2.5.1.60: protein geranylgeranyltransferase type II
This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type II, go to the full flat file.
Word Map on EC 2.5.1.60
-
2.5.1.60
-
gtpases
-
endosomes
-
geranylgeranylation
-
prenylation
-
vesicular
-
escort
-
traffic
-
endocytic
-
cargo
-
rab11b
-
choroideremia
-
rab3a
-
gdp-bound
-
rab11-fip2
-
farnesyltransferase
-
prenyltransferase
-
ftase
-
hermansky-pudlak
-
rab11-positive
-
pericentrosomal
-
unprenylated
-
rabgdis
-
medicine
-
rab11-dependent
- 2.5.1.60
- gtpases
- endosomes
-
geranylgeranylation
-
prenylation
- vesicular
-
escort
-
traffic
-
endocytic
-
cargo
-
rab11b
- choroideremia
- rab3a
-
gdp-bound
-
rab11-fip2
-
farnesyltransferase
- prenyltransferase
- ftase
-
hermansky-pudlak
-
rab11-positive
-
pericentrosomal
-
unprenylated
-
rabgdis
- medicine
-
rab11-dependent
Reaction
Synonyms
AtRGTA1, AtRGTA2, AtRGTB1, Chm, geranylgeranyl transferase type I subunit alpha 1, geranylgeranyl transferase type I subunit alpha 2, geranylgeranyl transferase type II subunit beta 1, geranylgeranyl transferase type II subunit beta 2, geranylgeranyl transferase type-1 subunit alpha 1, geranylgeranyl transferase type-2 subunit alpha 2, geranylgeranyl transferase type-2 subunit beta 1, geranylgeranyl transferase type-2 subunit beta 2, geranylgeranyltransferase II, geranylgeranyltransferase type II, GGT2, GGTase-II, GGTase3, GGTaseII, PGGT-II, protein geranylgeranyltransferase type-II, PTAR1, Rab geranylgeranyl transferase, Rab geranylgeranyl transferase alpha subunit 2, Rab geranylgeranyl transferase beta subunit 1, Rab geranylgeranyl transferase beta subunit 2, Rab geranylgeranyl transferase lpha subunit 1, Rab geranylgeranyl-transferase, Rab geranylgeranyltransferase, Rab geranylgeranyltransferase type II, Rab GG transferase, Rab GGTase, Rab proteins geranylgeranyltransferase component A 1, RAB-GGT, Rab-GGT alpha 1, Rab-GGT alpha 2, Rab-GGT beta 1, Rab-GGT beta 2, Rab11a, RabGGT, RabGGTase, Rabggtb, REP/GGTase, RGGT, RGT alphabeta, RGTA1, RGTA2, RGTB1, RGTB2
ECTree
2.5.1.60 protein geranylgeranyltransferase type IIAdvanced search results
results (
results (Reference
top
Reference on EC 2.5.1.60 - protein geranylgeranyltransferase type II
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Casey, P.J.; Seabra, M.C.
Protein prenyltransferases
J. Biol. Chem.
271
5289-5292
1996
Saccharomyces cerevisiae
Wilson, A.L.; Erdman, R.A.; Castellano, F.; Maltese, W.A.
Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases
Biochem. J.
333
497-504
1998
Bos taurus
-
Seabra, M.C.; Goldstein, J.L.; Sudhof, T.C.; Brown, M.S.
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys
J. Biol. Chem.
267
14497-14503
1992
Rattus norvegicus
Farnsworth, C.C.; Seabra, M.C.; Ericsson, L.H.; Gelb, M.H.; Glomset, J.A.
Rab geranylgeranyl transferase catalyses the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
Proc. Natl. Acad. Sci. USA
91
11963-11967
1994
Rattus norvegicus
Zhang, H.; Seabra, M.C.; Deisenhofer, J.
Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution
Structure Fold. Des.
8
241-251
2000
Rattus norvegicus
Thomä, N.H.; Iakovenko, A.; Owen, D.; Scheidig, A.S.; Waldmann, H.; Goody, R.S.; Alexandrov, K.
Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II
Biochemistry
39
12043-12052
2000
Rattus norvegicus
Thomä, N.H.; Niculae, A.; Goody, R.S.; Alexandrov, K.
Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate
J. Biol. Chem.
276
48631-48636
2001
Rattus norvegicus
Thomä, N.H.; Iakovenko, A.; Kalinin, A.; Waldmann, H.; Goody, R.S.; Alexandrov, K.
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II
Biochemistry
40
268-274
2001
Rattus norvegicus
Kalinin, A.; Thomä, N.H.; Iakovenko, A.; Heinemann, I.; Rostkova, E.; Constantinescu, A.T.; Alexandrov, K.
Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins
Protein Expr. Purif.
22
84-91
2001
Rattus norvegicus
Rak, A.; Niculae, A.; Kalinin, A.; Thomä, N.H.; Sidorovitch, V.; Goody, R.S.; Alexandrov, K.
In vitro assembly, purification, and crystallization of the Rab geranylgeranyl transferase:substrate complex
Protein Expr. Purif.
