2.5.1.7: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
This is an abbreviated version!
For detailed information about UDP-N-acetylglucosamine 1-carboxyvinyltransferase, go to the full flat file.
Word Map on EC 2.5.1.7
-
2.5.1.7
-
peptidoglycan
-
fosfomycin
-
pep
-
cloacae
-
enterobacter
-
medicine
-
epsps
-
drug development
-
5-enolpyruvylshikimate
-
sanguinis
-
5-enolpyruvylshikimate-3-phosphate
- 2.5.1.7
- peptidoglycan
- fosfomycin
- pep
- cloacae
- enterobacter
- medicine
- epsps
- drug development
-
5-enolpyruvylshikimate
- sanguinis
- 5-enolpyruvylshikimate-3-phosphate
Reaction
Synonyms
enol-pyruvyltransferase, enolpyruvyl UDP-GlcNAc synthase, enoylpyruvate transferase, enoylpyruvatetransferase, EPT, More, MurA, MurA enzyme, MurA transferase, MurAA, MurZ, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose-3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvatetransferase, phosphoenolpyruvate-uridine diphosphoacetylglucosamine, pyruvic-uridine diphospho-N-acetylglucosaminyltransferase, UDP-GlcNAc enolpyruvyl transferase, UDP-N-acetylglucosamine 1-carboxyvinyl transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, UDP-N-acetylglucosamine enolpyruvyl transferase, UDP-N-acetylglucosamine enolpyruvyle transferase, UDP-N-acetylglucosamine enolpyruvyltransferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, UDP-N-acetylglucosamine-enolpyruvyl transferase, UDP-NAG enolpyruvyl transferase, UNAG enolpyruvyl transferase
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Reference on EC 2.5.1.7 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gunetileke, K.G.; Anwar, R.A.
Biosynthesis of uridine diphospho-N-acetylmuramic acid. II. Purification and properties of pyruvate-uridine diphospho-N-acetylglucosamine transferase and characterization of uridine diphospho-N-acetylenopyruvylglucosamine
J. Biol. Chem.
243
5770-5778
1968
Enterobacter cloacae, Enterobacter cloacae NRC 492
Zemell, R.I.; Anwar, R.A.
Pyruvate-uridine diphospho-N-acetylglucosamine transferase. Purification to homogeneity and feedback inhibition
J. Biol. Chem.
250
3185-3192
1975
Enterobacter cloacae
Zemell, R.I.; Anwar, R.A.
Mechanism of pyruvate-uridine diphospho-N-acetylglucosamine transferase. Evidence for an enzyme-enolpyruvate intermediate
J. Biol. Chem.
250
4959-4964
1975
Enterobacter cloacae
Venkateswaran, P.S.; Lugtenberg, E.J.J.; Wu, H.C.
Inhibition of phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase by uridine diphosphate N-acetylmuramyl peptides
Biochim. Biophys. Acta
293
570-574
1973
Bacillus cereus, Escherichia coli, Escherichia coli K-235, Bacillus cereus T
Wickus, G.G.; Strominger, J.L.
Partial purification and properties of the pyruvate-uridine diphospho-N-acetylglucosamine transferase from Staphylococcus epidermidis
J. Bacteriol.
113
287-290
1973
Staphylococcus epidermidis, Staphylococcus epidermidis Texas 26
Wanke, C.; Falchetto, R.; Amrhein, N.
The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae. Molecular cloning, sequencing of the gene and overexpression of the enzyme
FEBS Lett.
301
271-276
1992
Enterobacter cloacae, Enterobacter cloacae DSM 30054
Marquardt, J.L.; Siegele, D.A.; Kolter, R.; Walsh, C.T.
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase
J. Bacteriol.
174
5748-5752
1992
Escherichia coli (P0A749), Escherichia coli
Anwar, R.A.; Vlaovic, M.
Effect of phosphoenolpyruvate analogs on the activity of enoylpyruvate transferase and the effect of UDP-N-acetylglucosamine on the reactivity of the active site SH group
Biochim. Biophys. Acta
616
389-394
1980
Enterobacter cloacae
Brown, E.D.; Vivas, E.I.; Walsh, C.T.; Kolter, R.
