2.5.1.56: N-acetylneuraminate synthase
This is an abbreviated version!
For detailed information about N-acetylneuraminate synthase, go to the full flat file.
Word Map on EC 2.5.1.56
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2.5.1.56
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n-acetylmannosamine
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antifreeze
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mannac
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meningitidis
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polysialic
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neunacs
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neuroinvasive
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synthesis
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cmp-sialic
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2-epimerase
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ice-binding
- 2.5.1.56
- n-acetylmannosamine
-
antifreeze
- mannac
- meningitidis
-
polysialic
-
neunacs
-
neuroinvasive
- synthesis
-
cmp-sialic
-
2-epimerase
-
ice-binding
Reaction
Synonyms
(NANA) condensing enzyme, EC 4.1.3.19, N-acetylneuraminate lyase synthase, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), N-acetylneuraminic acid condensing enzyme, N-acetylneuraminic acid synthase, NANA condensing enzyme, NANA synthase, NANAS, NANS, NeuAc synthase, NeuB, NeuB1, NeuNAc synthase, NmeNANAS, sialic acid synthase, synthase, N-acetylneuraminate
ECTree
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Reference on EC 2.5.1.56 - N-acetylneuraminate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Masson, L.; Holbein, B.E.
Physiology of sialic acid capsular polysaccharide synthesis in serogroup B Neisseria meningitidis
J. Bacteriol.
154
728-736
1983
Neisseria meningitidis, Neisseria meningitidis PRM102
Blacklow, R.S.; Warren, L.
Biosynthesis of sialic acids by Neisseria meningitidis
J. Biol. Chem.
237
3520-3526
1962
Neisseria meningitidis
Brossmer, R.; Rose, U.
Enzymic synthesis of 5-acetamido-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-2-nonulosonic acid, a 9-azido-9-deoxy derivative of N-acetylneuraminic acid
Biochem. Biophys. Res. Commun.
96
1282-1289
1980
Neisseria meningitidis, Neisseria meningitidis 60E
Vann, W.F.; Tavarez, J.J.; Crowley, J.; Vimr, E.; Silver, R.P.
Purification and characterization of the Escherichia coli K1 neuB gene product N-acetylneuraminic acid synthetase
Glycobiology
7
697-701
1997
Escherichia coli, Escherichia coli K1
Komaki, E.; Ohta, Y.; Tsukada, Y.
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12
Biosci. Biotechnol. Biochem.
61
2046-2050
1997
Escherichia coli, Escherichia coli K1-M12
Tabata, K.; Koizumi, S.; Endo, T.; Ozaki, A.
Production of N-acetyl-D-neuraminic acid by coupling bacteria expressing N-acetyl-D-glucosamine 2-epimerase and N-acetyl-D-neuraminic acid synthetase
Enzyme Microb. Technol.
30
327-333
2002
Escherichia coli
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Hwang, T.S.; Hung, C.H.; Teo, C.F.; Chen, G.T.; Chang, L.S.; Chen, S.F.; Chen, Y.J.; Lin, C.H.
Structural characterization of Escherichia coli sialic acid synthase
Biochem. Biophys. Res. Commun.
295
167-173
2002
Escherichia coli
Linton, D.; Karlyshev, A.V.; Hitchen, P.G.; Morris, H.R.; Dell, A.; Gregson, N.A.; Wren, B.W.
Multiple N-acetyl neuraminic acid synthetase (neuB) genes in Campylobacter jejuni: identification and characterization of the gene involved in sialylation of lipo-oligosaccharide
Mol. Microbiol.
35
1120-1134
2000
Campylobacter jejuni, Campylobacter jejuni NCTC
Suryanti, V.; Nelson, A.; Berry, A.
Cloning, over-expression, purification, and characterization of N-acetylneuraminate synthase from Streptococcus agalactiae
Protein Expr. Purif.
27
346-356
2003
Streptococcus agalactiae
Sundaram, A.K.; Pitts, L.; Muhammad, K.; Wu, J.; Betenbaugh, M.; Woodard, R.W.; Vann, W.F.
Characterization of N-acetylneuraminic acid synthase isoenzyme 1 from Campylobacter jejuni
Biochem. J.
