2.5.1.58: protein farnesyltransferase

This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.

Reaction

Synonyms

AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.58 protein farnesyltransferase

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Results	in table
2	Activating Compound
3673	AA Sequence
44	Application
1	CAS Registry Number
37	Cloned(Commentary)
17	Crystallization (Commentary)
412	Disease/ Diagnostics
25	General Information
2	General Stability
420	IC50 Value
974	Inhibitors
240	kcat/KM [mM/s]
26	Ki Value [mM]
114	KM Value [mM]
4	Localization
78	Metals/Ions
36	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
5	Organic Solvent Stability
151	Organism
2	Pathway
114	PDB ID
20	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
59	Protein Variants
30	Purification (Commentary)
18	Reaction
145	Reference
39	Source Tissue
6	Specific Activity [micromol/min/mg]
486	Substrates and Products (Substrate)
30	Subunits
145	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
114	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.5.1.58 - protein farnesyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine

S-(2E,6E)-farnesyl protein + diphosphate

3 entries

(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine

S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate

2 entries

(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine

S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate

2 entries

(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine

S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate

2 entries

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

7 entries

(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine

S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate

2 entries

farnesyl diphosphate + protein-cysteine

diphosphate + S-farnesyl protein

Saccharomyces cerevisiae

-

-

673089

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

19 entries

additional information

?

-

2 entries

(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine

S-(2E,6E)-farnesyl protein + diphosphate

Homo sapiens

P49354, P49356

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine

S-(2E,6E)-farnesyl protein + diphosphate

Rattus norvegicus

Q04631; Q02293

-

737324

-

-

?

(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine

S-(2E,6E)-farnesyl protein + diphosphate

Saccharomyces cerevisiae

P29703; P22007

-

737324

-

-

?

(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine

S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate

Homo sapiens

P49354, P49356

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine

S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate

Rattus norvegicus

Q02293, Q04631

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine

S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate

Homo sapiens

P49354, P49356

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine

S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate

Rattus norvegicus

Q02293, Q04631

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine

S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate

Homo sapiens

P49354, P49356

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine

S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate

Rattus norvegicus

Q02293, Q04631

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Aspergillus fumigatus

-

-

739602

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Candida albicans

Q9Y765

-

737324

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Homo sapiens

-

-

738158, 738969

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Homo sapiens

P49354, P49356

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Rattus norvegicus

Q02293, Q04631

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Rattus norvegicus

Q04631; Q02293

-

737827

-

-

?

(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine

S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate

Trypanosoma brucei

-

-

738158, 738969

-

-

?

(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine

S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate

Homo sapiens

P49354, P49356

-

738097

-

-

?

(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine

S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate

Rattus norvegicus

Q02293, Q04631

-

738097

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Homo sapiens

-

-

637523

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Homo sapiens

-

process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics

637505, 637506

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Homo sapiens

-

process necessary for the subcellular localisation of substrate to the plasma membrane

637505, 637506

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Homo sapiens

-

the enzyme catalyzes posttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions

658829

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Mus musculus

-

protein farnesylation is essential for early embryonic proliferation but dispensable for postnatal development and adult homeostasis. Ablation of FTase during tumor progression results in significant tumor reduction

658376

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Nicotiana tabacum

-

potential role for plant enzyme in cell cycle regulation

637519

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Pisum sativum

-

potential role for plant enzyme in cell cycle regulation

637519

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Plasmodium falciparum

-

potential role for cell cycle

637524

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Rattus norvegicus

-

-

637499, 637522, 637523, 637525

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Rattus norvegicus

-

process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics

637501, 637502, 637503, 637505

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Rattus norvegicus

-

process necessary for the subcellular localisation of substrate to the plasma membrane

637501, 637502, 637503, 637505, 637513, 637514, 637521

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Rattus norvegicus

-

enzyme responsible for catalysing isoprene lipid modifications

637501, 637502, 637505

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Rattus norvegicus

-

A series of steps modifies the C-terminus of Ras. Enzyme catalyses the first of these steps by transferring the farnesyl group from farnesyl diphosphates to the cysteine side chain in the CAAX sequence motif at the C-terminus of Ras

637502, 637521

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Rattus norvegicus

-

catalyzes the post-translational modification of many important cellular proteins

658096

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Saccharomyces cerevisiae

-

-

636537

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Saccharomyces cerevisiae

-

process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics

637505, 637507

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Saccharomyces cerevisiae

-

process necessary for the subcellular localisation of substrate to the plasma membrane

637505, 637507

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Solanum lycopersicum

-

a possible role for the enzyme during fruit development

637520

-

-

?

farnesyl diphosphate + protein-cysteine

S-farnesyl protein + diphosphate

Toxoplasma gondii

-

enzyme responsible for catalysing isoprene lipid modifications

637508

-

-

?

additional information

?

-

Rattus norvegicus

Q04631

ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo

737611

-

-

?

additional information

?

-

Saccharomyces cerevisiae

P29703

ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo

737611

-

-

?