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2.5.1.56: N-acetylneuraminate synthase

This is an abbreviated version!
For detailed information about N-acetylneuraminate synthase, go to the full flat file.

Word Map on EC 2.5.1.56

Reaction

phosphoenolpyruvate
+
N-acetyl-D-mannosamine
 +
H2O
=
phosphate
 +
N-acetylneuraminate

Synonyms

(NANA) condensing enzyme, EC 4.1.3.19, N-acetylneuraminate lyase synthase, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), N-acetylneuraminic acid condensing enzyme, N-acetylneuraminic acid synthase, NANA condensing enzyme, NANA synthase, NANAS, NANS, NeuAc synthase, NeuB, NeuB1, NeuNAc synthase, NmeNANAS, sialic acid synthase, synthase, N-acetylneuraminate

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.56 N-acetylneuraminate synthase

Specific Activity

Specific Activity on EC 2.5.1.56 - N-acetylneuraminate synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000416
-
-
1.018
-
pH 8.0, 37°C
17.93
-
mutant C914T, pH 7.0, 37°C
26.5
-
mutant G1018A, pH 7.0, 37°C
27.47
-
mutant C914T/G1018A, pH 7.0, 37°C
28.11
-
wild-type, pH 7.0, 37°C
28.96
-
mutant G283A, pH 7.0, 37°C
30.76
-
mutant T74C, pH 7.0, 37°C
32.48
-
mutant T74C/A506G, pH 7.0, 37°C
35.71
-
mutant A506G/G420A, pH 7.0, 37°C