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2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase

This is an abbreviated version!
For detailed information about 3-deoxy-7-phosphoheptulonate synthase, go to the full flat file.

Word Map on EC 2.5.1.54

Reaction

phosphoenolpyruvate
+
D-erythrose 4-phosphate
+
H2O
=
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
+
phosphate

Synonyms

2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphoheptanoate aldolase, 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-7-phosphoheptulonate synthase, 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase, 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), aldolase, phospho-2-keto-3-deoxyheptanoate, Aro1A, Aro4, Aro4p, AroA, AroA(Q), aroF, AroFFR, AroG, D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAH7-P synthase (phe), DAH7P, DAH7P synthase, DAH7PS, DAHP synthase, DAHP synthase-phe, DAHP synthase-trp, DAHP synthase-tyr, DAHP(Phe), DAHPS, DAHPS(Tyr), Dax1, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, DHS, DHS1, DS-Co, DS-Mn, EC 4.1.2.15, KDPH synthase, KDPH synthetase, More, mtDAH7Ps, MtDS, NCgl0950 DAHP synthase, NCgl2098 DAHP synthase, Nme-DAH7PS, OsDAHPS, PF1690, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, Phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, phospho-2-oxo-3-deoxyheptonate aldolase, phzC, TmaDAH7PS

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.54 3-deoxy-7-phosphoheptulonate synthase

Specific Activity

Specific Activity on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.005
-
partially purified isozyme synthase-trp
0.008
-
partially purified isoenzyme DS-Mn
0.026
-
partially purified enzyme
0.056
-
partially purified isozyme synthase-tyr
0.11
-
partially purified isozyme DS-Mn, with Mn2+
0.14
-
partially purified isozyme DS-Co, with Co2+
0.21
-
partially purified isozyme DS-Co
0.27
-
partially purified Tyr-sensitive isozyme
0.29
-
N-terminal deletion mutant, 37°C, pH 6.4
0.4
-
partially purified enzyme
0.8
-
recombinant clone M1 in Escherichia coli strain BL21(DE3)
0.81
-
mutant W215A, 37°C, pH 6.4
0.91
-
purified enzyme
0.92
-
mutant I10A, 37°C, pH 6.4
1.3
-
partially purified enzyme
1.97
-
mutant N5K, 37°C, pH 6.4
10.75
-
purified enzyme
11.02
-
purified Trp-sensitive isozyme
139.3
-
recombinant wild-type
16.4
-
purified enzyme
18.8
-
partially purified cytosolic isozyme, + 10 mM Mg2+
2.1
-
purified enzyme
2.3
-
purified cytosolic isozyme
2.37
-
mutant V221A, 37°C, pH 6.4
2.4
-
partially purified native enzyme
2.7
-
wild-type, 37°C, pH 6.4
22
-
purified recombinant Tyr-sensitive isozyme, with Cd2+
3.07
-
mutant F144A, 37°C, pH 6.4
3.11
-
recombinant clone M2 in Escherichia coli strain BL21(DE3)
3.25
-
mutant F209A, 37°C, pH 6.4
3.6
-
mutant L175Q, 37°C, pH 6.4
30 - 40
-
purified Tyr-sensitive isozyme, wild-type and mutant N8K
4.25
-
mutant L175A, 37°C, pH 6.4
4.46
-
mutant L175D, 37°C, pH 6.4
4.5
-
partially purified Phe-sensitive isozyme
56
-
purified enzyme
67
-
purified enzyme
7.1
-
purified enzyme
7.7
-
purified Trp-sensitive isozyme
7.8
-
purified enzyme
8.1
-
purified Trp-sensitive isozyme
8.24
-
purified recombinant Tyr-sensitive isozyme
8.33
-
purified Trp-sensitive isozyme
82.6
-
purified enzyme
additional information