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2.5.1.68: (2Z,6E)-farnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about (2Z,6E)-farnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.68

Reaction

geranyl diphosphate
+
isopentenyl diphosphate
=
diphosphate
 +
(2Z,6E)-farnesyl diphosphate

Synonyms

cis-farnesyl diphosphate synthase, cis-FPS, Mvan 4662, omega,E,Z-FPP, Rv1086, short (C15) chain Z-isoprenyl diphosphate synthase, Z,E-FPP synthase, Z-farnesyl diphosphate synthase, Z-FPP synthase, ZPT1

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.68 (2Z,6E)-farnesyl diphosphate synthase

Inhibitors

Inhibitors on EC 2.5.1.68 - (2Z,6E)-farnesyl diphosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1-[[(3E)-4,8-dimethylnona-3,7-dien-1-yl](hydroxy)phosphoryl]-1-ethylpropyl)phosphonic acid
-
-
(E)-1-ethyl-1-[(4,8-dimethyl-3,7-nonadienyl)hydroxyphosphoryl] propyl phosphonic acid tripotassium salt
-
-
(E)-geranyl diphosphate analogues
-
design and synthesis of substrate analogue inhibitors, overview
-
citronellyl diphosphate
-
-
EDTA
-
complete inhibition at 10 mM
Mn2+
-
optimal at 0.1 mM, the enzyme absolutely requires a divalent cation, inhibition by Mn2+ at higher concentration of 5.0 mM
additional information
-
no inhibition by dipotassium salt of (E)-1-[(3,7-methyl-2,6-octadienyl)aminocarbonyl] propyl phosphonic acid, dipotassium salt of (E)-1-[[(3,7-methyl-2,6-octadienyl)oxy]aminocarbonyl] propyl phosphonic acid, and dipotassium salt of (E)-2-oxo-2-[(3,7-methyl-2,6-octadienyl)oxy-[amino]ethyl]phosphonic acid
-