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2.5.1.72: quinolinate synthase

This is an abbreviated version!
For detailed information about quinolinate synthase, go to the full flat file.

Word Map on EC 2.5.1.72

Reaction

glycerone phosphate
+
iminosuccinate
=
pyridine-2,3-dicarboxylate
+ 2 H2O +
phosphate

Synonyms

Fe4S4 quinolinate synthase, NadA, Old5, PfQS, quinolinate synthetase, SufE3, TM_1644

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.72 quinolinate synthase

Reference

Reference on EC 2.5.1.72 - quinolinate synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Katoh, A.; Uenohara, K.; Akita, M.; Hashimoto, T.
Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid
Plant Physiol.
141
851-857
2006
Arabidopsis thaliana
Manually annotated by BRENDA team
Gardner, P.R.; Fridovich, I.
Quinolinate synthetase: the oxygen-sensitive site of de novo NAD(P)+ biosynthesis
Arch. Biochem. Biophys.
284
106-111
1991
Escherichia coli
Manually annotated by BRENDA team
Saunders, A.H.; Griffiths, A.E.; Lee, K.H.; Cicchillo, R.M.; Tu, L.; Stromberg, J.A.; Krebs, C.; Booker, S.J.
Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes
Biochemistry
47
10999-11012
2008
Escherichia coli, Mycobacterium tuberculosis, Pyrococcus horikoshii
Manually annotated by BRENDA team
Saunders, A.H.; Booker, S.J.
Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation
Biochemistry
47
8467-8469
2008
Escherichia coli
Manually annotated by BRENDA team
Marinoni, I.; Nonnis, S.; Monteferrante, C.; Heathcote, P.; Haertig, E.; Boettger, L.H.; Trautwein, A.X.; Negri, A.; Albertini, A.M.; Tedeschi, G.
Characterization of L-aspartate oxidase and quinolinate synthase from Bacillus subtilis
FEBS J.
275
5090-5107
2008
Bacillus subtilis
Manually annotated by BRENDA team
Ollagnier-de Choudens, S.; Loiseau, L.; Sanakis, Y.; Barras, F.; Fontecave, M.
Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis
FEBS Lett.
579
3737-3743
2005
Escherichia coli
Manually annotated by BRENDA team
Rousset, C.; Fontecave, M.; Ollagnier de Choudens, S.
The [4Fe-4S] cluster of quinolinate synthase from Escherichia coli: investigation of cluster ligands
FEBS Lett.
582
2937-2944
2008
Escherichia coli
Manually annotated by BRENDA team
Cicchillo, R.M.; Tu, L.; Stromberg, J.A.; Hoffart, L.M.; Krebs, C.; Booker, S.J.
Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster
J. Am. Chem. Soc.
127
7310-7311
2005
Escherichia coli
Manually annotated by BRENDA team
Sakuraba, H.; Tsuge, H.; Yoneda, K.; Katunuma, N.; Ohshima, T.
Crystal structure of the NAD biosynthetic enzyme quinolinate synthase
J. Biol. Chem.
280
26645-26648
2005
Pyrococcus horikoshii (O57767), Pyrococcus horikoshii
Manually annotated by BRENDA team
Narayana Murthy, U.M.; Ollagnier-de-Choudens, S.; Sanakis, Y.; Abdel-Ghany, S.E.; Rousset, C.; Ye, H.; Fontecave, M.; Pilon-Smits, E.A.; Pilon, M.
Characterization of Arabidopsis thaliana SufE2 and SufE3: functions in chloroplast iron-sulfur cluster assembly and Nad synthesis
J. Biol. Chem.
282
18254-18264
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Schippers, J.H.; Nunes-Nesi, A.; Apetrei, R.; Hille, J.; Fernie, A.R.; Dijkwel, P.P.
The Arabidopsis onset of leaf death5 mutation of quinolinate synthase affects nicotinamide adenine dinucleotide biosynthesis and causes early ageing
Plant Cell
20
2909-2925
