sulfide removal mechanism
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
final step in Cys synthesis
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
repressed during growth with sulfide or thiosulfide as sulfur source
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
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key role in metabolism of S-containing amino acids
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
functions as a Cys synthase rather than as a homocysteine synthase in vivo
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
enzyme transcription repressed by L-cystine, derepressed by limiting sulfide concentrations
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
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involved in thiosulfate assimilation
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-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
final step in Cys synthesis
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
final step in Cys synthesis
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
last step of assimilatory sulfate reduction
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
last step of assimilatory sulfate reduction
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
last step of assimilatory sulfate reduction
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
activity varies between sulfur sources, enzyme formation regulated by L-Cys concentration
-
-
?
O-acetyl-L-Ser + sulfide
L-Cys + acetate
-
last step of assimilatory sulfate reduction
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
Escherichia coli W3110 / ATCC 27325
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-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O3-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
-
?
O3-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
in the absence of sulfide O3-acetyl-L-serine reacts with the cofactor pyridoxal 5'-phosphate to alpha-aminoacrylate intermediate
-
-
?
O3-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
?
O3-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
-
?
O3-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
-
-
-
-
?
additional information
?
-
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enzyme is induced in leaves exposed to salt stress. The results suggest that the plant enzyme is responding to the salt stress by inducing cysteine biosynthesis as a protection against high ion concentrations
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-
?
additional information
?
-
-
model of a dynamic cysteine synthesis system with regulatory function
-
-
?
additional information
?
-
the mitochondrial isozyme OAS-TL C accounts for less than 5% of total OAS-TL activity
-
-
?
additional information
?
-
-
the mitochondrial isozyme OAS-TL C accounts for less than 5% of total OAS-TL activity
-
-
?
additional information
?
-
-
cysteine synthase CysB is the only isoform of physiological importance in Aspergillus nidulans. Starvation-induced cysteine synthase activity is under control of cross-pathway regulation
-
-
?
additional information
?
-
the enzyme is involved in tellurite resistance. OASS is not essential for cysteine biosynthesis
-
-
?
additional information
?
-
-
the enzyme is involved in tellurite resistance. OASS is not essential for cysteine biosynthesis
-
-
?
additional information
?
-
the enzyme is involved in tellurite resistance. OASS is not essential for cysteine biosynthesis
-
-
?
additional information
?
-
-
the enzyme is involved in tellurite resistance. OASS is not essential for cysteine biosynthesis
-
-
?
additional information
?
-
the enzyme shows H2S synthesizing activity, cysteine synthase activity and also L-3-cyanoalanine synthase activity, EC 4.4.1.9
-
-
?
additional information
?
-
-
the enzyme shows H2S synthesizing activity, cysteine synthase activity and also L-3-cyanoalanine synthase activity, EC 4.4.1.9
-
-
?
additional information
?
-
-
stopped-flow fluorescence spectroscopy is used to characterize the interaction of serine acetyltransferase with OASS and in the presence of the physiological regulators cysteine and bisulfide. Cysteine synthase assembly occurs via a two-step mechanism involving rapid formation of an encounter complex between the two enzymes, followed by a slow conformational change. The conformational change likely results from the closure of the active site of OASS upon binding of the serine acetyltransferase C-terminal peptide. Bisulfide stabilizes the cysteine synthase complex mainly by decreasing the back rate of the isomerization step. Cysteine, the product of the OASS reaction and a SAT inhibitor, slightly affects the kinetics of cysteine synthase formation leading to destabilization of the complex
-
-
?
additional information
?
-
-
the enzyme is induced by Al3+. Cysteine synthase may be a key player during Al response/adaptation in rice
-
-
?
