2.5.1.72: quinolinate synthase

This is an abbreviated version!
For detailed information about quinolinate synthase, go to the full flat file.

Word Map on EC 2.5.1.72

2.5.1.72

nada

nicotinamide

dihydroxyacetone

iminoaspartate

iron-sulfur

pyrococcus

dhap

horikoshii

qa

cluster-containing

oxygen-sensitive

desulfurase

drug development

synthesis

Reaction

+ 2 H2O +

Synonyms

Fe4S4 quinolinate synthase, NadA, Old5, PfQS, quinolinate synthetase, SufE3, TM_1644

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.72 quinolinate synthase

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Results	in table
32559	AA Sequence
3	Application
1	CAS Registry Number
10	Cloned(Commentary)
13	Cofactor
5	Crystallization (Commentary)
6	General Information
4	IC50 Value
15	Inhibitors
1	KM Value [mM]
2	Localization
16	Metals/Ions
10	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
32	Organism
9	Pathway
32	PDB ID
2	pH Optimum
1	Posttranslational Modification
45	Protein Variants
8	Purification (Commentary)
6	Reaction
30	Reference
1	Renatured (Commentary)
5	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
6	Subunits
24	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.5.1.72 - quinolinate synthase

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1,10-phenanthroline

Escherichia coli

inhibits reactivation of O2-inactivated enzyme

684659

2,2'-dipyridyl

Escherichia coli

inhibits reactivation of O2-inactivated enzyme

684659

4,5-dithiohydroxyphthalic acid

Escherichia coli

structural analogue of the 5-hydroxy-4,5-dihydropyridine-2,3-dicarboxylic acid intermediate. Compound coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site, thus leading to the inhibition of quinolate formation. Compound is inhibitory in vitro and in vivo

721290

4-mercaptophthalic acid

2 entries

5-mercaptopyrazine-2,3-dicarboxylic acid

2 entries

6-mercaptopyridine-2,3-dicarboxylic acid

H2O2

1 mM, inactivation

paraquat

inactivation

Phosphoglycolic acid