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli
J. Bacteriol.
177
4194-4197
1995
Escherichia coli (P0A749), Escherichia coli
Kim, D.H.; Lees, W.J.; Walsh, C.T.
Stereochemical analysis of the tetrahedral adduct formed at the active site of UDP-GlcNAc enolpyruvyl transferase from the pseudosubstrates, (E)- and (Z)-3-fluorophosphoenolpyruvate, in D2O
J. Am. Chem. Soc.
117
6380-6381
1995
Escherichia coli, Escherichia coli MurZ
-
Kim, D.H.; Lees, W.J.; Haley, T.M.; Walsh, C.T.
Kinetic characterization of the inactivation of UDP-GlcNAc enolpyruvyl transferase by (Z)-3-fluorophosphoenolpyruvate: evidence for two oxocarbenium ion intermediates in enolpyruvyl transfer catalysis
J. Am. Chem. Soc.
117
1494-1502
1995
Escherichia coli, Escherichia coli MurZ
-
Kim, D.H.; Lees, W.J.; Kempsell, K.E.; Lane, W.S.; Duncan, K.; Walsh, C.T.
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin
Biochemistry
35
4923-4928
1996
Enterobacter cloacae, Escherichia coli, Escherichia coli MurA
Skarzynski, T.; Mistry, A.; Wonacott, A.; Hutchinson, S.E.; Kelly, V.A.; Duncan, K.
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, and enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin
Structure
4
1465-1474
1996
Escherichia coli
Schoenbrunn, E.; Sack, S.; Eschenburg, S.; Perrakis, A.; Krekel, F.; Amrhein, N.; Mandelkow, E.
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin
Structure
4
1065-1075
1996
Enterobacter cloacae
Schonbrunn, E.; Svergun, D.I.; Amrhein, N.; Koch, M.H.J.
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA)
Eur. J. Biochem.
253
406-412
1998
Enterobacter cloacae, Enterobacter cloacae DSM 30054
Krekel, F.; Oecking, C.; Amrhein, N.; Macheroux, P.
Substrate and inhibitor-induced conformational changes in the structurally related enzymes UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS)
Biochemistry
38
8864-8878
1999
Enterobacter cloacae (P33038), Enterobacter cloacae DSM 30054 (P33038)
Samland, A.K.; Amrhein, N.; Macheroux, P.
Lysine 22 in UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae is crucial for enzymatic activity and the formation of covalent adducts with the substrate phosphoenolpyruvate and the antibiotic fosfomycin
Biochemistry
38
13162-13169
1999
Enterobacter cloacae (P33038), Enterobacter cloacae, Enterobacter cloacae DSM 30054 (P33038)
Du, W.; Brown, J.R.; Sylvester, D.R.; Huang, J.; Chalker, A.F.; So, C.Y.; Holmes, D.J.; Payne, D.J.; Wallis, N.G.
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria
J. Bacteriol.
182
4146-4152
2000
Streptococcus pneumoniae
Krekel, F.; Samland, A.K.; Macheroux, P.; Amrhein, N.; Evans, J.N.S.
Determination of the pKa value of C115 in MurA (UDP-N-acetylglucosamine enolpyruvyltransferase) from Enterobacter cloacae
Biochemistry
39
12671-12677
2000
Enterobacter cloacae, Enterobacter cloacae DSM 30054
Dai, H.J.; Parker, C.N.; Bao, J.J.
Characterization and inhibition study of MurA enzyme by capillary electrophoresis
J. Chromatogr. B
766
123-132
2002
Escherichia coli, Escherichia coli MurA
Samland, A.K.; Jelesarov, I.; Kuhn, R.; Amrhein, N.; Macheroux, P.
Thermodynamic characterization of ligand-induced conformational changes in UDP-N-acetylglucosamine enolpyruvyl transferase
Biochemistry
40
9950-9956
2001
Enterobacter cloacae (P33038), Enterobacter cloacae DSM 30054 (P33038)
Samland, A.K.; Etezady-Esfarjani, T.; Amrhein, N.; Macheroux, P.
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae
Biochemistry
40
1550-1559
2001
Enterobacter cloacae, Enterobacter cloacae DSM 30054
McCoy, A.J.; Sandlin, R.C.; Maurelli, A.T.
