2.5.1.49: O-acetylhomoserine aminocarboxypropyltransferase
This is an abbreviated version!
For detailed information about O-acetylhomoserine aminocarboxypropyltransferase, go to the full flat file.
Word Map on EC 2.5.1.49
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2.5.1.49
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cystathionine
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o-acetylserine
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l-methionine
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4.2.99.10
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o-acetyl-l-serine
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gamma-lyase
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gamma-synthase
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l-homocysteine
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o-succinylhomoserine
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o-acetyltransferase
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beta-synthase
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beta-lyase
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medicine
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synthesis
- 2.5.1.49
- cystathionine
- o-acetylserine
- l-methionine
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4.2.99.10
- o-acetyl-l-serine
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gamma-lyase
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gamma-synthase
- l-homocysteine
- o-succinylhomoserine
- o-acetyltransferase
- beta-synthase
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beta-lyase
- medicine
- synthesis
Reaction
Synonyms
AHS, EC 4.2.99.10, gamma-cyano-alpha-aminobutyric acid synthase, Homocysteine synthase, MetC, methionine synthase, MetY, O-acetyl-L-homoserine (thiol)-lyase, O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, o-acetyl-L-homoserine sulfhydrylase, O-acetylhomoserine sulfhydrolase, O-acetylhomoserine sulfhydrylase, OAH, OAH SHase, OAH SHLase, OAH sulfhydrylase, OAH-OAS sulfhydrylase, oah2 gene product, OAHS, OAS-OAH sulfhydrylase, Q187D4
ECTree
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Application
Application on EC 2.5.1.49 - O-acetylhomoserine aminocarboxypropyltransferase
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medicine
synthesis
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overexpression of gene metY increases the in vitro activity of O-acetylhomoserine aminocarboxypropyltransferase to 1780 mU/mg and is beneficial for methionine production, since the intracellular methionine pool increases 2fold in the engineered strain
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no association of the polymorphisms A2756G in methionine synthase gene, C677T and A1298C in methylenetetrahydrofolate reductase gene, and 2R-3R in thymidylate synthase gene with increased risk for multiple myeloma
medicine
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no significant difference in polymorphism A2756G distribution is observed between controls and patients with esophageal squamous cell carcinoma. There is no association between methionine synthase A2756G polymorphism and the cystathionine beta-synthase 844ins68 insertion polymorphism and cancer of the upper gastrointestinal tract