2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase

This is an abbreviated version!
For detailed information about 3-deoxy-7-phosphoheptulonate synthase, go to the full flat file.

Word Map on EC 2.5.1.54

2.5.1.54

shikimate

chorismate

mutase

4.1.2.15

prephenate

l-phenylalanine

feedback-resistant

feedback-insensitive

l-tyrosine

phenylalanine-sensitive

kdo8ps

8-phosphate

tyrosine-sensitive

tryptophan-sensitive

feedback-inhibited

3-deoxy-d-manno-octulosonate

3-dehydroshikimate

arogfbr

l-tyr

3-deoxy-d-manno-octulosonate-8-phosphate

arogenate

synthesis

agriculture

biotechnology

Reaction

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

Synonyms

2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphoheptanoate aldolase, 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-7-phosphoheptulonate synthase, 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase, 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), aldolase, phospho-2-keto-3-deoxyheptanoate, Aro1A, Aro4, Aro4p, AroA, AroA(Q), aroF, AroFFR, AroG, D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAH7-P synthase (phe), DAH7P, DAH7P synthase, DAH7PS, DAHP synthase, DAHP synthase-phe, DAHP synthase-trp, DAHP synthase-tyr, DAHP(Phe), DAHPS, DAHPS(Tyr), Dax1, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, DHS, DHS1, DS-Co, DS-Mn, EC 4.1.2.15, KDPH synthase, KDPH synthetase, More, mtDAH7Ps, MtDS, NCgl0950 DAHP synthase, NCgl2098 DAHP synthase, Nme-DAH7PS, OsDAHPS, PF1690, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, Phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, phospho-2-oxo-3-deoxyheptonate aldolase, phzC, TmaDAH7PS

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.54 3-deoxy-7-phosphoheptulonate synthase

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Results	in table
18	Activating Compound
55180	AA Sequence
9	Application
1	CAS Registry Number
34	Cloned(Commentary)
22	Crystallization (Commentary)
2	Expression
24	General Information
17	General Stability
9	IC50 Value
247	Inhibitors
26	kcat/KM [mM/s]
31	Ki Value [mM]
146	KM Value [mM]
12	Localization
95	Metals/Ions
74	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
475	Organism
6	Pathway
224	PDB ID
62	pH Optimum
15	pH Range
2	pH Stability
1	pI Value
69	Protein Variants
56	Purification (Commentary)
31	Reaction
3	Reaction Type
146	Reference
4	Renatured (Commentary)
24	Source Tissue
56	Specific Activity [micromol/min/mg]
7	Storage Stability
194	Substrates and Products (Substrate)
53	Subunits
126	Synonyms
1	Systematic Name
41	Temperature Optimum [°C]
4	Temperature Range [°C]
21	Temperature Stability [°C]
60	Turnover Number [1/s]

KM Value

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KM Value on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase

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0.65

(3S)-2-deoxyerythrose 4-phosphate

Escherichia coli

pH 6.8

672576

0.006

2-deoxy-D-erythrose 4-phosphate

Pyrococcus furiosus

Q8U0A9

pH 6.8, 60°C

658097

2.5

2-deoxy-D-ribose 5-phosphate

Pyrococcus furiosus

Q8U0A9

pH 6.8, 60°C

658097

6.8

2-deoxyribose 5-phosphate

Escherichia coli

recombinant enzyme, pH 7.5, 25°C

639774

0.03 - 2.7

D-arabinose 5-phosphate

2 entries

2.5

D-erythrose

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

0.0026 - 52.36

D-erythrose 4-phosphate

53 entries

3.5

D-glyceraldehyde

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

1.58

D-ribose 5-phosphate

Pyrococcus furiosus

Q8U0A9

pH 6.8, 60°C

658097

8.4

D-threose

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

DL-glyceraldehyde 3-phosphate

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

8.6

glycolaldehyde

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

3.6

glyoxylate

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

5.1

L-erythrose

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

3.3

L-glyceraldehyde

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

13.9

L-threose

Spinacia oleracea

cytosolic isozyme DS-Co, pH 8.6, 37°C

639780

0.003 - 21

phosphoenolpyruvate

63 entries

ribose 5-phosphate

Escherichia coli

recombinant enzyme, pH 7.5, 25°C

639774

additional information

17 entries