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Michalowski, C.B.; Flachmann, R.; Loeffelhardt, W.; Bohnert, H.J.
Gene nadA, encoding quinolinate synthetase, is located on the cyanelle DNA from Cyanophora paradoxa
Plant Physiol.
95
329-330
1991
Cyanophora paradoxa (P31179), Cyanophora paradoxa
Manually annotated by BRENDA team
Ceciliani, F.; Caramori, T.; Ronchi, S.; Tedeschi, G.; Mortarino, M.; Galizzi, A.
Cloning, overexpression, and purification of Escherichia coli quinolinate synthetase
Protein Expr. Purif.
18
64-70
2000
Escherichia coli
Manually annotated by BRENDA team
Chan, A.; Clemancey, M.; Mouesca, J.M.; Amara, P.; Hamelin, O.; Latour, J.M.; Ollagnier de Choudens, S.
Studies of inhibitor binding to the [4Fe-4S] cluster of quinolinate synthase
Angew. Chem. Int. Ed. Engl.
51
7711-7714
2012
Escherichia coli
Manually annotated by BRENDA team
Soriano, E.V.; Zhang, Y.; Colabroy, K.L.; Sanders, J.M.; Settembre, E.C.; Dorrestein, P.C.; Begley, T.P.; Ealick, S.E.
Active-site models for complexes of quinolinate synthase with substrates and intermediates
Acta Crystallogr. Sect. D
69
1685-1696
2013
Pyrococcus furiosus (Q8TZL3), Pyrococcus furiosus
Manually annotated by BRENDA team
Reichmann, D.; Coute, Y.; Ollagnier de Choudens, S.
Dual activity of quinolinate synthase: triose phosphate isomerase and dehydration activities play together to form quinolinate
Biochemistry
54
6443-6446
2015
Escherichia coli K-12 (P11458), Thermotoga maritima (Q9X1X7)
Manually annotated by BRENDA team
Cherrier, M.V.; Chan, A.; Darnault, C.; Reichmann, D.; Amara, P.; Ollagnier de Choudens, S.; Fontecilla-Camps, J.C.
The crystal structure of Fe4S4 quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad
J. Am. Chem. Soc.
136
5253-5256
2014
Thermotoga maritima (Q9X1X7), Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9X1X7)
Manually annotated by BRENDA team
Esakova, O.A.; Silakov, A.; Grove, T.L.; Saunders, A.H.; McLaughlin, M.I.; Yennawar, N.H.; Booker, S.J.
Structure of quinolinate synthase from Pyrococcus horikoshii in the presence of its product, quinolinic acid
J. Am. Chem. Soc.
138
7224-7227
2016
Pyrococcus horikoshii
Manually annotated by BRENDA team
Fenwick, M.K.; Ealick, S.E.
Crystal structures of the iron-sulfur cluster-dependent quinolinate synthase in complex with dihydroxyacetone phosphate, iminoaspartate analogues, and quinolinate
Biochemistry
55
4135-4139
2016
Pyrococcus horikoshii (O57767), Pyrococcus horikoshii, Pyrococcus horikoshii DSM 12428 (O57767)
Manually annotated by BRENDA team
Saez Cabodevilla, J.; Volbeda, A.; Hamelin, O.; Latour, J.M.; Gigarel, O.; Clemancey, M.; Darnault, C.; Reichmann, D.; Amara, P.; Fontecilla-Camps, J.C.; Ollagnier de Choudens, S.
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination
Chem. Commun. (Camb.)
55
3725-3728
2019
Escherichia coli (P11458), Thermotoga maritima (Q9X1X7), Thermotoga maritima DSM 3109 (Q9X1X7), Escherichia coli K12 (P11458)
Manually annotated by BRENDA team
Volbeda, A.; Darnault, C.; Renoux, O.; Reichmann, D.; Amara, P.; Ollagnier de Choudens, S.; Fontecilla-Camps, J.C.
Crystal Structures of quinolinate synthase in complex with a substrate analogue, the condensation intermediate, and substrate-derived product
J. Am. Chem. Soc.
138
11802-11809
2016
Thermotoga maritima (Q9X1X7), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X1X7)
Manually annotated by BRENDA team