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance
J. Bacteriol.
185
1218-1228
2003
Chlamydia trachomatis, Chlamydia trachomatis MurA
Mizyed, S.; Oddone, A.; Byczynski, B.; Hughes, D.W.; Berti, P.J.
UDP-N-acetylmuramic acid (UDP-MurNAc) is a potent inhibitor of MurA (enolpyruvyl-UDP-GlcNAc synthase)
Biochemistry
44
4011-4017
2005
Escherichia coli
Thomas, A.M.; Ginj, C.; Jelesarov, I.; Amrhein, N.; Macheroux, P.
Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enolpyruvyl transferase
Eur. J. Biochem.
271
2682-2690
2004
Enterobacter cloacae (P33038)
Byczynski, B.; Mizyed, S.; Berti, P.J.
Nonenzymatic breakdown of the tetrahedral (alpha-carboxyketal phosphate) intermediates of MurA and AroA, two carboxyvinyl transferases. Protonation of different functional groups controls the rate and fate of breakdown
J. Am. Chem. Soc.
125
12541-12550
2003
Escherichia coli
Eschenburg, S.; Kabsch, W.; Healy, M.L.; Schonbrunn, E.
A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states
J. Biol. Chem.
278
49215-49222
2003
Enterobacter cloacae
Eschenburg, S.; Priestman, M.A.; Abdul-Latif, F.A.; Delachaume, C.; Fassy, F.; Schonbrunn, E.
A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA)
J. Biol. Chem.
280
14070-14075
2005
Enterobacter cloacae (P33038)
Zhang, F.; Berti, P.J.
Phosphate analogues as probes of the catalytic mechanisms of MurA and AroA, two carboxyvinyl transferases
Biochemistry
45
6027-6037
2006
Escherichia coli
Eschenburg, S.; Priestman, M.; Schoenbrunn, E.
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release
J. Biol. Chem.
280
3757-3763
2005
Enterobacter cloacae (P33038), Enterobacter cloacae
Klein, C.D.; Bachelier, A.
Molecular modeling and bioinformatical analysis of the antibacterial target enzyme MurA from a drug design perspective
J. Comput. Aided Mol. Des.
20
621-628
2006
Enterobacter cloacae, Escherichia coli
Griffiths, E.; Gupta, R.S.
Lateral transfers of serine hydroxymethyltransferase (glyA) and UDP-N-acetylglucosamine enolpyruvyl transferase (murA) genes from free-living Actinobacteria to the parasitic chlamydiae
J. Mol. Evol.
63
283-296
2006
Simkania negevensis (Q49K92), Simkania negevensis, Waddlia chondrophila (Q8GNY2), Waddlia chondrophila
Yoon, H.J.; Ku, M.J.; Ahn, H.J.; Lee, B.I.; Mikami, B.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic analysis of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin
Mol. Cell
19
398-401
2005
Haemophilus influenzae
Molina-Lopez, J.; Sanschagrin, F.; Levesque, R.C.
A peptide inhibitor of MurA UDP-N-acetylglucosamine enolpyruvyl transferase: the first committed step in peptidoglycan biosynthesis
Peptides
27
3115-3121
2006
Pseudomonas aeruginosa
Kedar, G.C.; Brown-Driver, V.; Reyes, D.R.; Hilgers, M.T.; Stidham, M.A.; Shaw, K.J.; Finn, J.; Haselbeck, R.J.
Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis
Antimicrob. Agents Chemother.
52
2009-2013
2008
Bacillus anthracis
Dunsmore, C.J.; Miller, K.; Blake, K.L.; Patching, S.G.; Henderson, P.J.; Garnett, J.A.; Stubbings, W.J.; Phillips, S.E.; Palestrant, D.J.; Angeles, J.D.; Leeds, J.A.; Chopra, I.; Fishwick, C.W.
2-Aminotetralones: novel inhibitors of MurA and MurZ
Bioorg. Med. Chem. Lett.
18
1730-1734
2008
Staphylococcus aureus, Escherichia coli (P0A749)
Steinbach, A.; Scheidig, A.J.; Klein, C.D.
