2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase This is an abbreviated version! For detailed information about 3-deoxy-7-phosphoheptulonate synthase, go to the full flat file .
Reaction
phosphoenolpyruvate +
D-erythrose 4-phosphate +
H2O =
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate +
phosphate
Synonyms 2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphoheptanoate aldolase, 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-7-phosphoheptulonate synthase, 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase, 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), aldolase, phospho-2-keto-3-deoxyheptanoate, Aro1A, Aro4, Aro4p, AroA, AroA(Q), aroF, AroFFR, AroG, D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAH7-P synthase (phe), DAH7P, DAH7P synthase, DAH7PS, DAHP synthase, DAHP synthase-phe, DAHP synthase-trp, DAHP synthase-tyr, DAHP(Phe), DAHPS, DAHPS(Tyr), Dax1, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, DHS, DHS1, DS-Co, DS-Mn, EC 4.1.2.15, KDPH synthase, KDPH synthetase, More, mtDAH7Ps, MtDS, NCgl0950 DAHP synthase, NCgl2098 DAHP synthase, Nme-DAH7PS, OsDAHPS, PF1690, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, Phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, phospho-2-oxo-3-deoxyheptonate aldolase, phzC, TmaDAH7PS
ECTree
Organism
Organism on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase
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UniProt
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UniProt
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UniProt
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wild type strain WV2 contains DS I, a leaky L-Phe-requiring auxotroph mutant strain GH141 grown under L-Phe limitation possesses additional DS II activity
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bifunctional enzyme, catalyzes reactions of EC 2.5.1.54 and EC 5.4.99.5
UniProt
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strain ATCC 17409
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gene aroF
UniProt
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cv. Jimian20, gene GhDHS1
UniProt
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strain ATCC 17724
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strain Tü 24
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strain Tü 24
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serotype B, gene aroG
UniProt
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cytosolic isozyme
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no activity in Homo sapiens
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plastidic isozyme DS-Mn and cytosolic isozyme DS-Co
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UniProt
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tyrosine-sensitive isozyme
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cytosolic isozyme Ds-Co
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metagenomic library from subtropical marine mangrove sediment
UniProt
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Trp-sensitive isozyme
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UniProt
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enzyme is encoded by duplicated genes : DHS1 and DHS2
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2 isozymes: DS-Co and DS-Mn
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cv. JL-24
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bifunctional enzyme, catalyzes reactions of EC 2.5.1.54 and EC 5.4.99.5
UniProt
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Marburg strain and strain 168, bifunctional enzyme with chorismate mutase activity in addition to enzymic activity
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gene aroF
UniProt
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strains ATCC 13032 and RES167
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Tyr-sensitive isozyme
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basonym Alcaligenes eutrophus
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3 enzymes: I, II, and II
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cv. Kurodagosun
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cytosolic isozyme
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i.e. Comamonas terrigena
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strain ATCC 11299a, two distinct regulatory isoenzymes: DAHP synthase-phe and DAHP synthase-tyr
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Swissprot
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Swissprot
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SwissProt
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3 isoenzymes
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deletion mutant strain H80c from strain HfrH
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gene aroG
Swissprot
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isoform AroG
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isoform DAHPS(Phe)
UniProt
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isoform is Tyr-sensitive
SwissProt
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K12
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mutant 83-24
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Phe-sensitive isozyme
Swissprot
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phenylalanine-sensitive isozyme
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phenylalanine-sensitive isozyme
Swissprot
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tryptophan-sensitive isozyme
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tyrosine-sensitive isozyme
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SwissProt
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isoform is Tyr-sensitive
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UniProt
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expression in Escherichia coli
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gene aroG
UniProt
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recombinant protein, coexpression with Escherichia coli chaperonins GroEL and GroES in Escherichia coli
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UniProt
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expression in Escherichia coli
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gene aroG
UniProt
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serotype B, gene aroG
UniProt
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Trp-, Phe- and Tyr-sensitive isoenzymes
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tryptophan-sensitive isozyme
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UniProt
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cv. Onyx
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cytosolic isozyme Ds-Co
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tyrosine-sensitive isozyme
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UniProt
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2 isoenzymes: tyrosine-sensitive DAHP synthase-tyr and tryptophane-sensitive DAHP synthase-trp
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Uniprot
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Uniprot
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Uniprot
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ARO3-encoded isozyme is a phenylalanine-sensitive isozyme
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ARO4-encoded isozyme is a tyrosine-sensitive isozyme
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Phe-sensitive isozyme
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strain strain CEN.PK666-1C
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operator-constitutive strain tyrO
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tyrosine-sensitive isozyme
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cv. Superior
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cytosolic isozyme Ds-Co
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Trp-sensitive isozyme
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Trp-sensitive isozyme
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gene aroF
UniProt
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recombinant enzyme
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2 differentially regulated isozymes: DS-Mn and DS-Co
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2 classes of enzymes: class AroAI and AroAII
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strain ATCC 33436
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