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2.5.1.58: protein farnesyltransferase

This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.

Word Map on EC 2.5.1.58

Reaction

farnesyl diphosphate
+
protein-cysteine
=
S-farnesyl protein
+
diphosphate

Synonyms

AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.58 protein farnesyltransferase

KCat KM Value

KCat KM Value on EC 2.5.1.58 - protein farnesyltransferase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
60
(2E,6E)-3,7-dimethyl-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
200 - 240
(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl diphosphate
80
(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
150 - 160
(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl trihydrogen diphosphate
42
(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
380
(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
107
(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
20
(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
9
(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
190
(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
87
(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
-
110
(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl trihydrogen diphosphate
-
-
190
(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
40
(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
150
(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
50
(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
150
(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
180
(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
85
(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
170
(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
130
(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
30
(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
60
(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
60
(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
130
(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
80
(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
170
(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
28
(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
24
(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate
-
-
93
(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
130
(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
115
(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
21
(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
260
(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate
-
-
260
(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
160
(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
68
(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
350
(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
120
(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
50
(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
100
(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
140
(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
-
180 - 193
(2E,6E)-farnesyl diphosphate
110
(E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl diphosphate
-
pH 7.8, 25°C
12
CALQ
-
assay at pH 7.8, 25°C
0.1
CALV
-
assay at pH 7.8, 25°C
44
CAVQ
-
assay at pH 7.8, 25°C
3
CCIF
-
assay at pH 7.8, 25°C
0.32
CCIL
-
assay at pH 7.8, 25°C
0.1 - 32
CCIQ
3.6
CDVK
-
assay at pH 7.8, 25°C
3.1
CEIQ
-
assay at pH 7.8, 25°C
0.6
CFLS
-
assay at pH 7.8, 25°C
4.7
CFPS
-
assay at pH 7.8, 25°C
0.97
CFTN
-
assay at pH 7.8, 25°C
2.1
CFVN
-
assay at pH 7.8, 25°C
0.16
CGIA
-
assay at pH 7.8, 25°C
1.1
CGIM
-
assay at pH 7.8, 25°C
0.45
CGLF
-
assay at pH 7.8, 25°C
1
CGLY
-
assay at pH 7.8, 25°C
0.09
CGVV
-
assay at pH 7.8, 25°C
3.3
CHIM
-
assay at pH 7.8, 25°C
2.2
CHIQ
-
assay at pH 7.8, 25°C
2
CHLM
-
assay at pH 7.8, 25°C
0.46
CHLS
-
assay at pH 7.8, 25°C
10
CHVM
-
assay at pH 7.8, 25°C
4.5
CHVQ
-
assay at pH 7.8, 25°C
0.44
CIVA
-
assay at pH 7.8, 25°C
0.17
CKIF
-
assay at pH 7.8, 25°C
2.8
CKIS
-
assay at pH 7.8, 25°C
0.87
CKIV
-
assay at pH 7.8, 25°C
2.5
CLIT
-
assay at pH 7.8, 25°C
1.7
CLLM
-
assay at pH 7.8, 25°C
0.1
CLLV
-
assay at pH 7.8, 25°C
0.15
CLML
-
assay at pH 7.8, 25°C
0.22
CLTS
-
assay at pH 7.8, 25°C
6
CLVM
-
assay at pH 7.8, 25°C
2.1
CNIM
-
assay at pH 7.8, 25°C
0.17
CNLF
-
assay at pH 7.8, 25°C
6.3
CNLK
-
assay at pH 7.8, 25°C
1
CNLM
-
assay at pH 7.8, 25°C
0.67
CNLQ
-
assay at pH 7.8, 25°C
0.53
CQTA
-
assay at pH 7.8, 25°C
3.8
CRIS
-
assay at pH 7.8, 25°C
0.39
CSFM
-
assay at pH 7.8, 25°C
14
CSIM
-
assay at pH 7.8, 25°C
2.7
CSIS
-
assay at pH 7.8, 25°C
2.5
CSLA
-
assay at pH 7.8, 25°C
0.24
CSLC
-
assay at pH 7.8, 25°C
0.24
CSLG
-
assay at pH 7.8, 25°C
0.21
CSLH
-
assay at pH 7.8, 25°C
1.8
CSLM
-
assay at pH 7.8, 25°C
1.2
CSVQ
-
assay at pH 7.8, 25°C
1.8
CSVS
-
assay at pH 7.8, 25°C
0.092
CTII
-
assay at pH 7.8, 25°C
0.1 - 28
CTIQ
7.2
CTIV
-
assay at pH 7.8, 25°C
4.4
CTKF
-
assay at pH 7.8, 25°C
0.36
CTLA
-
assay at pH 7.8, 25°C
1.1
CTLM
-
assay at pH 7.8, 25°C
1.9
CTLQ
-
assay at pH 7.8, 25°C
0.53
CTMS
-
assay at pH 7.8, 25°C
0.71
CTTQ
-
assay at pH 7.8, 25°C
1.3
CTVF
-
assay at pH 7.8, 25°C
5.8
CTVS
-
assay at pH 7.8, 25°C
2.3
CTVV
-
assay at pH 7.8, 25°C
0.46
CVHF
-
assay at pH 7.8, 25°C
10.8 - 59
CVIS
0.5
CVLA
-
assay at pH 7.8, 25°C
0.15
CVLH
-
assay at pH 7.8, 25°C
0.78
CVLQ
-
assay at pH 7.8, 25°C
1.6 - 47
CVLS
0.27
CVQM
-
assay at pH 7.8, 25°C
0.27
CVVT
-
assay at pH 7.8, 25°C
12
CYIS
-
assay at pH 7.8, 25°C
4.7
CYLA
-
assay at pH 7.8, 25°C
0.9
CYPD
-
assay at pH 7.8, 25°C
2.5
CYVM
-
assay at pH 7.8, 25°C
0.95
dansyl-GCEV
steady state reactivity, pH 7.8, 33°C
1.9
dansyl-GCFT
steady state reactivity, pH 7.8, 33°C
1.4
dansyl-GCII
steady state reactivity, pH 7.8, 33°C
4
dansyl-GCLL
steady state reactivity, pH 7.8, 33°C
1.9
dansyl-GCNV
steady state reactivity, pH 7.8, 33°C
2.5
dansyl-GCQL
steady state reactivity, pH 7.8, 33°C
0.34
dansyl-GCRL
steady state reactivity, pH 7.8, 33°C
1
dansyl-GCSV
steady state reactivity, pH 7.8, 33°C
1.9
dansyl-GCTV
steady state reactivity, pH 7.8, 33°C
3.9
dansyl-GCVAA
-
assay at pH 7.8, 25°C
80
dansyl-GCVAM
-
assay at pH 7.8, 25°C
29
dansyl-GCVAQ
-
assay at pH 7.8, 25°C
35
dansyl-GCVAS
-
assay at pH 7.8, 25°C