The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography
J. Med. Chem.
51
5143-5147
2008
Escherichia coli (P0A749)
Yoon, H.; Lee, S.J.; Mikami, B.; Park, H.; Yoo, J.; Suh, S.W.
Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin
Proteins Struct. Funct. Bioinform.
71
1032-1037
2008
Haemophilus influenzae (P45025), Haemophilus influenzae
Kumar, S.; Parvathi, A.; Hernandez, R.L.; Cadle, K.M.; Varela, M.F.
Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli
Arch. Microbiol.
191
425-429
2009
Aliivibrio fischeri (B6DVJ7), Aliivibrio fischeri
Jackson, S.G.; Zhang, F.; Chindemi, P.; Junop, M.S.; Berti, P.J.
Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions
Biochemistry
48
11715-11723
2009
Escherichia coli (P0A749)
Jin, B.S.; Han, S.G.; Lee, W.K.; Ryoo, S.W.; Lee, S.J.; Suh, S.W.; Yu, Y.G.
Inhibitory mechanism of novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae
J. Microbiol. Biotechnol.
19
1582-1589
2009
Haemophilus influenzae (P45025), Haemophilus influenzae
Blake, K.L.; ONeill, A.J.; Mengin-Lecreulx, D.; Henderson, P.J.; Bostock, J.M.; Dunsmore, C.J.; Simmons, K.J.; Fishwick, C.W.; Leeds, J.A.; Chopra, I.
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors
Mol. Microbiol.
72
335-343
2009
Staphylococcus aureus
Dube, S.; Nanda, K.; Rani, R.; Kaur, N.; Nagpal, J.; Upadhyay, D.; Cliffe, I.; Saini, K.; Purnapatre, K.
UDP-N-acetylglucosamine enolpyruvyl transferase from Pseudomonas aeruginosa
World J. Microbiol. Biotechnol.
26
1623-1629
2010
Escherichia coli, Pseudomonas aeruginosa
Bensen, D.C.; Rodriguez, S.; Nix, J.; Cunningham, M.L.; Tari, L.W.
Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) from Vibrio fischeri in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin
Acta Crystallogr. Sect. F
68
382-385
2012
Aliivibrio fischeri (B5F9P4), Aliivibrio fischeri, Aliivibrio fischeri MJ11 (B5F9P4)
Vesic, D.; Kristich, C.J.
MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis
Antimicrob. Agents Chemother.
56
2443-2451
2012
Enterococcus faecalis
Gautam, A.; Rishi, P.; Tewari, R.
UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments
Appl. Microbiol. Biotechnol.
92
211-225
2011
Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli (P0A749), Enterobacter cloacae (P33038), Mycobacterium tuberculosis (P9WJM1), Mycobacterium tuberculosis H37Rv (P9WJM1)
Cheng, G.; Hu, Y.; Lu, N.; Li, J.; Wang, Z.; Chen, Q.; Zhu, B.
Identification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome
Biotechnol. Lett.
35
273-278
2013
uncultured bacterium (H2DMJ3)
Han, S.; Jin, B.; Lee, W.; Yu, Y.
Kinetic properties of wild-type and C117D mutant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Haemophilus influenzae
Bull. Korean Chem. Soc.
32
2549-2552
2011
Haemophilus influenzae
-
Babajan, B.; Chaitanya, M.; Rajsekhar, C.; Gowsia, D.; Madhusudhana, P.; Naveen, M.; Chitta, S.K.; Anuradha, C.M.
Comprehensive structural and functional characterization of Mycobacterium tuberculosis UDP-NAG enolpyruvyl transferase (Mtb-MurA) and prediction of its accurate binding affinities with inhibitors
Interdiscip. Sci.
3
204-216
2011
Mycobacterium tuberculosis (P9WJM1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WJM1)
Miller, K.; Dunsmore, C.J.; Leeds, J.A.; Patching, S.G.; Sachdeva, M.; Blake, K.L.; Stubbings, W.J.; Simmons, K.J.; Henderson, P.J.; De Los Angeles, J.; Fishwick, C.W.; Chopra, I.
Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ)
J. Antimicrob. Chemother.
65
2566-2573
2010
Escherichia coli, Staphylococcus aureus, Escherichia coli JM109, Staphylococcus aureus SH1000
Zhu, J.Y.; Yang, Y.; Han, H.; Betzi, S.; Olesen, S.H.; Marsilio, F.; Schoenbrunn, E.
