2.5.1.61: hydroxymethylbilane synthase

This is an abbreviated version!
For detailed information about hydroxymethylbilane synthase, go to the full flat file.

Reaction

4 porphobilinogen +

Synonyms

(HMB)-synthase, AN0121.3, EC 4.3.1.8, HemC, hepatic porphobilinogen deaminase, HMB synthase, HMB-S, HMBS, HMBS1a-synthase, HMBS1b-synthase, HMBS2a-synthase, HMBS2b-synthase, human non-erythropoietic PBGD isoform, human PBGD, human porphobilinogen deaminase, hydroxymethylbilane synthase, More, PBG deaminase, PBG-D, PBG-deaminase, PBGD, PGB-D, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase, pre-uroporphyrinogen synthase, preuroporphyrinogen synthase, preuroporphyrinogen synthetase, synthase, uroporphyrinogen I, uPBGD, UPGI-S, URO-S, urogenI synthase, uroporphyrinogen I synthase, uroporphyrinogen I synthetase, uroporphyrinogen synthase, uroporphyrinogen synthetase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.61 hydroxymethylbilane synthase

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Results	in table
39084	AA Sequence
9	Application
2	CAS Registry Number
21	Cloned(Commentary)
11	Cofactor
8	Crystallization (Commentary)
2136	Disease/ Diagnostics
3	Expression
23	General Information
3	General Stability
94	Inhibitors
40	KM Value [mM]
10	Localization
45	Molecular Weight [Da]
104	Natural Substrates/ Products (Substrates)
272	Organism
1	Oxidation Stability
8	Pathway
32	PDB ID
28	pH Optimum
18	pH Range
1	pH Stability
92	Protein Variants
34	Purification (Commentary)
7	Reaction
1	Reaction Type
99	Reference
47	Source Tissue
43	Specific Activity [micromol/min/mg]
13	Storage Stability
256	Substrates and Products (Substrate)
34	Subunits
157	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Temperature Stability [°C]
1	Turnover Number [1/s]

Oxidation Stability

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Oxidation Stability on EC 2.5.1.61 - hydroxymethylbilane synthase

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OXIDATION STABILITY

ORGANISM

UNIPROT

LITERATURE

photooxidation of the enzyme in the presence of methylene blue, 0.03%, and roes bengal, 0.03%, over a 5 min period, inhibits 90% and 60% of the enzyme activity, respectively

Homo sapiens

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5883