2.5.1.57: N-acylneuraminate-9-phosphate synthase

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For detailed information about N-acylneuraminate-9-phosphate synthase, go to the full flat file.

Reaction

Synonyms

DmSAS, EC 4.1.3.20, N-acetylneuraminate 9-phosphate synthase, N-acetylneuraminate-9-phosphate lyase, N-acetylneuraminate-9-phosphate sialic acid 9-phosphate synthase, N-acetylneuraminate-9-phosphate synthetase, N-acetylneuraminic acid 9-phosphate synthase, N-acetylneuraminic acid 9-phosphate synthetase, N-acetylneuraminic acid phosphate synthase, N-acetylneuraminic acid-9-phosphate synthase, N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating), NANS, Neu5Ac 9-phosphate synthase, Neu5Ac 9-phosphate synthetase, neu5ac-9-P synthase, neuac-9-phosphate synthase, NeuNAc phosphate synthase, NeuNAc-9-P synthase, NPS, SAS, sialic acid 9-phosphate synthase, sialic acid synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.57 N-acylneuraminate-9-phosphate synthase

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Results	in table
124	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Disease/ Diagnostics
3	General Stability
14	Inhibitors
15	KM Value [mM]
6	Localization
26	Metals/Ions
15	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
355	Organism
3	Pathway
1	PDB ID
3	pH Optimum
1	pH Range
1	pI Value
3	Protein Variants
8	Purification (Commentary)
1	Reaction
3	Reaction Type
28	Reference
50	Source Tissue
9	Specific Activity [micromol/min/mg]
7	Storage Stability
58	Substrates and Products (Substrate)
6	Subunits
27	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 2.5.1.57 - N-acylneuraminate-9-phosphate synthase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-18°C, crude extract can be stored

Sus scrofa

-

637814

-20°C, crude extract stable for at least 1 month

Sus scrofa

-

637813

0°C, loses approximately 25% of the activity during a 24-h period

Sus scrofa

-

637813

4°C, crude extract retains 60% of enzyme activity when stored for 1 week

Rattus norvegicus

-

637820

4°C, purified enzyme loses activity completely after 1 day in phosphate buffer

Rattus norvegicus

-

637820

4°C, purified enzyme loses approximately half of its activity in 3 days

Sus scrofa

-

637814

4°C, purified enzyme, 50% of enzyme activity remains after 2 days in phosphate buffer containing 5 mM MgCl2, enzyme activity is lost entirely after 3 days

Rattus norvegicus

-

637820