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)
J. Biol. Chem.
287
12657-12667
2012
Enterobacter cloacae (P33038)
Kaur, N.; Khokhar, M.; Jain, V.; Bharatam, P.V.; Sandhir, R.; Tewari, R.
Identification of druggable targets for Acinetobacter baumannii via subtractive genomics and plausible inhibitors for MurA and MurB
Appl. Biochem. Biotechnol.
171
417-436
2013
Acinetobacter baumannii
Hrast, M.; Sosic, I.; Sink, R.; Gobec, S.
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F
Bioorg. Chem.
55
2-15
2014
Escherichia coli
Shigetomi, K.; Olesen, S.H.; Yang, Y.; Mitsuhashi, S.; Schoenbrunn, E.; Ubukata, M.
MurA as a primary target of tulipalin B and 6-tuliposide B
Biosci. Biotechnol. Biochem.
77
2517-2519
2013
Enterobacter cloacae, Escherichia coli
Han, S.G.; Lee, W.K.; Jin, B.S.; Lee, K.I.; Lee, H.H.; Yu, Y.G.
Identification of novel irreversible inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Haemophilus influenzae
J. Microbiol. Biotechnol.
23
329-334
2013
Haemophilus influenzae
Shahab, M.; Verma, M.; Pathak, M.; Mitra, K.; Misra-Bhattacharya, S.
Cloning, expression and characterization of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Wolbachia endosymbiont of human lymphatic filarial parasite Brugia malayi
PLoS ONE
9
e99884
2014
Wolbachia sp.
Xu, L.; Wu, D.; Liu, L.; Zheng, Q.; Song, Y.; Ye, L.; Sha, S.; Kang, J.; Xin, Y.; Ma, Y.
Characterization of mycobacterial UDP-N-acetylglucosamine enolpyruvyle transferase (MurA)
Res. Microbiol.
165
91-101
2014
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
Lima, A.H.; Dos Santos, A.M.; Alves, C.N.; Lameira, J.
Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa
Chem. Biol. Drug Des.
89
599-607
2017
Pseudomonas aeruginosa
Boulhissa, I.; Chikhi, A.; Bensegueni, A.; Ghattas, M.A.; Mokrani, E.H.; Alrawashdeh, S.; Eddin Obaid, D.E.
Investigation for new inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) by virtual screening with antibacterial sssessment
Curr. Comput. Aided Drug Des.
17
214-224
2020
Escherichia coli (P0A749), Escherichia coli, Escherichia coli K12 (P0A749)
Alhaji Isa, M.; Majumdar, R.; Haider, S.; Kandasamy, S.
Molecular modelling and dynamic simulation of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) from Mycobacterium tuberculosis using in silico approach
Inform. Med. Unlocked
12
56-66
2018
Mycobacterium tuberculosis (P9WJM1), Mycobacterium tuberculosis ATCC 25618 (P9WJM1)
-
Sonkar, A.; Shukla, H.; Shukla, R.; Kalita, J.; Tripathi, T.
Unfolding of Acinetobacter baumannii MurA proceeds through a metastable intermediate A combined spectroscopic and computational investigation
Int. J. Biol. Macromol.
126
941-951
2019
Acinetobacter baumannii
Sonkar, A.; Shukla, H.; Shukla, R.; Kalita, J.; Pandey, T.; Tripathi, T.
UDP-N-Acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA) Structural and functional properties
Int. J. Biol. Macromol.
97
106-114
2017
Acinetobacter baumannii
Mihalovits, L.M.; Ferenczy, G.G.; Keseru, G.M.
Catalytic mechanism and covalent inhibition of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) Implications to the design of novel antibacterials
J. Chem. Inf. Model.
59
5161-5173
2019
Escherichia coli (P0A749)
Kumar, A.; Saranathan, R.; Prashanth, K.; Tiwary, B.K.; Krishna, R.
Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches
Mol. Biosyst.
13
939-954
2017
Fusobacterium nucleatum subsp. nucleatum (Q8RIQ1), Fusobacterium nucleatum subsp. nucleatum ATCC 25586 (Q8RIQ1)
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