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2.5.1.61: hydroxymethylbilane synthase

This is an abbreviated version!
For detailed information about hydroxymethylbilane synthase, go to the full flat file.

Word Map on EC 2.5.1.61

Reaction

4 porphobilinogen +

H2O
=
Hydroxymethylbilane
 + 4 NH3

Synonyms

(HMB)-synthase, AN0121.3, EC 4.3.1.8, HemC, hepatic porphobilinogen deaminase, HMB synthase, HMB-S, HMBS, HMBS1a-synthase, HMBS1b-synthase, HMBS2a-synthase, HMBS2b-synthase, human non-erythropoietic PBGD isoform, human PBGD, human porphobilinogen deaminase, hydroxymethylbilane synthase, More, PBG deaminase, PBG-D, PBG-deaminase, PBGD, PGB-D, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase, pre-uroporphyrinogen synthase, preuroporphyrinogen synthase, preuroporphyrinogen synthetase, synthase, uroporphyrinogen I, uPBGD, UPGI-S, URO-S, urogenI synthase, uroporphyrinogen I synthase, uroporphyrinogen I synthetase, uroporphyrinogen synthase, uroporphyrinogen synthetase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.61 hydroxymethylbilane synthase

Specific Activity

Specific Activity on EC 2.5.1.61 - hydroxymethylbilane synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000039
-
purified recombinant GST-tagged mutant enzyme
0.001
mutant enzyme D44A, at 37°C
0.00117
-
-
0.002
R167Q mutant, pH 8.0
0.0128
-
40 kDa enzyme form
0.0183
-
42 kDa enzyme form
0.022
-
purified recombinant GST-tagged wild-type enzyme
0.023
wild type, pH 8.0
0.038
-
A form
0.039
-
B form
0.04
-
-
0.0402
-
-
0.0813
-
-
0.113
-
at pH 7.4
0.333
-
200 nM porphobilinogen, 50 mM Tris-HCl, pH 8.0, 25°C
additional information