1.4
dansyl-GCVCS
-
assay at pH 7.8, 25°C
0.004
dansyl-GCVDA
-
value below, assay at pH 7.8, 25°C
0.004
dansyl-GCVDM
-
assay at pH 7.8, 25°C
0.004
dansyl-GCVDQ
-
assay at pH 7.8, 25°C
0.08
dansyl-GCVDS
-
assay at pH 7.8, 25°C
0.004
dansyl-GCVEA
-
value below, assay at pH 7.8, 25°C
0.7
dansyl-GCVEM
-
assay at pH 7.8, 25°C
0.004
dansyl-GCVEQ
-
assay at pH 7.8, 25°C
0.5
dansyl-GCVES
-
assay at pH 7.8, 25°C
40
dansyl-GCVFA
-
assay at pH 7.8, 25°C
100
dansyl-GCVFM
-
assay at pH 7.8, 25°C
130
dansyl-GCVFQ
-
assay at pH 7.8, 25°C
23
dansyl-GCVFS
-
assay at pH 7.8, 25°C
1.6
dansyl-GCVGA
-
assay at pH 7.8, 25°C
21
dansyl-GCVGM
-
assay at pH 7.8, 25°C
9.4
dansyl-GCVGQ
-
assay at pH 7.8, 25°C
3.5
dansyl-GCVGS
-
assay at pH 7.8, 25°C
1.1
dansyl-GCVHA
-
assay at pH 7.8, 25°C
7
dansyl-GCVHM
-
assay at pH 7.8, 25°C
4
dansyl-GCVHQ
-
assay at pH 7.8, 25°C
1.9
dansyl-GCVHS
-
assay at pH 7.8, 25°C
120
dansyl-GCVIA
-
assay at pH 7.8, 25°C
110
dansyl-GCVIM
-
assay at pH 7.8, 25°C
110
dansyl-GCVIQ
-
assay at pH 7.8, 25°C
130
dansyl-GCVIS
-
assay at pH 7.8, 25°C
0.004
dansyl-GCVKA
-
value below, assay at pH 7.8, 25°C
60
dansyl-GCVKLQ
-
assay at pH 7.8, 25°C
1.3
dansyl-GCVKM
-
assay at pH 7.8, 25°C
1.9
dansyl-GCVKQ
-
assay at pH 7.8, 25°C
0.27
dansyl-GCVKS
-
assay at pH 7.8, 25°C
2.2
dansyl-GCVL
steady state reactivity, pH 7.8, 33°C
70
dansyl-GCVLA
-
assay at pH 7.8, 25°C
250
dansyl-GCVLM
-
assay at pH 7.8, 25°C
170
dansyl-GCVLS
80
dansyl-GCVMA
-
assay at pH 7.8, 25°C
270
dansyl-GCVMM
-
assay at pH 7.8, 25°C
110
dansyl-GCVMQ
-
assay at pH 7.8, 25°C
160
dansyl-GCVMS
-
assay at pH 7.8, 25°C
0.6
dansyl-GCVNA
-
assay at pH 7.8, 25°C
26
dansyl-GCVNM
-
assay at pH 7.8, 25°C
17
dansyl-GCVNQ
-
assay at pH 7.8, 25°C
3.6
dansyl-GCVNS
-
assay at pH 7.8, 25°C
3.4
dansyl-GCVPA
-
assay at pH 7.8, 25°C
30
dansyl-GCVPM
-
assay at pH 7.8, 25°C
12
dansyl-GCVPQ
-
assay at pH 7.8, 25°C
52
dansyl-GCVPS
-
assay at pH 7.8, 25°C
6.8
dansyl-GCVQA
-
assay at pH 7.8, 25°C
10
dansyl-GCVQM
-
assay at pH 7.8, 25°C
32
dansyl-GCVQQ
-
assay at pH 7.8, 25°C
45
dansyl-GCVQs
-
assay at pH 7.8, 25°C
3.2
dansyl-GCVSA
-
assay at pH 7.8, 25°C
70
dansyl-GCVSM
-
assay at pH 7.8, 25°C
33
dansyl-GCVSQ
-
assay at pH 7.8, 25°C
22
dansyl-GCVSS
-
assay at pH 7.8, 25°C
11
dansyl-GCVTA
-
assay at pH 7.8, 25°C
130
dansyl-GCVTM
-
assay at pH 7.8, 25°C
50
dansyl-GCVTQ
-
assay at pH 7.8, 25°C
100
dansyl-GCVTS
-
assay at pH 7.8, 25°C
90
dansyl-GCVVA
-
assay at pH 7.8, 25°C
150
dansyl-GCVVM
-
assay at pH 7.8, 25°C
60
dansyl-GCVVQ
-
assay at pH 7.8, 25°C
320
dansyl-GCVVS
-
assay at pH 7.8, 25°C
10
dansyl-GCVWA
-
assay at pH 7.8, 25°C
70
dansyl-GCVWM
-
assay at pH 7.8, 25°C
50
dansyl-GCVWQ
-
assay at pH 7.8, 25°C
5
dansyl-GCVWS
-
assay at pH 7.8, 25°C
7
dansyl-GCVYA
-
assay at pH 7.8, 25°C
100
dansyl-GCVYM
-
assay at pH 7.8, 25°C
60
dansyl-GCVYQ
-
assay at pH 7.8, 25°C
2.1
dansyl-GCVYS
-
assay at pH 7.8, 25°C
2.6
dansyl-GCWI
steady state reactivity, pH 7.8, 33°C
1.3
dansyl-GCYL
steady state reactivity, pH 7.8, 33°C
15
geranyl diphosphate
-
-
300
[3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl diphosphate
-
pH 7.8, 25°C