25
23-30
2002
Rattus norvegicus
Dursina, B.; Thomä, N.H.; Sidorovitch, V.; Niculae, A.; Iakovenko, A.; Rak, A.; Albert, S.; Ceacareanu, A.C.; Kolling, R.; Herrmann, C.; Goody, R.S.; Alexandrov, K.
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates
Biochemistry
41
6805-6816
2002
Saccharomyces cerevisiae, Rattus norvegicus
Pylypenko, O.; Rak, A.; Reents, R.; Niculae, A.; Sidorovitch, V.; Cioaca, M.D.; Bessolitsyna, E.; Thoma, N.H.; Waldmann, H.; Schlichting, I.; Goody, R.S.; Alexandrov, K.
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase
Mol. Cell
11
483-494
2003
Rattus norvegicus
Johannes, L.; Perez, F.; Laran-Chich, M.P.; Henry, J.P.; Darchen, F.
Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II
Eur. J. Biochem.
239
362-368
1996
Rattus norvegicus, Homo sapiens (P53611)
Goalstone, M.L.; Leitner, J.W.; Golovchenko, I.; Stjernholm, M.R.; Cormont, M.; Le Marchand-Brustel, Y.; Draznin, B.
Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4
J. Biol. Chem.
274
2880-2884
1999
Mus musculus
Loraine, A.E.; Yalovsky, S.; Fabry, S.; Gruissen, W.
Tomato Rab1A homologs as molecular tools for studying Rab geranylgeranyl transferase in plant cells
Plant Physiol.
110
1337-1347
1996
Saccharomyces cerevisiae, Solanum lycopersicum, Nicotiana tabacum
Witter, D.J.; Poulter, C.D.
Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme
Biochemistry
35
10454-10463
1996
Saccharomyces cerevisiae, Saccharomyces cerevisiae JRY1550
Coxon, F.P.; Ebetino, F.H.; Mules, E.H.; Seabra, M.C.; McKenna, C.E.; Rogers, M.J.
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo
Bone
37
349-358
2005
Mus musculus
Lackner, M.R.; Kindt, R.M.; Carroll, P.M.; Brown, K.; Cancilla, M.R.; Chen, C.; de Silva, H.; Franke, Y.; Guan, B.; Heuer, T.; Hung, T.; Keegan, K.; Lee, J.M.; Manne, V.; O'Brien, C.; Parry, D.; Perez-Villar, J.J.; Reddy, R.K.; Xiao, H.; Zhan, H.; Cockett, M.; Plowman, G.; Fitzgerald, K.; Costa, M.; Ross-Macdonald, P.
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors
Cancer Cell
7
325-336
2005
Caenorhabditis elegans, Homo sapiens
Maurer-Stroh, S.; Washietl, S.; Eisenhaber, F.
Protein prenyltransferases
Genome Biol.
4
212
2003
Homo sapiens
Wojtas, M.; Swiezewski, S.; Sarnowski, T.J.; Plochocka, D.; Chelstowska, A.; Tolmachova, T.; Swiezewska, E.
Cloning and characterization of Rab Escort Protein (REP) from Arabidopsis thaliana
Cell Biol. Int.
31
246-251
2007
Arabidopsis thaliana
Goody, R.S.; Rak, A.; Alexandrov, K.
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments
Cell. Mol. Life Sci.
62
1657-1670
2005
Saccharomyces cerevisiae
Wu, Y.; Waldmann, H.; Reents, R.; Ebetino, F.H.; Goody, R.S.; Alexandrov, K.
A protein fluorescence amplifier: continuous fluorometric assay for Rab geranylgeranyltransferase
Chembiochem
7
1859-1861
2006
Rattus norvegicus
Hala, M.; Elias, M.; Zarsky, V.
A specific feature of the angiosperm Rab escort protein (REP) and evolution of the REP/GDI superfamily
J. Mol. Biol.
348
1299-1313
2005
Arabidopsis thaliana
Baron, R.A.; Seabra, M.C.
Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate
Biochem. J.
415
67-75
2008
Homo sapiens
Claessens, A.; Weyn, C.; Merregaert, J.
The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase
Cell. Mol. Biol. Lett.
13
250-259
2008
Mus musculus
Guo, Z.; Wu, Y.W.; Das, D.; Delon, C.; Cramer, J.; Yu, S.; Thuns, S.; Lupilova, N.; Waldmann, H.; Brunsveld, L.; Goody, R.S.; Alexandrov, K.; Blankenfeldt, W.
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
EMBO J.
27
2444-2456
2008
Rattus norvegicus
Watanabe, M.; Fiji, H.D.; Guo, L.; Chan, L.; Kinderman, S.S.; Slamon, D.J.; Kwon, O.; Tamanoi, F.
Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds
J. Biol. Chem.
283
9571-9579
2008
Rattus norvegicus
Marma, M.S.; Xia, Z.; Stewart, C.; Coxon, F.; Dunford, J.E.; Baron, R.; Kashemirov, B.A.; Ebetino, F.H.; Triffitt, J.T.; Russell, R.G.; McKenna, C.E.
Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate
J. Med. Chem.
50
5967-5975
2007
Rattus norvegicus
Wu, Y.W.; Alexandrov, K.; Brunsveld, L.
Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase
Nat. Protoc.
2
2704-2711
2007
Rattus norvegicus
Wu, Y.W.; Goody, R.S.; Abagyan, R.; Alexandrov, K.
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation
J. Biol. Chem.
284
13185-13192
2009
Homo sapiens
Baron, R.A.; Tavare, R.; Figueiredo, A.C.; B?azewska, K.M.; Kashemirov, B.A.; McKenna, C.E.; Ebetino, F.H.; Taylor, A.; Rogers, M.J.; Coxon, F.P.; Seabra, M.C.
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase
J. Biol. Chem.
284
6861-6868
2009
Homo sapiens
Tan, K.T.; Guiu-Rozas, E.; Bon, R.S.; Guo, Z.; Delon, C.; Wetzel, S.; Arndt, S.; Alexandrov, K.; Waldmann, H.; Goody, R.S.; Wu, Y.W.; Blankenfeldt, W.
Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors
J. Med. Chem.
52
8025-8037
2009
Homo sapiens
Hala, M.; Soukupova, H.; Synek, L.; Zarsky, V.
Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects
Plant J.
62
615-627
2010
Arabidopsis thaliana
Zhou, X.; Hartman, S.V.; Born, E.J.; Smits, J.P.; Holstein, S.A.; Wiemer, D.F.
Triazole-based inhibitors of geranylgeranyltransferase II
Bioorg. Med. Chem. Lett.
23
764-766
2013
Homo sapiens
Coxon, F.P.; Taylor, A.; Stewart, C.A.; Baron, R.; Seabra, M.C.; Ebetino, F.H.; Rogers, M.J.
The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates
Bone
49
111-121
2011
Mus musculus
Arora, D.; Syed, I.; Machhadieh, B.; McKenna, C.; Kowluru, A.
Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic beta cells
Islets
4
354-358
2012
Rattus norvegicus
Shi, W.; Zeng, Q.; Kunkel, B.N.; Running, M.P.
Arabidopsis Rab geranylgeranyltransferases demonstrate redundancy and broad substrate specificity in vitro
J. Biol. Chem.
291
1398-1410
2016
Arabidopsis thaliana (Q84J75), Arabidopsis thaliana (Q8VYB7), Arabidopsis thaliana (Q9FJ32), Arabidopsis thaliana (Q9LHL5), Arabidopsis thaliana
Gutkowska, M.; Wnuk, M.; Nowakowska, J.; Lichocka, M.; Stronkowski, M.M.; Swiezewska, E.
Rab geranylgeranyl transferase beta subunit is essential for male fertility and tip growth in Arabidopsis
J. Exp. Bot.
66
213-224
2015
Arabidopsis thaliana (Q84J75), Arabidopsis thaliana (Q9LHL5), Arabidopsis thaliana Col-0 (Q84J75), Arabidopsis thaliana Col-0 (Q9LHL5)
Koehnke, M.; Delon, C.; Hastie, M.L.; Nguyen, U.T.; Wu, Y.W.; Waldmann, H.; Goody, R.S.; Gorman, J.J.; Alexandrov, K.
Rab GTPase prenylation hierarchy and its potential role in choroideremia disease
PLoS ONE
8
e81758
2013
Homo sapiens
Joachimiak, L.; Marchwicka, A.; Gendaszewska-Darmach, E.; Blazewska, K.M.
Synthesis and biological evaluation of imidazole-bearing alpha-phosphonocarboxylates as inhibitors of Rab geranylgeranyl transferase (RGGT)
ChemMedChem
13
842-851
2018
Homo sapiens (P24386)
Kazmierczak, A.; Kusy, D.; Niinivehmas, S.P.; Gmach, J.; Joachimiak, L.; Pentikaeinen, O.T.; Gendaszewska-Darmach, E.; Blazewska, K.M.
Identification of the privileged position in the imidazo[1,2-a]pyridine ring of phosphonocarboxylates for development of Rab geranylgeranyl transferase (RGGT) inhibitors
J. Med. Chem.
60
8781-8800
2017
Homo sapiens (P24386)
Kuchay, S.; Wang, H.; Marzio, A.; Jain, K.; Homer, H.; Fehrenbacher, N.; Philips, M.R.; Zheng, N.; Pagano, M.
GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase
Nat. Struct. Mol. Biol.
26
628-636
2019
Homo sapiens (P53611 and Q7Z6K3), Homo sapiens
Haney, S.L.; Varney, M.L.; Chhonker, Y.S.; Shin, S.; Mehla, K.; Crawford, A.J.; Smith, H.J.; Smith, L.M.; Murry, D.J.; Hollingsworth, M.A.; Holstein, S.A.
Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma
Oncogene
38
5308-5320
2019
Mus musculus
html completed
