2.5.1.57: N-acylneuraminate-9-phosphate synthase

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For detailed information about N-acylneuraminate-9-phosphate synthase, go to the full flat file.

Reaction

Synonyms

DmSAS, EC 4.1.3.20, N-acetylneuraminate 9-phosphate synthase, N-acetylneuraminate-9-phosphate lyase, N-acetylneuraminate-9-phosphate sialic acid 9-phosphate synthase, N-acetylneuraminate-9-phosphate synthetase, N-acetylneuraminic acid 9-phosphate synthase, N-acetylneuraminic acid 9-phosphate synthetase, N-acetylneuraminic acid phosphate synthase, N-acetylneuraminic acid-9-phosphate synthase, N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating), NANS, Neu5Ac 9-phosphate synthase, Neu5Ac 9-phosphate synthetase, neu5ac-9-P synthase, neuac-9-phosphate synthase, NeuNAc phosphate synthase, NeuNAc-9-P synthase, NPS, SAS, sialic acid 9-phosphate synthase, sialic acid synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.57 N-acylneuraminate-9-phosphate synthase

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Results	in table
124	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Disease/ Diagnostics
3	General Stability
14	Inhibitors
15	KM Value [mM]
6	Localization
26	Metals/Ions
15	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
355	Organism
3	Pathway
1	PDB ID
3	pH Optimum
1	pH Range
1	pI Value
3	Protein Variants
8	Purification (Commentary)
1	Reaction
3	Reaction Type
28	Reference
50	Source Tissue
9	Specific Activity [micromol/min/mg]
7	Storage Stability
58	Substrates and Products (Substrate)
6	Subunits
27	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.5.1.57 - N-acylneuraminate-9-phosphate synthase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

37 - 65

Homo sapiens

Q9NR45

the enzyme loses 43% of its initial KDN-9-P synthetic activity after 10 min at 37°C or 55°C, treatment for 10 min at 65°C results in retention of 26% and 39% of N-acetylneuraminate 9-phosphate and 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid-9-phosphate activity respectively

685801