383
83-89
2004
Campylobacter jejuni
Huang, H.H.; Liao, H.K.; Chen, Y.J.; Hwang, T.S.; Lin, Y.H.; Lin, C.H.
Structural characterization of sialic acid synthase by electrospray mass spectrometry--a tetrameric enzyme composed of dimeric dimers
J. Am. Soc. Mass Spectrom.
16
324-332
2005
Escherichia coli, Streptococcus agalactiae
Gunawan, J.; Simard, D.; Gilbert, M.; Lovering, A.L.; Wakarchuk, W.W.; Tanner, M.E.; Strynadka, N.C.
Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol
J. Biol. Chem.
280
3555-3563
2005
Neisseria meningitidis
Hao, J.; Balagurumoorthy, P.; Sarilla, S.; Sundaramoorthy, M.
Cloning, expression, and characterization of sialic acid synthases
Biochem. Biophys. Res. Commun.
338
1507-1514
2005
Neisseria meningitidis
Fierfort, N.; Samain, E.
Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides
J. Biotechnol.
134
261-265
2008
Campylobacter jejuni (Q93MP9)
Liu, F.; Lee, H.J.; Strynadka, N.C.; Tanner, M.E.
Inhibition of Neisseria meningitidis sialic acid synthase by a tetrahedral intermediate analogue
Biochemistry
48
9194-9201
2009
Neisseria meningitidis (E0NCD4), Neisseria meningitidis
Ishikawa, M.; Koizumi, S.
Microbial production of N-acetylneuraminic acid by genetically engineered Escherichia coli
Carbohydr. Res.
345
2605-2609
2010
Escherichia coli
Joseph, D.D.; Jiao, W.; Parker, E.J.
Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis
Biochemistry
52
2609-2619
2013
Neisseria meningitidis (H2VFG5), Neisseria meningitidis, Neisseria meningitidis MC58 (H2VFG5)
Berg, T.O.; Gurung, M.K.; Altermark, B.; Smalas, A.O.; Raeder, I.L.
Characterization of the N-acetylneuraminic acid synthase (NeuB) from the psychrophilic fish pathogen Moritella viscosa
Carbohydr. Res.
402
133-145
2015
Moritella viscosa (A0A090IMH4), Moritella viscosa
Garcia Garcia, M.I.; Lau, K.; von Itzstein, M.; Garcia Carmona, F.; Sanchez Ferrer, A.
Molecular characterization of a new N-acetylneuraminate synthase (NeuB1) from Idiomarina loihiensis
Glycobiology
25
115-123
2015
Idiomarina loihiensis (Q5R082), Idiomarina loihiensis, Idiomarina loihiensis L2-TR (Q5R082)
van Karnebeek, C.D.; Bonafe, L.; Wen, X.Y.; Tarailo-Graovac, M.; Balzano, S.; Royer-Bertrand, B.; Ashikov, A.; Garavelli, L.; Mammi, I.; Turolla, L.; Breen, C.; Donnai, D.; Cormier, V.; Heron, D.; Nishimura, G.; Uchikawa, S.; Campos-Xavier, B.; Rossi, A.; Hennet, T.; Brand-Arzamendi, K.; Rozmus, J.
NANS-mediated synthesis of sialic acid is required for brain and skeletal development
Nat. Genet.
48
777-784
2016
Danio rerio (Q6P0K4), Homo sapiens (Q9NR45)
Joseph, D.D.; Jiao, W.; Kessans, S.A.; Parker, E.J.
Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase
Proteins
82
2054-2066
2014
Neisseria meningitidis (H2VFG5), Neisseria meningitidis, Neisseria meningitidis MC58 (H2VFG5)
Zhao, L.; Tian, R.; Shen, Q.; Liu, Y.; Liu, L.; Li, J.; Du, G.
Pathway engineering of Bacillus subtilis for enhanced N-acetylneuraminic acid production via whole-cell biocatalysis
Biotechnol. J.
14
1800682
2019
Staphylococcus hominis
Yang, P.; Wang, J.; Pang, Q.; Zhang, F.; Wang, J.; Wang, Q.; Qi, Q.
Pathway optimization and key enzyme evolution of N-acetylneuraminate biosynthesis using an in vivo aptazyme-based biosensor
Metab. Eng.
43
21-28
2017
Escherichia coli, Escherichia coli K1
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