2.5.1.60: protein geranylgeranyltransferase type II

This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type II, go to the full flat file.

Word Map on EC 2.5.1.60

2.5.1.60

gtpases

endosomes

geranylgeranylation

prenylation

vesicular

escort

traffic

endocytic

cargo

rab11b

choroideremia

rab3a

gdp-bound

rab11-fip2

farnesyltransferase

prenyltransferase

ftase

hermansky-pudlak

rab11-positive

pericentrosomal

unprenylated

rabgdis

medicine

rab11-dependent

Reaction

Synonyms

AtRGTA1, AtRGTA2, AtRGTB1, Chm, geranylgeranyl transferase type I subunit alpha 1, geranylgeranyl transferase type I subunit alpha 2, geranylgeranyl transferase type II subunit beta 1, geranylgeranyl transferase type II subunit beta 2, geranylgeranyl transferase type-1 subunit alpha 1, geranylgeranyl transferase type-2 subunit alpha 2, geranylgeranyl transferase type-2 subunit beta 1, geranylgeranyl transferase type-2 subunit beta 2, geranylgeranyltransferase II, geranylgeranyltransferase type II, GGT2, GGTase-II, GGTase3, GGTaseII, PGGT-II, protein geranylgeranyltransferase type-II, PTAR1, Rab geranylgeranyl transferase, Rab geranylgeranyl transferase alpha subunit 2, Rab geranylgeranyl transferase beta subunit 1, Rab geranylgeranyl transferase beta subunit 2, Rab geranylgeranyl transferase lpha subunit 1, Rab geranylgeranyl-transferase, Rab geranylgeranyltransferase, Rab geranylgeranyltransferase type II, Rab GG transferase, Rab GGTase, Rab proteins geranylgeranyltransferase component A 1, RAB-GGT, Rab-GGT alpha 1, Rab-GGT alpha 2, Rab-GGT beta 1, Rab-GGT beta 2, Rab11a, RabGGT, RabGGTase, Rabggtb, REP/GGTase, RGGT, RGT alphabeta, RGTA1, RGTA2, RGTB1, RGTB2

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.60 protein geranylgeranyltransferase type II

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Results	in table
8	Activating Compound
6396	AA Sequence
3	Application
1	CAS Registry Number
18	Cloned(Commentary)
2	Cofactor
6	Crystallization (Commentary)
280	Disease/ Diagnostics
2	Expression
16	General Information
32	IC50 Value
89	Inhibitors
10	Ki Value [mM]
9	KM Value [mM]
2	Localization
5	Metals/Ions
6	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
55	Organism
43	PDB ID
2	pH Optimum
6	Protein Variants
11	Purification (Commentary)
19	Reaction
50	Reference
24	Source Tissue
4	Specific Activity [micromol/min/mg]
79	Substrates and Products (Substrate)
10	Subunits
100	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.5.1.60 - protein geranylgeranyltransferase type II

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Insulin

Mus musculus

promotes the phosphorylation of the alpha subunit of enzyme without an effect on beta subunit, and activation of enzyme, insulin increases the amount of geranylgeranylated Rab3 and Rab4 proteins

638598

Nonidet P-40

4 entries

Rab escort protein

2 entries

additional information

Arabidopsis thaliana

the enzyme is absolutely dependent on the Rab escort protein, REP, cloning and expression of His-tagged REP in Escherichia coli, and purification, overview, recombinant Arabidopsis thaliana REP-6His stimulates Rab geranylgeranylation activity in plant but not yeast cell extracts, overview

675344