2.5.1.58: protein farnesyltransferase

This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.

Word Map on EC 2.5.1.58

2.5.1.58

farnesylation

prenylation

geranylgeranylation

isoprenoids

beta-subunits

isoprenylation

15-carbon

lamins

manumycin

geranylgeranyltransferase-i

farnesyl-protein

h-ras

medicine

peptidomimetic

prelamin

ggtase-i

p21ras

tetrapeptide

farnesol

tetrahydroquinoline

ras-dependent

pharmacology

progerin

3hmevalonate

ras-induced

lovastatin

tipifarnib

drug development

ras-mediated

ras-transformed

lonafarnib

hutchinson-gilford

dimethylallyl

geranylgeraniol

isoprene

analysis

Reaction

Synonyms

AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.58 protein farnesyltransferase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
2	Activating Compound
3673	AA Sequence
44	Application
1	CAS Registry Number
37	Cloned(Commentary)
17	Crystallization (Commentary)
412	Disease/ Diagnostics
25	General Information
2	General Stability
420	IC50 Value
974	Inhibitors
240	kcat/KM [mM/s]
26	Ki Value [mM]
114	KM Value [mM]
4	Localization
78	Metals/Ions
36	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
5	Organic Solvent Stability
151	Organism
2	Pathway
114	PDB ID
20	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
59	Protein Variants
30	Purification (Commentary)
18	Reaction
145	Reference
39	Source Tissue
6	Specific Activity [micromol/min/mg]
486	Substrates and Products (Substrate)
30	Subunits
145	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
114	Turnover Number [1/s]

Source Tissue

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Source Tissue on EC 2.5.1.58 - protein farnesyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Source Tissue Search

Trypanosoma brucei brucei

protein farnesylation is essential for early embryonic proliferation

658376

epimastigote

Trypanosoma cruzi

Q8WR02, Q8WR03, Q8WR04

Crftb is expressed in ovules

660285

fruit

Solanum lycopersicum

decreased activity approximately 10fold between young and mature green fruits, increased activity during fruit development in red ripe fruit

Crftb

Crftb transcripts are localised next to the xylem in the external (abaxial) conducting phloem region. Crdxs is expressed in internal (adaxial) phloem parenchyma cells that are located above the internal (adaxial) conducting phloem on the opposite side of the xylem

high activity in tissues from young plants

Q8WR02, Q8WR03, Q8WR04

637511

additional information

3 entries