2.5.1.58: protein farnesyltransferase
This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.
Word Map on EC 2.5.1.58
-
2.5.1.58
-
farnesylation
-
prenylation
-
geranylgeranylation
-
isoprenoids
-
beta-subunits
-
isoprenylation
-
15-carbon
-
lamins
-
manumycin
-
geranylgeranyltransferase-i
-
farnesyl-protein
-
h-ras
-
medicine
-
peptidomimetic
-
prelamin
-
ggtase-i
-
p21ras
-
tetrapeptide
-
farnesol
-
tetrahydroquinoline
-
ras-dependent
-
pharmacology
-
progerin
-
3hmevalonate
-
ras-induced
-
lovastatin
-
tipifarnib
-
drug development
-
ras-mediated
-
ras-transformed
-
lonafarnib
-
hutchinson-gilford
-
dimethylallyl
-
geranylgeraniol
-
isoprene
-
analysis
- 2.5.1.58
-
farnesylation
-
prenylation
-
geranylgeranylation
-
isoprenoids
- beta-subunits
-
isoprenylation
-
15-carbon
- lamins
- manumycin
-
geranylgeranyltransferase-i
-
farnesyl-protein
- h-ras
- medicine
-
peptidomimetic
-
prelamin
- ggtase-i
-
p21ras
- tetrapeptide
- farnesol
- tetrahydroquinoline
-
ras-dependent
- pharmacology
-
progerin
-
3hmevalonate
-
ras-induced
- lovastatin
- tipifarnib
- drug development
-
ras-mediated
-
ras-transformed
- lonafarnib
-
hutchinson-gilford
-
dimethylallyl
- geranylgeraniol
- isoprene
- analysis
Reaction
Synonyms
AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase
ECTree
Advanced search results
KCat KM Value
KCat KM Value on EC 2.5.1.58 - protein farnesyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
60
(2E,6E)-3,7-dimethyl-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
42
(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
380
(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
107
(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
20
(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
9
(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
190
(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
87
(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl trihydrogen diphosphate
-
-
190
(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
40
(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
150
(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
50
(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
150
(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
180
(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
85
(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
170
(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
130
(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
30
(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
60
(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
60
(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
130
(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
170
(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
28
(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
24
(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate
-
-
93
(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
130
(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
115
(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
21
(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
260
(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate
-
-
260
(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
68
(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
350
(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
50
(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
140
(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl diphosphate
-
pH 7.8, 25°C
300
[3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl diphosphate
-
pH 7.8, 25°C
200
-
measured by continuous fluorescence assay
240
(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl diphosphate
-
determined by RP-HPLC product analysis
150
-
determined by continuous fluorescence assay
160
(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl trihydrogen diphosphate
-
determined by RP-HPLC product analysis
0.1
below, with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
0.1
CCIQ
below, with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
4
CCIQ
with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
6.6
CCIQ
with farnesyl diphosphate, pH and temperature not specified in the publication
32
CCIQ
with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication
0.1
below, with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
1.8
CTIQ
with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
4.9
CTIQ
with farnesyl diphosphate, pH and temperature not specified in the publication
12.1
CTIQ
with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
28
CTIQ
with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication
10.8
with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
24
CVIS
with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication
41
CVIS
with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
41
CVIS
with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
59
CVIS
with farnesyl diphosphate, pH and temperature not specified in the publication
1.6
with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
2
CVLS
with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
19
CVLS
with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication
24
CVLS
with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication
47
CVLS
with farnesyl diphosphate, pH and temperature not specified in the publication