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2.5.1.58: protein farnesyltransferase

This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.

Word Map on EC 2.5.1.58

Reaction

farnesyl diphosphate
+
protein-cysteine
=
S-farnesyl protein
 +
diphosphate

Synonyms

AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.58 protein farnesyltransferase

KM Value

KM Value on EC 2.5.1.58 - protein farnesyltransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0512
(2E,6E)-3,7-dimethyl-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0004 - 0.0005
(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl diphosphate
0.002
(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.002
(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.004
(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.00017
(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.004
(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.015
(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0019
(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0003
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0011
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0214
(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0013
(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.01
(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
value above, apparent Michaelis-Menten constant for peptide
0.0023
(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0031
(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0038
(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0013
(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0165
(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0031
(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0025
(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0013
(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0032
(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0021
(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0007
(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0013
(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0005
(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.07
(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.00042
(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0021
(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0001
(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0004
(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0023
(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0187
(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.033
(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0044
(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0045
(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0023
(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0063
(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.001
(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0013
(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.007
(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0009
(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0009
(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.001
(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.001
(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0038
(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.00034
(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0009
(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0043
(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0017
(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0102
(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.00026
(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.0014
(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.03
(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.004
(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.008
(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
-
apparent Michaelis-Menten constant for peptide
0.00076 - 0.0015
(2E,6E)-farnesyl diphosphate
0.0005
(E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl diphosphate
-
pH 7.8, 25°C
0.089
10-benzyloxy-3-methyl-2-decen-1-ol-diphosphate
-
-
0.89
6-benzyloxy-3-methyl-2-hexen-1-ol-diphosphate
-
-
0.13
7-benzyloxy-3-methyl-2-hepten-1-ol-diphosphate
-
-
0.056
8-benzyloxy-3-methyl-2-octen-1-ol-diphosphate
-
-
0.091
9-benzyloxy-3-methyl-2-nonen-1-ol-diphosphate
-
-
0.0003976
AAA-GPP
-
at room temperature
0.0000684
APO-GPP
-
at room temperature
0.003 - 0.011
dansyl-GCVDS
0.0014 - 0.01
dansyl-GCVKS
0.0005 - 0.0018
dansyl-Gly-Cys-Lys-Thr-Gln
0.0007 - 0.0025
dansyl-Gly-Cys-Lys-Val-Leu
0.00014 - 0.00016
dansyl-Gly-Cys-Val-Ile-Met
0.0007
dansyl-Gly-Cys-Val-Leu-Ser
0.00002383 - 0.046
farnesyl diphosphate
0.027
geranyl diphosphate
-
apparent Michaelis-Menten constant for peptide
0.45
geranylgeranyl diphosphate
-
-
0.0051
GST-CIIS
-
-
-
0.0000886
HOM-GPP
-
at room temperature
0.00131
KGCVIM
-
pH 7.5, 25°C
0.00184
KGCVVM
-
pH 7.5, 25°C
0.006
N-dansyl-GCVIA
-
in 50 mM Tris-HCl (pH 7.0) containing 10 mM MgCl2, 0.01 mM ZnCl2, 20 nM enzyme, and 5 mM DTT, at 30°C
0.00032 - 0.00303
YRASNRSCAIM
0.0015
[3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl diphosphate
-
pH 7.8, 25°C
additional information
dansyl-GCVDS